Functional imaging of COPD by CT and MRI
This commentary reviews the contribution of imaging by CT and MRI to functional assessment in chronic obstructive pulmonary disease (COPD). CT can help individualize the assessment of COPD by quantifying emphysema, air trapping and airway wall thickening, potentially leading to more specific treatme...
Saved in:
| Published in | British journal of radiology Vol. 95; no. 1132; p. 20201005 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
England
The British Institute of Radiology
01.04.2022
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | This commentary reviews the contribution of imaging by CT and MRI to functional assessment in chronic obstructive pulmonary disease (COPD). CT can help individualize the assessment of COPD by quantifying emphysema, air trapping and airway wall thickening, potentially leading to more specific treatments for these distinct components of COPD. Longitudinal changes in these metrics can help assess progression or improvement. On hyperpolarized gas MRI, the apparent diffusion coefficient of provides an index of airspace enlargement reflecting emphysema. Perfusion imaging and measurement of pulmonary vascular volume on non-contrast CT provide insight into the contribution of pulmonary vascular disease to pulmonary impairment. Functional imaging is particularly valuable in detecting early lung dysfunction in subjects with inhalational exposures. |
|---|---|
| AbstractList | This commentary reviews the contribution of imaging by CT and MRI to functional assessment in chronic obstructive pulmonary disease (COPD). CT can help individualize the assessment of COPD by quantifying emphysema, air trapping and airway wall thickening, potentially leading to more specific treatments for these distinct components of COPD. Longitudinal changes in these metrics can help assess progression or improvement. On hyperpolarized gas MRI, the apparent diffusion coefficient of provides an index of airspace enlargement reflecting emphysema. Perfusion imaging and measurement of pulmonary vascular volume on non-contrast CT provide insight into the contribution of pulmonary vascular disease to pulmonary impairment. Functional imaging is particularly valuable in detecting early lung dysfunction in subjects with inhalational exposures. This commentary reviews the contribution of imaging by CT and MRI to functional assessment in chronic obstructive pulmonary disease (COPD). CT can help individualize the assessment of COPD by quantifying emphysema, air trapping and airway wall thickening, potentially leading to more specific treatments for these distinct components of COPD. Longitudinal changes in these metrics can help assess progression or improvement. On hyperpolarized gas MRI, the apparent diffusion coefficient of provides an index of airspace enlargement reflecting emphysema. Perfusion imaging and measurement of pulmonary vascular volume on non-contrast CT provide insight into the contribution of pulmonary vascular disease to pulmonary impairment. Functional imaging is particularly valuable in detecting early lung dysfunction in subjects with inhalational exposures.This commentary reviews the contribution of imaging by CT and MRI to functional assessment in chronic obstructive pulmonary disease (COPD). CT can help individualize the assessment of COPD by quantifying emphysema, air trapping and airway wall thickening, potentially leading to more specific treatments for these distinct components of COPD. Longitudinal changes in these metrics can help assess progression or improvement. On hyperpolarized gas MRI, the apparent diffusion coefficient of provides an index of airspace enlargement reflecting emphysema. Perfusion imaging and measurement of pulmonary vascular volume on non-contrast CT provide insight into the contribution of pulmonary vascular disease to pulmonary impairment. Functional imaging is particularly valuable in detecting early lung dysfunction in subjects with inhalational exposures. |
| Author | Lynch, David A |
