Pharmacogenetic and safety analysis of cinacalcet hydrochloride in healthy Chinese subjects

• Published in: Annals of translational medicine Vol. 8; no. 21; p. 1385
• Main Authors: Liu, Yang-Jie, Sun, Lu-Ning, Cheng, Zi-Ping, Qian, Yi, Ma, Zeng-Qing, Zhang, Xue-Hui, Zhang, Hong-Wen, Xie, Li-Jun, Yu, Lei, Yuan, Zi-Qing-Yun, Liu, Yun, Wang, Yong-Qing
• Format: Journal Article
• Language: English
• Published: China AME Publishing Company 01.11.2020
• Subjects: Original; calcium-sensitive receptors (CASR); CYP3A4; Cinacalcet; pharmacokinetics (PK); bioequivalence

Our study aims to explore the effect of genetics on the pharmacodynamics (PD) and pharmacokinetics (PK) of cinacalcet in healthy Chinese subjects; to investigate the effect of dietary factors on cinacalcet, and to evaluate the safety of cinacalcet under fasting and non-fasting conditions using a bio...