Revealing curcumin therapeutic targets on SRC, PPARG, MAPK8 and HSP90 as liver cirrhosis therapy based on comprehensive bioinformatic study

• Published in: Journal of biomolecular structure & dynamics Vol. 43; no. 6; pp. 3172 - 3189
• Main Authors: Siregar, Khalish Arsy Al Khairy, Syaifie, Putri Hawa, Jauhar, Muhammad Miftah, Arda, Adzani Gaisani, Rochman, Nurul Taufiqu, Kustiawan, Paula Mariana, Mardliyati, Etik
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 13.04.2025
• Subjects: Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - genetics; Computational Biology - methods; curcumin; Curcumin - chemistry; Curcumin - pharmacology; Curcumin - therapeutic use; HSP90 Heat-Shock Proteins - antagonists & inhibitors; HSP90 Heat-Shock Proteins - chemistry; HSP90 Heat-Shock Proteins - genetics; HSP90 Heat-Shock Proteins - metabolism; Humans; Liver cirrhosis; Liver Cirrhosis - drug therapy; Liver Cirrhosis - genetics; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; Liver Neoplasms - drug therapy; Liver Neoplasms - genetics; molecular docking; Molecular Docking Simulation; molecular dynamic; Molecular Dynamics Simulation; Molecular Targeted Therapy; Network Pharmacology; PPAR gamma - antagonists & inhibitors; PPAR gamma - chemistry; PPAR gamma - genetics; PPAR gamma - metabolism; Protein Binding; Protein Interaction Maps - drug effects; src-Family Kinases - antagonists & inhibitors; src-Family Kinases - chemistry; src-Family Kinases - metabolism; molecular docking; molecular dynamic; network pharmacology; Liver cirrhosis; curcumin

Cirrhosis naturally progresses through three stages: compensated, decompensated, and late decompensated, which carry an elevated risk of death. Although curcumin's anti-cirrhosis effects have been studied, underlying mechanism in preventing cirrhosis progression and the correlation between curc...