Cold-inducible RNA-binding protein migrates from the nucleus to the cytoplasm under cold stress in normal human bronchial epithelial cells via TRPM8-mediated mechanism

• Published in: Annals of translational medicine Vol. 9; no. 18; p. 1470
• Main Authors: Mao, Liang-Ping, Jiao, Yan, Xiang, Jian-Hua, Luo, Xin-Wei, He, Qian, Ran, Dan-Hua, Xu, Qing, Lang, Chun-Hui, Chen, Ling-Xiu
• Format: Journal Article
• Language: English
• Published: China AME Publishing Company 01.09.2021
• Subjects: Original; migration; transient receptor potential melastatin 8 (TRPM8); glycogen synthase kinase 3β (GSK3β); cold stress; Cold-inducible RNA-binding protein (CIRP)

Cold-inducible RNA-binding protein (CIRP or hnRNP A18) is a multifunctional stress-responsive protein. Our previous study demonstrated that cold stress increased CIRP expression and migrated from the nucleus to the cytoplasm in airway epithelial cells. However, the mechanism through which CIRP migra...