Gene conversion and polymorphism: Generation of mouse immunoglobulin γ2a chain alleles by differential gene conversion by γ2b chain gene
We have determined the complete nucleotide sequence of the C57BL/6 allele of the mouse immunoglobulin γ2a chain gene. A comparison with the BALB/c γ2a gene for 1912 nucleotides reveals that the two alleles exhibit extensive divergence, since there are 138 single-base-pair differences and 8 insertion...
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| Published in | Cell Vol. 32; no. 2; pp. 515 - 523 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Inc
1983
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| Online Access | Get full text |
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| Abstract | We have determined the complete nucleotide sequence of the C57BL/6 allele of the mouse immunoglobulin γ2a chain gene. A comparison with the BALB/c γ2a gene for 1912 nucleotides reveals that the two alleles exhibit extensive divergence, since there are 138 single-base-pair differences and 8 insertions or deletions. We have compared the two γ2a alleles with the two corresponding γ2b alleles, which differ in only 12 positions. It appears that among the 134 differences between the two γ2a alleles, 70 are at positions where γ2a and γ2b are identical in the BALB/c haplotype and 54 are at positions where γ2a and γ2b are identical in the C57BL/6 haplotype. All these results suggest that nonreciprocal gene conversion between nonallelic genes can introduce sequence homogeneity in linked genes and can generate extensive divergence and polymorphism in allelic genes. We suggest that the γ2a and γ2b gene ancestors freely diverged after duplication, and that the conversion events were promoted by a deletion shortening the distance between the two loci. |
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| AbstractList | We have determined the complete nucleotide sequence of the C57BL/6 allele of the mouse immunoglobulin γ2a chain gene. A comparison with the BALB/c γ2a gene for 1912 nucleotides reveals that the two alleles exhibit extensive divergence, since there are 138 single-base-pair differences and 8 insertions or deletions. We have compared the two γ2a alleles with the two corresponding γ2b alleles, which differ in only 12 positions. It appears that among the 134 differences between the two γ2a alleles, 70 are at positions where γ2a and γ2b are identical in the BALB/c haplotype and 54 are at positions where γ2a and γ2b are identical in the C57BL/6 haplotype. All these results suggest that nonreciprocal gene conversion between nonallelic genes can introduce sequence homogeneity in linked genes and can generate extensive divergence and polymorphism in allelic genes. We suggest that the γ2a and γ2b gene ancestors freely diverged after duplication, and that the conversion events were promoted by a deletion shortening the distance between the two loci. |
| Author | Ollo, Roger Rougeon, Frangois |
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| Cites_doi | 10.1016/0092-8674(81)90131-8 10.1038/296761a0 10.1038/283786a0 10.1016/0092-8674(81)90082-9 10.1146/annurev.ge.09.120175.001513 10.1038/290191a0 10.1146/annurev.bi.47.070178.004215 10.1016/0092-8674(78)90036-3 10.1093/nar/9.2.309 10.1093/nar/3.9.2303 10.1016/0092-8674(79)90072-2 10.1016/0092-8674(80)90168-3 10.1126/science.99815 10.1016/0022-2836(80)90196-5 10.1016/0092-8674(80)90429-8 10.1016/0092-8674(82)90204-5 10.1093/nar/8.14.3143 10.1002/j.1460-2075.1982.tb01220.x 10.1016/0092-8674(80)90426-2 10.1093/nar/10.5.1535 10.1016/S0076-6879(80)65059-9 10.1093/nar/9.16.4099 10.1093/nar/10.13.4071 10.1093/nar/3.9.2387 10.1016/0092-8674(82)90205-7 10.1016/0378-1119(80)90054-2 10.1021/bi00749a003 10.1038/292845a0 10.1126/science.322279 10.1016/0092-8674(81)90302-0 10.1126/science.117549 |
