Zeolite Imidazolate Framework-Based Platform for the Electrochemical Detection of Epinephrine

• Published in: Journal of the Electrochemical Society Vol. 170; no. 10; pp. 107504 - 107510
• Main Authors: Soosaimanickam, Charlin, Sakthivel, Arunkumar, Murugavel, Kathiresan, Alwarappan, Subbiah
• Format: Journal Article
• Language: English
• Published: IOP Publishing 01.10.2023
• Subjects: adrenaline; electrochemical sensor; epinephrine; metal organic frameworks; zeolite imidazole framework
• ISSN: 0013-4651; 1945-7111
• DOI: 10.1149/1945-7111/acff21

In this study, we employed a zeolite imidazolate framework (ZIF-67) modified glassy carbon electrode (GCE) as a platform for the electrochemical detection of epinephrine. The ZIF-67 modified glassy carbon electrode (GCE) exhibited excellent electrocatalytic activity towards the detection of epinephrine in phosphate buffer (PBS, pH 7.0). The proposed ZIF-67 displayed superior electrocatalytic activity towards the oxidation of epinephrine in the 0.5−50 μ M linear range with a limit of detection (LOD) of 2.1 μ M, and a sensitivity of 0.06 μ A μ M −1 cm −2 . The efficacy of the proposed biosensor was demonstrated for the direct determination of epinephrine from serum and urine samples. All these results confirmed the usefulness of ZIF-67 modified electrodes for clinical analysis.