| Author_xml | – sequence: 1 givenname: David A surname: Lynch fullname: Lynch, David A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34541865$$D View this record in MEDLINE/PubMed |
| BookMark | eNptUU1Lw0AQXaRiW_XmWXLswdT9zG4ugkSrhUpFKnhbZpNNTUk3NZsK_femtBUVLzMM8-a94b0-6rjKWYQuCB4SKuJrs6iHFFNMMBZHqEckV6FS-K2DehhjGRKqRBf1vV9sRxHjE9RlXHCiItFDg9HapU1ROSiDYgnzws2DKg-S6fNdYDZBMgvAZcHTy_gMHedQenu-76fodXQ_Sx7DyfRhnNxOwpQR3rQVA1AmIxkbkgkwSmYRz3KTxYrF1BowVKUG0pyynKpckJjZCGJuDAcghJ2imx3vam2WNkuta2oo9apuv6s3uoJC_9644l3Pq08dE8EkiVqCwZ6grj7W1jd6WfjUliU4W629pkJyyZSktIVe_tT6FjnY0wLoDpDWlfe1zXVaNLC1q5UuSk2w3mag2wz0IYP26OrP0YH3X_gXomKGow |
| CitedBy_id | crossref_primary_10_1016_j_chest_2023_02_049 crossref_primary_10_1016_S2213_2600_23_00261_8 crossref_primary_10_1097_MCP_0000000000001046 crossref_primary_10_1259_bjr_20229004 crossref_primary_10_1016_j_rmed_2024_107809 crossref_primary_10_1067_j_cpradiol_2024_08_008 |
| Cites_doi | 10.1016/j.ejrad.2004.08.002 10.1164/rccm.201807-1351SO 10.1016/j.rmed.2018.11.014 10.1164/rccm.201506-1196OC 10.1148/radiol.10091937 10.1016/j.crad.2013.11.003 10.1148/radiol.2020192804 10.1164/rccm.201704-0692OC 10.1002/jmri.24104 10.1148/radiol.2020191429 10.1016/j.acra.2018.05.024 10.1056/NEJMoa1106955 10.1164/rccm.201701-0050OC 10.2214/AJR.12.10102 10.1001/jamainternmed.2015.2735 10.1183/13993003.00408-2019 10.1183/13993003.01812-2019 10.1164/rccm.201209-1697OC 10.1164/rccm.201411-2120OC |
| ContentType | Journal Article |
| Copyright | 2022 The Authors. Published by the British Institute of Radiology 2022 The Authors |
| Copyright_xml | – notice: 2022 The Authors. Published by the British Institute of Radiology 2022 The Authors |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1259/bjr.20201005 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Physics |
| DocumentTitleAlternate | Functional imaging of COPD by CT and MRI |
| EISSN | 1748-880X |
| ExternalDocumentID | PMC9153716 34541865 10_1259_bjr_20201005 |
| Genre | Journal Article |
| GroupedDBID | --- .55 0R~ 169 18M 1OC 23N 2WC 33P 36B 4.4 53G 5GY 5RE 5WD 6J9 AANLZ AAUAY AAWTL AAXRX AAYXX ABCUV ABDFA ABEJV ABGNP ABJNI ABNHQ ABQNK ABSZQ ABXGK ABXVV ACAHQ ACCZN ACGFO ACGOF ACXBN ADBBV ADBTR ADIPN ADMGS ADNBA ADOZA ADVOB ADXAS AEGXH AENEX AEUYR AGORE AHMMS AIACR AIAGR AIURR AJNCP ALMA_UNASSIGNED_HOLDINGS ALUQN AMYDB AOIJS BAWUL BCRHZ BFHJK C45 CITATION CS3 DCZOG DIK DRFUL DRMAN DRSTM DU5 E3Z EBD EBS EMB EMOBN F5P GX1 H13 HYE IH2 KBYEO KOP L7B LATKE LEEKS LYRES MXFUL MXMAN MXSTM NU- OCZFY OJZSN OK1 OVD OWPYF P0W P2P ROX SJN SUPJJ SV3 TEORI TR2 TUS TWZ TXR W8F WOQ X7M ZZTAW CGR CUY CVF ECM EIF NPM 7X8 5PM AJAOE WIN |
| ID | FETCH-LOGICAL-c314t-c30aa237679b1d5ab87d64dfbd98392ebab28cbacf23f28f5193e6a94bb4aa113 |
| ISSN | 0007-1285 1748-880X |
| IngestDate | Thu Aug 21 18:07:34 EDT 2025 Thu Jul 10 23:10:49 EDT 2025 Thu Apr 03 07:09:09 EDT 2025 Tue Jul 01 04:12:00 EDT 2025 Thu Apr 24 22:52:11 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1132 |
| Language | English |
| License | This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License http://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted non-commercial reuse, provided the original author and source are credited. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c314t-c30aa237679b1d5ab87d64dfbd98392ebab28cbacf23f28f5193e6a94bb4aa113 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC9153716 |
| PMID | 34541865 |
| PQID | 2574738722 |
| PQPubID | 23479 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_9153716 proquest_miscellaneous_2574738722 pubmed_primary_34541865 crossref_citationtrail_10_1259_bjr_20201005 crossref_primary_10_1259_bjr_20201005 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2022-Apr-01 |
| PublicationDateYYYYMMDD | 2022-04-01 |
| PublicationDate_xml | – month: 04 year: 2022 text: 2022-Apr-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | British journal of radiology |
| PublicationTitleAlternate | Br J Radiol |
| PublicationYear | 2022 |
| Publisher | The British Institute of Radiology |
| Publisher_xml | – name: The British Institute of Radiology |