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| References | Smith, Birnstiel (BIB39) 1976; 3 Honjo, Obata, Yamawaki-Kataoka, Kataoka, Kawakami, Takahashi, Mano (BIB14) 1979; 18 Seidman, Leder, Nau, Norman, Leder (BIB34) 1978; 202 Ellison, Berson, Hood (BIB8) 1982; 10 Yamawaki-Kataoka, Kataoka, Takahashi, Obata, Honjo (BIB44) 1980; 283 Messing, Crea, Seeburg (BIB22) 1981; 9 Heidmann, Rougeon (BIB11) 1982; 28 Tucker, Marcu, Newell, Richards, Blattner (BIB42) 1979; 206 Herzenberg, Herzenberg (BIB12) 1979 Maniatis, Hardison, Lacy, Lauer, O'Connell, Quon, Sim, Efstratiadis (BIB19) 1978; 15 Slightom, Blechl, Smithies (BIB38) 1980; 21 Hieter, Max, Seidman, Maizel, Leder (BIB13) 1980; 22 Ollo, Auffray, Sikorav, Rougeon (BIB28) 1981 b; 9 Obata, Kataoka, Nakai, Yamagishi, Takahashi, Yamawaki-Kataoka, Nikaido, Shimizu, Honjo (BIB25) 1981; 78 Panet, Vandesande, Loewen, Khorana, Raae, Lillehaug, Kleppe (BIB29) 1973; 12 Arden, Klein (BIB1) 1982; 79 Dildrop, Bruggemann, Radbruck, Rajewsky, Bayreuther (BIB5) 1982; 1 Ollo, Auffray, Morchamps, Rougeon (BIB27) 1981; 78 Baltimore (BIB2) 1981; 24 Benton, Davis (BIB3) 1977; 196 Loenen, Brammar (BIB18) 1980; 20 Meselson, Radding (BIB21) 1975; 72 Hood, Campbell, Elgin (BIB15) 1975; 9 Maxam, Gilbert (BIB20) 1980; 65 Efstratiadis, Posakony, Maniatis, Lawn, O'Connell, Spritz, Deriel, Forget, Weissman, Slightom, Blechl, Smithies, Baralle, Shoulders, Proudfoot (BIB6) 1980; 21 Sanger, Coulson, Barell, Smith, Roe (BIB32) 1980; 143 Nikaido, Nakai, Honjo (BIB24) 1981; 292 Sobell (BIB40) 1975; 72 Egel (BIB7) 1981; 290 Farnsworth, Goodfliesh, Rodkey, Hood (BIB9) 1976; 73 Ollo, Rougeon (BIB26) 1982; 296 Radding (BIB30) 1978; 47 Roeder, Maki, Traunecker, Tonegawa (BIB31) 1981; 78 Blin, Stafford (BIB4) 1976; 3 Streisinger, Okada, Emrich, Newton, Tsugita, Terzaghi, Inouye (BIB41) 1966; 31 Shimizu, Takahashi, Yaoita, Honjo (BIB36) 1982; 28 Schreier, Bothwell, Mueller-Hill, Baltimore (BIB33) 1981; 78 Miyata, Yasunaga, Yamawaki-Kataoka, Obata, Honjo (BIB23) 1980; 77 Sikorav, Auffray, Rougeon (BIB37) 1980; 8 Klein (BIB17) 1980; 80 Kataoka, Miyata, Honjo (BIB16) 1981; 23 Heidmann, Rougeon (BIB10) 1982; 10 Shen, Slightom, Smithies (BIB35) 1981; 26 Wagner, Radman (BIB43) 1975; 72 Heidmann (10.1016/0092-8674(83)90471-3_BIB10) 1982; 10 Meselson (10.1016/0092-8674(83)90471-3_BIB21) 1975; 72 Seidman (10.1016/0092-8674(83)90471-3_BIB34) 1978; 202 Sikorav (10.1016/0092-8674(83)90471-3_BIB37) 1980; 8 Farnsworth (10.1016/0092-8674(83)90471-3_BIB9) 1976; 73 Slightom (10.1016/0092-8674(83)90471-3_BIB38) 1980; 21 Arden (10.1016/0092-8674(83)90471-3_BIB1) 1982; 79 Schreier (10.1016/0092-8674(83)90471-3_BIB33) 1981; 78 Dildrop (10.1016/0092-8674(83)90471-3_BIB5) 1982; 1 Heidmann (10.1016/0092-8674(83)90471-3_BIB11) 1982; 28 Baltimore (10.1016/0092-8674(83)90471-3_BIB2) 1981; 24 Messing (10.1016/0092-8674(83)90471-3_BIB22) 1981; 9 Hood (10.1016/0092-8674(83)90471-3_BIB15) 1975; 9 Wagner (10.1016/0092-8674(83)90471-3_BIB43) 1975; 72 Ollo (10.1016/0092-8674(83)90471-3_BIB26) 1982; 296 Hieter (10.1016/0092-8674(83)90471-3_BIB13) 1980; 22 Benton (10.1016/0092-8674(83)90471-3_BIB3) 1977; 196 Nikaido (10.1016/0092-8674(83)90471-3_BIB24) 1981; 292 Egel (10.1016/0092-8674(83)90471-3_BIB7) 1981; 290 Maxam (10.1016/0092-8674(83)90471-3_BIB20) 1980; 65 Shimizu (10.1016/0092-8674(83)90471-3_BIB36) 1982; 28 Yamawaki-Kataoka (10.1016/0092-8674(83)90471-3_BIB44) 1980; 283 Herzenberg (10.1016/0092-8674(83)90471-3_BIB12) 1979 Honjo (10.1016/0092-8674(83)90471-3_BIB14) 1979; 18 Klein (10.1016/0092-8674(83)90471-3_BIB17) 1980; 80 Loenen (10.1016/0092-8674(83)90471-3_BIB18) 1980; 20 Panet (10.1016/0092-8674(83)90471-3_BIB29) 1973; 12 Roeder (10.1016/0092-8674(83)90471-3_BIB31) 1981; 78 Sobell (10.1016/0092-8674(83)90471-3_BIB40) 1975; 72 Miyata (10.1016/0092-8674(83)90471-3_BIB23) 1980; 77 Obata (10.1016/0092-8674(83)90471-3_BIB25) 1981; 78 Ollo (10.1016/0092-8674(83)90471-3_BIB28) 1981; 9 Smith (10.1016/0092-8674(83)90471-3_BIB39) 1976; 3 Tucker (10.1016/0092-8674(83)90471-3_BIB42) 1979; 206 Efstratiadis (10.1016/0092-8674(83)90471-3_BIB6) 1980; 21 Kataoka (10.1016/0092-8674(83)90471-3_BIB16) 1981; 23 Sanger (10.1016/0092-8674(83)90471-3_BIB32) 1980; 143 Ellison (10.1016/0092-8674(83)90471-3_BIB8) 1982; 10 Maniatis (10.1016/0092-8674(83)90471-3_BIB19) 1978; 15 Radding (10.1016/0092-8674(83)90471-3_BIB30) 1978; 47 Ollo (10.1016/0092-8674(83)90471-3_BIB27) 1981; 78 Blin (10.1016/0092-8674(83)90471-3_BIB4) 1976; 3 Shen (10.1016/0092-8674(83)90471-3_BIB35) 1981; 26 Streisinger (10.1016/0092-8674(83)90471-3_BIB41) 1966; 31 |
| References_xml | – volume: 290 start-page: 191 year: 1981 end-page: 192 ident: BIB7 article-title: Intergenic conversion and reiterated genes publication-title: Nature contributor: fullname: Egel – volume: 78 start-page: 2442 year: 1981 end-page: 2446 ident: BIB27 article-title: Comparison of mouse immunoglobulin γ2a and γ2b chain genes suggests that exons can be exchanged between genes in a multigenic family publication-title: Proc. Nat. Acad. Sci. USA contributor: fullname: Rougeon – volume: 78 start-page: 2437 year: 1981 end-page: 2441 ident: BIB25 article-title: Structure of a rearranged γ1 gene and its implication to immunoglobulin class switch mechanism publication-title: Proc. Nat. Acad. Sci USA contributor: fullname: Honjo – volume: 23 start-page: 357 year: 1981 end-page: 368 ident: BIB16 article-title: Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes publication-title: Cell contributor: fullname: Honjo – volume: 26 start-page: 191 year: 1981 end-page: 203 ident: BIB35 article-title: A history of the human fetal globin gene duplication publication-title: Cell contributor: fullname: Smithies – volume: 21 start-page: 653 year: 1980 end-page: 668 ident: BIB6 article-title: The structure and evolution of the human β-globin gene family publication-title: Cell contributor: fullname: Proudfoot – volume: 20 start-page: 249 year: 1980 end-page: 259 ident: BIB18 article-title: A bacteriophage lambda vector for cloning large DNA fragments made with several restriction enzymes publication-title: Gene contributor: fullname: Brammar – volume: 80 start-page: 239 year: 1980 end-page: 253 ident: BIB17 article-title: Generation of diversity at MHC loci: implications for T cell receptor repertoires publication-title: Immunology contributor: fullname: Klein – volume: 24 start-page: 592 year: 1981 end-page: 594 ident: BIB2 article-title: Gene conversion: some implications for immunoglobulin genes publication-title: Cell contributor: fullname: Baltimore – volume: 202 start-page: 11 year: 1978 end-page: 17 ident: BIB34 article-title: The structure of cloned immunoglobulin genes suggests a mechanism for generating new sequences publication-title: Science contributor: fullname: Leder – volume: 78 start-page: 4495 year: 1981 end-page: 4499 ident: BIB33 article-title: Multiple differences between the nucleic acid sequences of the IgG2a publication-title: Proc. Nat. Acad. Sci. USA contributor: fullname: Baltimore – volume: 77 start-page: 2143 year: 1980 end-page: 2147 ident: BIB23 article-title: Nucleotide sequence divergence of mouse immunoglobulin γ1 and γ2 chain genes and the hypothesis of intervening sequence-mediated domain transfer publication-title: Proc. Nat. Acad. Sci. USA contributor: fullname: Honjo – start-page: 12.1 year: 1979 end-page: 12.23 ident: BIB12 article-title: Mouse immunoglobulin allotypes: description and special methodology publication-title: Handbook of Experimental Immunology contributor: fullname: Herzenberg – volume: 12 start-page: 5045 year: 1973 end-page: 5049 ident: BIB29 article-title: Physical characterization and simultaneous purification of bacteriophage T4 induced polynucleotide kinase, polynucleotide ligase and deoxyribonucleic acid polymerase publication-title: Biochemistry contributor: fullname: Kleppe – volume: 283 start-page: 786 year: 1980 end-page: 789 ident: BIB44 article-title: Complete nucleotide sequence of immunoglobulin γ2b chain gene cloned from newborn mouse DNA publication-title: Nature contributor: fullname: Honjo – volume: 1 start-page: 635 year: 1982 end-page: 640 ident: BIB5 article-title: Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes publication-title: EMBO J. contributor: fullname: Bayreuther – volume: 10 start-page: 1535 year: 1982 end-page: 1545 ident: BIB10 article-title: Molecular cloning of rabbit γ heavy chain mRNA publication-title: Nucl. Acids Res. contributor: fullname: Rougeon – volume: 18 start-page: 559 year: 1979 end-page: 568 ident: BIB14 article-title: Cloning and complete nucleotide sequence of mouse immunoglobulin γ1 chain gene publication-title: Cell contributor: fullname: Mano – volume: 72 start-page: 3619 year: 1975 end-page: 3622 ident: BIB43 article-title: A mechanism for initiation of genetic recombination publication-title: Proc. Nat. Acad. Sci. USA contributor: fullname: Radman – volume: 28 start-page: 507 year: 1982 end-page: 513 ident: BIB11 article-title: Multiple sequences related to a constant-region kappa light chain gene in the rabbit genome publication-title: Cell contributor: fullname: Rougeon – volume: 3 start-page: 2387 year: 1976 end-page: 2398 ident: BIB39 article-title: A simple method for DNA restriction site mapping publication-title: Nucl. Acids Res. contributor: fullname: Birnstiel – volume: 9 start-page: 4099 year: 1981 b end-page: 4109 ident: BIB28 article-title: Mouse heavy chain variable regions: nucleotide sequence of a germ line gene segment publication-title: Nucl. Acids Res. contributor: fullname: Rougeon – volume: 78 start-page: 474 year: 1981 end-page: 478 ident: BIB31 article-title: Linkage of the four γ subclass heavy chain genes publication-title: Proc. Nat. Acad. Sci. USA contributor: fullname: Tonegawa – volume: 21 start-page: 627 year: 1980 end-page: 638 ident: BIB38 article-title: Human fetal publication-title: Cell contributor: fullname: Smithies – volume: 79 start-page: 2332 year: 1982 end-page: 2346 ident: BIB1 article-title: Biochemical comparison of major histocompatibility complex molecules from different subspecies of Mus musculus: evidence for trans-specific evolution of alleles publication-title: Proc. Nat. Acad. Sci. USA contributor: fullname: Klein – volume: 9 start-page: 305 year: 1975 end-page: 353 ident: BIB15 article-title: The organization, expression and evolution of antibody genes and other multigene families publication-title: Ann. Rev. Genet. contributor: fullname: Elgin – volume: 72 start-page: 279 year: 1975 end-page: 282 ident: BIB40 article-title: A mechanism to activate branch migration between homologous DNA molecules in genetic recombination publication-title: Proc. Nat. Acad. Sci. USA contributor: fullname: Sobell – volume: 10 start-page: 4071 year: 1982 end-page: 4079 ident: BIB8 article-title: The nucleotide sequence of a human immunoglobulin Cγ1 gene publication-title: Nucl. Acids Res. contributor: fullname: Hood – volume: 15 start-page: 687 year: 1978 end-page: 701 ident: BIB19 