Conjunctival changes induced by prostaglandin analogues and timolol maleate: a histomorphometric study

• Published in: Arquivos brasileiros de oftalmologia Vol. 70; no. 6; pp. 910 - 916
• Main Authors: Russ, Heloisa Helena Abil, Costa, Vital Paulino, Ferreira, Fabiano Montiani, Valgas, Sílvia Regina, Correa Neto, Mario Adolfo, Strobel, Eduardo von Linsingen, Truppel, Jessé Henrique
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Conselho Brasileiro de Oftalmologia 01.12.2007
• Subjects: Amides - administration & dosage; Amides - adverse effects; Analysis of Variance; Animals; Antihypertensive Agents - administration & dosage; Antihypertensive Agents - adverse effects; Benzalkonium Compounds - administration & dosage; Benzalkonium Compounds - adverse effects; Bimatoprost; Biopsy; Cloprostenol - administration & dosage; Cloprostenol - adverse effects; Cloprostenol - analogs & derivatives; Conjunctiva - drug effects; Conjunctiva - pathology; Disease Models, Animal; Female; Goblet Cells - drug effects; Goblet Cells - pathology; Ophthalmic Solutions - administration & dosage; OPHTHALMOLOGY; Prostaglandins F, Synthetic - administration & dosage; Prostaglandins F, Synthetic - adverse effects; Prostaglandins, Synthetic - administration & dosage; Prostaglandins, Synthetic - adverse effects; Rabbits; Staining and Labeling; Time Factors; Timolol - administration & dosage; Timolol - adverse effects; Travoprost; Glaucoma; synthetic; Rabbits; Prostaglandins; Conjuntiva; Coelhos; Conjunctiva; Prostaglandinas sintéticas; Timolol

To compare histological changes induced by antiglaucoma medications in the rabbit conjunctiva. Fifty New Zealand rabbits were divided in 5 groups of 10 animals. The left eyes were treated daily with one drop of bimatoprost 0.03%, travoprost 0.004%, latanoprost 0.005%, timolol maleate 0.5% or artific...