Splicing-specific transcriptome-wide association uncovers genetic mechanisms for schizophrenia

• Published in: American journal of human genetics Vol. 111; no. 8; pp. 1573 - 1587
• Main Authors: Hervoso, Jonatan L., Amoah, Kofi, Dodson, Jack, Choudhury, Mudra, Bhattacharya, Arjun, Quinones-Valdez, Giovanni, Pasaniuc, Bogdan, Xiao, Xinshu
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 08.08.2024; Elsevier
• Subjects: alternative RNA splicing; fine mapping; genetic variations; neurological disorders; RNA binding proteins; TWAS; TWAS; fine mapping; genetic variations; alternative RNA splicing; neurological disorders; RNA binding proteins

Recent studies have highlighted the essential role of RNA splicing, a key mechanism of alternative RNA processing, in establishing connections between genetic variations and disease. Genetic loci influencing RNA splicing variations show considerable influence on complex traits, possibly surpassing t...