article-title: The isolation of structural genes from libraries of eucaryotic DNA publication-title: Cell contributor: fullname: Efstratiadis – volume: 9 start-page: 309 year: 1981 end-page: 321 ident: BIB22 article-title: A system for shotgun DNA sequencing publication-title: Nucl. Acids Res. contributor: fullname: Seeburg – volume: 47 start-page: 847 year: 1978 end-page: 880 ident: BIB30 article-title: Genetic recombination: strand transfer and mismatch repair publication-title: Ann. Rev. Biochem. contributor: fullname: Radding – volume: 31 start-page: 77 year: 1966 end-page: 84 ident: BIB41 article-title: Frameshift mutations and the genetic code publication-title: Cold Spring Harbor Symp. Quant. Biol. contributor: fullname: Inouye – volume: 296 start-page: 761 year: 1982 end-page: 763 ident: BIB26 article-title: Mouse immunoglobulin allotypes: post duplication divergence of γ2b chain genes publication-title: Nature contributor: fullname: Rougeon – volume: 196 start-page: 180 year: 1977 end-page: 182 ident: BIB3 article-title: Screening γgt recombinant clones by hybridization to single plaques in situ publication-title: Science contributor: fullname: Davis – volume: 72 start-page: 358 year: 1975 end-page: 361 ident: BIB21 article-title: A general model for genetic recombination publication-title: Proc. Nat. Acad. Sci. USA contributor: fullname: Radding – volume: 22 start-page: 197 year: 1980 end-page: 207 ident: BIB13 article-title: Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments publication-title: Cell contributor: fullname: Leder – volume: 8 start-page: 3143 year: 1980 end-page: 3155 ident: BIB37 article-title: Structure of the constant and 3′ untranslated region of the murine Balb/C γ2a heavy chain messenger RNA publication-title: Nucl. Acids Res. contributor: fullname: Rougeon – volume: 65 start-page: 499 year: 1980 end-page: 560 ident: BIB20 article-title: Sequencing end-labeled DNA with base-specific chemical cleavages publication-title: Meth. Enzymol. contributor: fullname: Gilbert – volume: 73 start-page: 1293 year: 1976 end-page: 1296 ident: BIB9 article-title: Immunoglobulin allotypes of rabbit kappa chains: polymorphism of a control mechanism regulating closely linked duplicated genes? publication-title: Proc. Nat. Acad. Sci. USA contributor: fullname: Hood – volume: 292 start-page: 845 year: 1981 end-page: 848 ident: BIB24 article-title: Switch region of immunoglobulin C gene is composed of simple tandem repetitive sequences publication-title: Nature contributor: fullname: Honjo – volume: 143 start-page: 161 year: 1980 end-page: 178 ident: BIB32 article-title: Cloning in single stranded bacteriophase as an aid to rapid DNA sequencing publication-title: J. Mol. Biol. contributor: fullname: Roe – volume: 206 start-page: 1303 year: 1979 end-page: 1306 ident: BIB42 article-title: Sequence of the cloned gene for the constant region of murine γ2b immunoglobulin heavy chain publication-title: Science contributor: fullname: Blattner – volume: 3 start-page: 2303 year: 1976 end-page: 2308 ident: BIB4 article-title: A general method for isolation of high molecular weight DNA from eukaryotes publication-title: Nucl. Acids Res. contributor: fullname: Stafford – volume: 28 start-page: 499 year: 1982 end-page: 506 ident: BIB36 article-title: Organization of the constant-region gene family of the mouse immunoglobulin heavy chain publication-title: Cell contributor: fullname: Honjo – volume: 23 start-page: 357 year: 1981 ident: 10.1016/0092-8674(83)90471-3_BIB16 article-title: Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes publication-title: Cell doi: 10.1016/0092-8674(81)90131-8 contributor: fullname: Kataoka – volume: 296 start-page: 