A subunit vaccine based on Brucella rBP26 induces Th1 immune responses and M1 macrophage activation

• Published in: Acta biochimica et biophysica Sinica Vol. 56; no. 6; pp. 879 - 891
• Main Authors: Wen, Jia, Li, Zihua, Lv, Yongxue, Ding, Shuqin, Zhu, Yazhou, Yang, Jihui, Tang, Jing, Zhu, Mingxing, Zhao, Yinqi, Zhao, Wei
• Format: Journal Article
• Language: English
• Published: China China Science Publishing & Media Ltd 25.06.2024
• Subjects: Adjuvants, Immunologic - pharmacology; Animals; Bacterial Proteins - genetics; Bacterial Proteins - immunology; BP26; Brucella - immunology; Brucella Vaccine - immunology; Brucellosis - immunology; Brucellosis - prevention & control; CD8-Positive T-Lymphocytes - immunology; Cytokines - immunology; Cytokines - metabolism; Female; immunogenicity; M1 macrophage; Macrophage Activation - drug effects; Macrophage Activation - immunology; Macrophages - immunology; Membrane Proteins; Mice; Mice, Inbred BALB C; Oligodeoxyribonucleotides - immunology; recombinant protein vaccine; Th1 Cells - immunology; Th1 immune responses; Vaccines, Subunit - immunology; Th1 immune responses; recombinant protein vaccine; M1 macrophage; BP26; immunogenicity

Brucellosis is a global zoonotic infection caused by bacteria, which poses a significant burden on society. While transmission prevention is currently the most effective method, the absence of a licenced vaccine for humans necessitates the urgent development of a safe and effective vaccine. Recombin...