| References | LaFon (2024050216171444500_b15) 2020; 55 Schroeder (2024050216171444500_b7) 2013; 201 Thomashow (2024050216171444500_b19) 2013; 188 Charbonnier (2024050216171444500_b11) 2019; 146 Kirby (2024050216171444500_b2) 2010; 256 Regan (2024050216171444500_b20) 2019; 6 Pompe (2024050216171444500_b4) 2020; 295 Regan (2024050216171444500_b16) 2015; 175 Bhatt (2024050216171444500_b9) 2017; 196 Labaki (2024050216171444500_b8) 2019; 26 Swift (2024050216171444500_b17) 2005; 54 Hueper (2024050216171444500_b3) 2015; 192 Synn (2024050216171444500_b13) 2019; 54 Bhatt (2024050216171444500_b1) 2019; 199 Kirby (2024050216171444500_b12) 2018; 197 Iyer (2024050216171444500_b14) 2016; 193 Tafti (2024050216171444500_b5) 2020; 297 O'Donnell (2024050216171444500_b10) 2014; 69 Wang (2024050216171444500_b18) 2014; 39 McDonough (2024050216171444500_b6) 2011; 365 |
| References_xml | – volume: 54 start-page: 352 year: 2005 ident: 2024050216171444500_b17 article-title: Emphysematous changes and normal variation in smokers and COPD patients using diffusion 3He MRI publication-title: Eur J Radiol doi: 10.1016/j.ejrad.2004.08.002 – volume: 199 start-page: 286 year: 2019 ident: 2024050216171444500_b1 article-title: Imaging advances in chronic obstructive pulmonary disease. insights from the genetic epidemiology of chronic obstructive pulmonary disease (COPDGene) study publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201807-1351SO – volume: 146 start-page: 36 year: 2019 ident: 2024050216171444500_b11 article-title: Airway wall thickening on CT: relation to smoking status and severity of COPD publication-title: Respir Med doi: 10.1016/j.rmed.2018.11.014 – volume: 193 start-page: 652 year: 2016 ident: 2024050216171444500_b14 article-title: Quantitative dual-energy computed tomography supports a vascular etiology of smoking-induced inflammatory lung disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201506-1196OC – volume: 6 start-page: 233 year: 2019 ident: 2024050216171444500_b20 article-title: Identifying smoking-related disease on lung cancer screening CT scans: increasing the value publication-title: Chronic Obstr Pulm Dis – volume: 256 start-page: 280 year: 2010 ident: 2024050216171444500_b2 article-title: Chronic obstructive pulmonary disease: longitudinal hyperpolarized (3)He MR imaging publication-title: Radiology doi: 10.1148/radiol.10091937 – volume: 69 start-page: 357 year: 2014 ident: 2024050216171444500_b10 article-title: Static end-expiratory and dynamic forced expiratory tracheal collapse in COPD publication-title: Clin Radiol doi: 10.1016/j.crad.2013.11.003 – volume: 297 start-page: 201 year: 2020 ident: 2024050216171444500_b5 article-title: Emphysema index based on hyperpolarized 3He or 129Xe diffusion MRI: performance and comparison with quantitative CT and pulmonary function tests publication-title: Radiology doi: 10.1148/radiol.2020192804 – volume: 197 start-page: 56 year: 2018 ident: 2024050216171444500_b12 article-title: Total airway count on computed tomography and the risk of chronic obstructive pulmonary disease progression. findings from a population-based study publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201704-0692OC – volume: 39 start-page: 77 year: 2014 ident: 2024050216171444500_b18 article-title: Lung injury induced by secondhand smoke exposure detected with hyperpolarized helium-3 diffusion Mr publication-title: J Magn Reson Imaging doi: 10.1002/jmri.24104 – volume: 295 start-page: 218 year: 2020 ident: 2024050216171444500_b4 article-title: Five-year progression of emphysema and air trapping at CT in smokers with and those without chronic obstructive pulmonary disease: results from the COPDGene study publication-title: Radiology doi: 10.1148/radiol.2020191429 – volume: 26 start-page: 217 year: 2019 ident: 2024050216171444500_b8 article-title: Voxel-Wise longitudinal parametric response mapping analysis of chest computed tomography in smokers publication-title: Acad Radiol doi: 10.1016/j.acra.2018.05.024 – volume: 365 start-page: 1567 year: 2011 ident: 2024050216171444500_b6 article-title: Small-airway obstruction and emphysema in chronic obstructive pulmonary disease publication-title: N Engl J Med