761 year: 1982 ident: 10.1016/0092-8674(83)90471-3_BIB26 article-title: Mouse immunoglobulin allotypes: post duplication divergence of γ2b chain genes publication-title: Nature doi: 10.1038/296761a0 contributor: fullname: Ollo – volume: 78 start-page: 2437 year: 1981 ident: 10.1016/0092-8674(83)90471-3_BIB25 article-title: Structure of a rearranged γ1 gene and its implication to immunoglobulin class switch mechanism contributor: fullname: Obata – volume: 73 start-page: 1293 year: 1976 ident: 10.1016/0092-8674(83)90471-3_BIB9 article-title: Immunoglobulin allotypes of rabbit kappa chains: polymorphism of a control mechanism regulating closely linked duplicated genes? contributor: fullname: Farnsworth – volume: 283 start-page: 786 year: 1980 ident: 10.1016/0092-8674(83)90471-3_BIB44 article-title: Complete nucleotide sequence of immunoglobulin γ2b chain gene cloned from newborn mouse DNA publication-title: Nature doi: 10.1038/283786a0 contributor: fullname: Yamawaki-Kataoka – volume: 24 start-page: 592 year: 1981 ident: 10.1016/0092-8674(83)90471-3_BIB2 article-title: Gene conversion: some implications for immunoglobulin genes publication-title: Cell doi: 10.1016/0092-8674(81)90082-9 contributor: fullname: Baltimore – volume: 72 start-page: 358 year: 1975 ident: 10.1016/0092-8674(83)90471-3_BIB21 article-title: A general model for genetic recombination contributor: fullname: Meselson – volume: 9 start-page: 305 year: 1975 ident: 10.1016/0092-8674(83)90471-3_BIB15 article-title: The organization, expression and evolution of antibody genes and other multigene families publication-title: Ann. Rev. Genet. doi: 10.1146/annurev.ge.09.120175.001513 contributor: fullname: Hood – volume: 72 start-page: 279 year: 1975 ident: 10.1016/0092-8674(83)90471-3_BIB40 article-title: A mechanism to activate branch migration between homologous DNA molecules in genetic recombination contributor: fullname: Sobell – volume: 290 start-page: 191 year: 1981 ident: 10.1016/0092-8674(83)90471-3_BIB7 article-title: Intergenic conversion and reiterated genes publication-title: Nature doi: 10.1038/290191a0 contributor: fullname: Egel – volume: 47 start-page: 847 year: 1978 ident: 10.1016/0092-8674(83)90471-3_BIB30 article-title: Genetic recombination: strand transfer and mismatch repair publication-title: Ann. Rev. Biochem. doi: 10.1146/annurev.bi.47.070178.004215 contributor: fullname: Radding – volume: 15 start-page: 687 year: 1978 ident: 10.1016/0092-8674(83)90471-3_BIB19 article-title: The isolation of structural genes from libraries of eucaryotic DNA publication-title: Cell doi: 10.1016/0092-8674(78)90036-3 contributor: fullname: Maniatis – volume: 9 start-page: 309 year: 1981 ident: 10.1016/0092-8674(83)90471-3_BIB22 article-title: A system for shotgun DNA sequencing publication-title: Nucl. Acids Res. doi: 10.1093/nar/9.2.309 contributor: fullname: Messing – volume: 3 start-page: 2303 year: 1976 ident: 10.1016/0092-8674(83)90471-3_BIB4 article-title: A general method for isolation of high molecular weight DNA from eukaryotes publication-title: Nucl. Acids Res. doi: 10.1093/nar/3.9.2303 contributor: fullname: Blin – volume: 18 start-page: 559 year: 1979 ident: 10.1016/0092-8674(83)90471-3_BIB14 article-title: Cloning and complete nucleotide sequence of mouse immunoglobulin γ1 chain gene publication-title: Cell doi: 10.1016/0092-8674(79)90072-2 contributor: fullname: Honjo – volume: 79 start-page: 2332 year: 1982 ident: 10.1016/0092-8674(83)90471-3_BIB1 article-title: Biochemical comparison of major histocompatibility complex molecules from different subspecies of Mus musculus: evidence for trans-specific evolution of alleles contributor: fullname: Arden – volume: 22 start-page: 