Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT

• Published in: European journal of pharmaceutics and biopharmaceutics Vol. 184; pp. 7 - 15
• Main Authors: Nave, Micaela, Costa, Francisco J.P., Alves, Cátia G., Lima-Sousa, Rita, Melo, Bruna L., Correia, Ilídio J., de Melo-Diogo, Duarte
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2023
• Subjects: Combinatorial triple therapy; Light responsive nanoparticles; Multifunctional nanomaterials; Photodynamic therapy; Poly(2-ethyl-2-oxazoline); Polymer-IR780 conjugate; MCF-7; PEtOx-IR NPs; DLS; PTT; PDI; ANOVA; FBS; FTIR; SOSG; NHDF; DOX/PEtOx-IR NPs; CLSM; EE; PBS; PEtOx; PDT; Photodynamic therapy; Polymer-IR780 conjugate; Poly(2-ethyl-2-oxazoline); S.D; Light responsive nanoparticles; DMEM-F12; PEtOx-IR conjugate; DOX; ICG; n.s; PEG; PEtOx-SH; NIR; Combinatorial triple therapy; ROS; Multifunctional nanomaterials

[Display omitted] Near infrared (NIR) light-responsive nanomaterials hold potential to mediate combinatorial therapies targeting several cancer hallmarks. When irradiated, these nanomaterials produce reactive oxygen species (photodynamic therapy) and/or a temperature increase (photothermal therapy)....