doi: 10.1056/NEJMoa1106955 – volume: 196 start-page: 569 year: 2017 ident: 2024050216171444500_b9 article-title: Computed tomography measure of lung at risk and lung function decline in chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201701-0050OC – volume: 201 start-page: W460 year: 2013 ident: 2024050216171444500_b7 article-title: Relationships between airflow obstruction and quantitative CT measurements of emphysema, air trapping, and airways in subjects with and without chronic obstructive pulmonary disease publication-title: AJR Am J Roentgenol doi: 10.2214/AJR.12.10102 – volume: 175 start-page: 1539 year: 2015 ident: 2024050216171444500_b16 article-title: Clinical and radiologic disease in smokers with normal spirometry publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2015.2735 – volume: 54 start-page: 1900408 year: 2019 ident: 2024050216171444500_b13 article-title: Radiographic pulmonary vessel volume, lung function and airways disease in the Framingham heart study publication-title: Eur Respir J doi: 10.1183/13993003.00408-2019 – volume: 55 start-page: 1901812 year: 2020 ident: 2024050216171444500_b15 article-title: Pulmonary artery enlargement and mortality risk in moderate to severe COPD: results from COPDGene publication-title: Eur Respir J doi: 10.1183/13993003.01812-2019 – volume: 188 start-page: 60 year: 2013 ident: 2024050216171444500_b19 article-title: Endothelial microparticles in mild chronic obstructive pulmonary disease and emphysema. The multi-ethnic study of atherosclerosis chronic obstructive pulmonary disease study publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201209-1697OC – volume: 192 start-page: 570 year: 2015 ident: 2024050216171444500_b3 article-title: Pulmonary microvascular blood flow in mild chronic obstructive pulmonary disease and emphysema. The MESA COPD study publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201411-2120OC |
| SSID | ssj0007590 |
| Score | 2.4051254 |
| Snippet | This commentary reviews the contribution of imaging by CT and MRI to functional assessment in chronic obstructive pulmonary disease (COPD). CT can help... |
| SourceID | pubmedcentral proquest pubmed crossref |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 20201005 |
| SubjectTerms | Functional imaging of the lung special feature Humans Lung - diagnostic imaging Magnetic Resonance Imaging - methods Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Emphysema - diagnostic imaging Tomography, X-Ray Computed - methods |
| Title | Functional imaging of COPD by CT and MRI |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34541865 https://www.proquest.com/docview/2574738722 https://pubmed.ncbi.nlm.nih.gov/PMC9153716 |
| Volume | 95 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9UwFD_oxLEX0fmxOzeJoCCMurVNm_Zx1I1NvTrGHdy3kqQJXnG9Y-se5l_vSZP0wynoXsKlzU3K-eXjfB-AN-EepykPaaDxfghorPIg01oGIq6kSo0drjIK_emX9OiMfpwn874KXxtd0oj38ucf40rugio-Q1xNlOx_INsNig_wN-KLLSKM7T9hfIiXktPlLc5duSG9U3w9-WC4ymJmvShOj0eWW5fFaJAy4pJXi5F2_fNNbStEtR7vTt3pVAMoVfYeJT64zA86cj04HQ3rT0YW4F1lLczKHoaMZgHu7_nwtLQlMf2qCK1y8tY5jEIVEk98NxlXjb29Da1uBpBcnLeYxDShYZYm_W3U-QieTIscj2OU5-7DgwiFgFZgPv7U3bMssRo0_-UurAGn3h1OvAarfpYx73FLoPjdL3bAaMwewyMnIZB9C_cTuKfqdVidOh-IdXjYOu3Kq6fwrsefOPzJUhODPxE3pJgRxJ8g_s_g7PBgVhwFrvJFIOOQNtjucW78lVguwirhImNVSistqtwwtEpwEWVScKmjWEeZNmy4SnlOhaCcIyrPYaVe1moDCCJkLOMs5UzTnDNkzzjSBefhuBe5nMCOp0kpXVp4U53kR2nEQyRmicQsPTEn8LbrfWHTofyl32tP3hLPK2OE4rVaXl-VeEVQht8TRRN4YcndjeRxmgAbAdF1MLnQx2_qxbc2J7pbKpt3_udLWOu30BasNJfXahv5zUa8apfdLxpjfKA |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Functional+imaging+of+COPD+by+CT+and+MRI&rft.jtitle=British+journal+of+radiology&rft.au=Lynch%2C+David+A&rft.date=2022-04-01&rft.pub=The+British+Institute+of+Radiology&rft.issn=0007-1285&rft.eissn=1748-880X&rft.volume=95&rft.issue=1132&rft_id=info:doi/10.1259%2Fbjr.20201005&rft_id=info%3Apmid%2F34541865&rft.externalDocID=PMC9153716 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0007-1285&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0007-1285&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0007-1285&client=summon |