197 year: 1980 ident: 10.1016/0092-8674(83)90471-3_BIB13 article-title: Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments publication-title: Cell doi: 10.1016/0092-8674(80)90168-3 contributor: fullname: Hieter – volume: 202 start-page: 11 year: 1978 ident: 10.1016/0092-8674(83)90471-3_BIB34 article-title: The structure of cloned immunoglobulin genes suggests a mechanism for generating new sequences publication-title: Science doi: 10.1126/science.99815 contributor: fullname: Seidman – volume: 78 start-page: 2442 year: 1981 ident: 10.1016/0092-8674(83)90471-3_BIB27 article-title: Comparison of mouse immunoglobulin γ2a and γ2b chain genes suggests that exons can be exchanged between genes in a multigenic family contributor: fullname: Ollo – volume: 143 start-page: 161 year: 1980 ident: 10.1016/0092-8674(83)90471-3_BIB32 article-title: Cloning in single stranded bacteriophase as an aid to rapid DNA sequencing publication-title: J. Mol. Biol. doi: 10.1016/0022-2836(80)90196-5 contributor: fullname: Sanger – volume: 21 start-page: 653 year: 1980 ident: 10.1016/0092-8674(83)90471-3_BIB6 article-title: The structure and evolution of the human β-globin gene family publication-title: Cell doi: 10.1016/0092-8674(80)90429-8 contributor: fullname: Efstratiadis – volume: 28 start-page: 499 year: 1982 ident: 10.1016/0092-8674(83)90471-3_BIB36 article-title: Organization of the constant-region gene family of the mouse immunoglobulin heavy chain publication-title: Cell doi: 10.1016/0092-8674(82)90204-5 contributor: fullname: Shimizu – volume: 8 start-page: 3143 year: 1980 ident: 10.1016/0092-8674(83)90471-3_BIB37 article-title: Structure of the constant and 3′ untranslated region of the murine Balb/C γ2a heavy chain messenger RNA publication-title: Nucl. Acids Res. doi: 10.1093/nar/8.14.3143 contributor: fullname: Sikorav – volume: 1 start-page: 635 year: 1982 ident: 10.1016/0092-8674(83)90471-3_BIB5 article-title: Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes publication-title: EMBO J. doi: 10.1002/j.1460-2075.1982.tb01220.x contributor: fullname: Dildrop – volume: 72 start-page: 3619 year: 1975 ident: 10.1016/0092-8674(83)90471-3_BIB43 article-title: A mechanism for initiation of genetic recombination contributor: fullname: Wagner – volume: 78 start-page: 474 year: 1981 ident: 10.1016/0092-8674(83)90471-3_BIB31 article-title: Linkage of the four γ subclass heavy chain genes contributor: fullname: Roeder – volume: 21 start-page: 627 year: 1980 ident: 10.1016/0092-8674(83)90471-3_BIB38 article-title: Human fetal Gγ- and Aγ-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes publication-title: Cell doi: 10.1016/0092-8674(80)90426-2 contributor: fullname: Slightom – volume: 10 start-page: 1535 year: 1982 ident: 10.1016/0092-8674(83)90471-3_BIB10 article-title: Molecular cloning of rabbit γ heavy chain mRNA publication-title: Nucl. Acids Res. doi: 10.1093/nar/10.5.1535 contributor: fullname: Heidmann – volume: 65 start-page: 499 year: 1980 ident: 10.1016/0092-8674(83)90471-3_BIB20 article-title: Sequencing end-labeled DNA with base-specific chemical cleavages publication-title: Meth. Enzymol. doi: 10.1016/S0076-6879(80)65059-9 contributor: fullname: Maxam – volume: 9 start-page: 4099 year: 1981 ident: 10.1016/0092-8674(83)90471-3_BIB28 article-title: Mouse heavy chain variable regions: nucleotide sequence of a germ line gene segment publication-title: Nucl. Acids Res. doi: 10.1093/nar/9.16.4099 contributor: fullname: Ollo – volume: 77 start-page: 2143 year: 1980 ident: 10.1016/0092-8674(83)90471-3_BIB23 article-title: Nucleotide sequence divergence of mouse immunoglobulin γ1 and γ2 chain genes and the hypothesis of intervening sequence-mediated domain