Novel aspects of endometrial function: a biological sensor of embryo quality and driver of pregnancy success

Successful pregnancy depends on complex biological processes that are regulated temporally and spatially throughout gestation. The molecular basis of these processes have been examined in relation to gamete quality, early blastocyst development and placental function, and data have been generated sh...

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Published inReproduction fertility and development Vol. 24; no. 1; p. 68
Main Authors Sandra, Olivier, Mansouri-Attia, Nadéra, Lea, Richard G
Format Journal Article
LanguageEnglish
Published Australia 01.01.2012
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Abstract Successful pregnancy depends on complex biological processes that are regulated temporally and spatially throughout gestation. The molecular basis of these processes have been examined in relation to gamete quality, early blastocyst development and placental function, and data have been generated showing perturbations of these developmental stages by environmental insults or embryo biotechnologies. The developmental period falling between the entry of the blastocyst into the uterine cavity to implantation has also been examined in terms of the biological function of the endometrium. Indeed several mechanisms underlying uterine receptivity, controlled by maternal factors, and the maternal recognition of pregnancy, requiring conceptus-produced signals, have been clarified. Nevertheless, recent data based on experimental perturbations have unveiled unexpected biological properties of the endometrium (sensor/driver) that make this tissue a dynamic and reactive entity. Persistent or transient modifications in organisation and functionality of the endometrium can dramatically affect pre-implantation embryo trajectory through epigenetic alterations with lasting consequences on later stages of pregnancy, including placentation, fetal development, pregnancy outcome and post-natal health. Developing diagnostic and prognostic tools based on endometrial factors may enable the assessment of maternal reproductive capacity and/or the developmental potential of the embryo, particularly when assisted reproductive technologies are applied.
AbstractList Successful pregnancy depends on complex biological processes that are regulated temporally and spatially throughout gestation. The molecular basis of these processes have been examined in relation to gamete quality, early blastocyst development and placental function, and data have been generated showing perturbations of these developmental stages by environmental insults or embryo biotechnologies. The developmental period falling between the entry of the blastocyst into the uterine cavity to implantation has also been examined in terms of the biological function of the endometrium. Indeed several mechanisms underlying uterine receptivity, controlled by maternal factors, and the maternal recognition of pregnancy, requiring conceptus-produced signals, have been clarified. Nevertheless, recent data based on experimental perturbations have unveiled unexpected biological properties of the endometrium (sensor/driver) that make this tissue a dynamic and reactive entity. Persistent or transient modifications in organisation and functionality of the endometrium can dramatically affect pre-implantation embryo trajectory through epigenetic alterations with lasting consequences on later stages of pregnancy, including placentation, fetal development, pregnancy outcome and post-natal health. Developing diagnostic and prognostic tools based on endometrial factors may enable the assessment of maternal reproductive capacity and/or the developmental potential of the embryo, particularly when assisted reproductive technologies are applied.
Author Lea, Richard G
Mansouri-Attia, Nadéra
Sandra, Olivier
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Snippet Successful pregnancy depends on complex biological processes that are regulated temporally and spatially throughout gestation. The molecular basis of these...
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StartPage 68
SubjectTerms Animals
Embryo Implantation - physiology
Embryonic Development - physiology
Endometrium - physiology
Epigenesis, Genetic - physiology
Female
Humans
Mice
Models, Animal
Pregnancy - physiology
Pregnancy Outcome
Pregnancy, Animal - physiology
Ruminants
Title Novel aspects of endometrial function: a biological sensor of embryo quality and driver of pregnancy success
URI https://www.ncbi.nlm.nih.gov/pubmed/22394719
Volume 24
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