Morphological, Biochemical, and Functional Study of Viral Replication Compartments Isolated from Adenovirus-Infected Cells

• Vydáno v: Journal of virology Ročník 90; číslo 7; s. 3411 - 3427
• Hlavní autoři: Hidalgo, Paloma, Anzures, Lourdes, Hernández-Mendoza, Armando, Guerrero, Adán, Wood, Christopher D., Valdés, Margarita, Dobner, Thomas, Gonzalez, Ramón A.
• Typ dokumentu: Článek v odborném časopise
• Jazyk: angličtina
• Vydáno: United States American Society for Microbiology 01.04.2016
• Témata: Adenoviridae Infections - virology; Adenoviruses, Human - genetics; Adenoviruses, Human - physiology; Cell Line; Cell Nucleus; Computational Biology; DNA, Viral - genetics; DNA-Binding Proteins; Genome, Viral - genetics; HEK293 Cells; Humans; RNA Processing, Post-Transcriptional - genetics; RNA Splicing - genetics; RNA, Messenger - genetics; RNA, Viral - genetics; Virus Replication - genetics; Virus Replication - physiology; Virus-Cell Interactions
• On-line přístup: Získat plný text
• ISSN: 0022-538X; 1098-5514; 1098-5514
• DOI: 10.1128/JVI.00033-16

Adenovirus (Ad) replication compartments (RC) are nuclear microenvironments where the viral genome is replicated and a coordinated program of late gene expression is established. These virus-induced nuclear sites seem to behave as central hubs for the regulation of virus-host cell interactions, sinc...