transfer contributor: fullname: Miyata – volume: 10 start-page: 4071 year: 1982 ident: 10.1016/0092-8674(83)90471-3_BIB8 article-title: The nucleotide sequence of a human immunoglobulin Cγ1 gene publication-title: Nucl. Acids Res. doi: 10.1093/nar/10.13.4071 contributor: fullname: Ellison – volume: 3 start-page: 2387 year: 1976 ident: 10.1016/0092-8674(83)90471-3_BIB39 article-title: A simple method for DNA restriction site mapping publication-title: Nucl. Acids Res. doi: 10.1093/nar/3.9.2387 contributor: fullname: Smith – volume: 31 start-page: 77 year: 1966 ident: 10.1016/0092-8674(83)90471-3_BIB41 article-title: Frameshift mutations and the genetic code contributor: fullname: Streisinger – volume: 78 start-page: 4495 year: 1981 ident: 10.1016/0092-8674(83)90471-3_BIB33 article-title: Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse contributor: fullname: Schreier – volume: 28 start-page: 507 year: 1982 ident: 10.1016/0092-8674(83)90471-3_BIB11 article-title: Multiple sequences related to a constant-region kappa light chain gene in the rabbit genome publication-title: Cell doi: 10.1016/0092-8674(82)90205-7 contributor: fullname: Heidmann – volume: 80 start-page: 239 year: 1980 ident: 10.1016/0092-8674(83)90471-3_BIB17 article-title: Generation of diversity at MHC loci: implications for T cell receptor repertoires contributor: fullname: Klein – volume: 20 start-page: 249 year: 1980 ident: 10.1016/0092-8674(83)90471-3_BIB18 article-title: A bacteriophage lambda vector for cloning large DNA fragments made with several restriction enzymes publication-title: Gene doi: 10.1016/0378-1119(80)90054-2 contributor: fullname: Loenen – start-page: 12.1 year: 1979 ident: 10.1016/0092-8674(83)90471-3_BIB12 article-title: Mouse immunoglobulin allotypes: description and special methodology contributor: fullname: Herzenberg – volume: 12 start-page: 5045 year: 1973 ident: 10.1016/0092-8674(83)90471-3_BIB29 article-title: Physical characterization and simultaneous purification of bacteriophage T4 induced polynucleotide kinase, polynucleotide ligase and deoxyribonucleic acid polymerase publication-title: Biochemistry doi: 10.1021/bi00749a003 contributor: fullname: Panet – volume: 292 start-page: 845 year: 1981 ident: 10.1016/0092-8674(83)90471-3_BIB24 article-title: Switch region of immunoglobulin C gene is composed of simple tandem repetitive sequences publication-title: Nature doi: 10.1038/292845a0 contributor: fullname: Nikaido – volume: 196 start-page: 180 year: 1977 ident: 10.1016/0092-8674(83)90471-3_BIB3 article-title: Screening γgt recombinant clones by hybridization to single plaques in situ publication-title: Science doi: 10.1126/science.322279 contributor: fullname: Benton – volume: 26 start-page: 191 year: 1981 ident: 10.1016/0092-8674(83)90471-3_BIB35 article-title: A history of the human fetal globin gene duplication publication-title: Cell doi: 10.1016/0092-8674(81)90302-0 contributor: fullname: Shen – volume: 206 start-page: 1303 year: 1979 ident: 10.1016/0092-8674(83)90471-3_BIB42 article-title: Sequence of the cloned gene for the constant region of murine γ2b immunoglobulin heavy chain publication-title: Science doi: 10.1126/science.117549 contributor: fullname: Tucker |
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| Snippet | We have determined the complete nucleotide sequence of the C57BL/6 allele of the mouse immunoglobulin γ2a chain gene. A comparison with the BALB/c γ2a gene for... |
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| Title | Gene conversion and polymorphism: Generation of mouse immunoglobulin γ2a chain alleles by differential gene conversion by γ2b chain gene |
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