Conjunctival changes induced by prostaglandin analogues and timolol maleate: a histomorphometric study
To compare histological changes induced by antiglaucoma medications in the rabbit conjunctiva. Fifty New Zealand rabbits were divided in 5 groups of 10 animals. The left eyes were treated daily with one drop of bimatoprost 0.03%, travoprost 0.004%, latanoprost 0.005%, timolol maleate 0.5% or artific...
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Published in | Arquivos brasileiros de oftalmologia Vol. 70; no. 6; pp. 910 - 916 |
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Abstract | To compare histological changes induced by antiglaucoma medications in the rabbit conjunctiva.
Fifty New Zealand rabbits were divided in 5 groups of 10 animals. The left eyes were treated daily with one drop of bimatoprost 0.03%, travoprost 0.004%, latanoprost 0.005%, timolol maleate 0.5% or artificial tears containing benzalkonium chloride (BAK) for 30 days. The right eyes served as controls. Superior limbic conjunctival biopsies were performed at the 8th and 30th day in 5 rabbits of each group. The conjunctiva was fixed with 10% formaldehyde, followed by HE and PAS staining. Morphohistometric quantitative analyses were performed to evaluate the following parameters: inflammatory infiltrate, epithelial thickness, number of goblet cells, diameter and number of blood vessels.
At the 8th and 30th posttreatment days, all groups, except one that received artificial tears, exhibited a diffuse inflammatory infiltrate, composed by lymphocytes and neutrophils, which was denser in the timolol group than in the prostaglandin (PG) analogues groups. At the 30th day, the timolol group also showed an increased subepithelial collagen density and a significant increase in epithelial thickness (p=0.0035). The goblet cell density was significantly increased at the 8th day in the group treated with travoprost (p=0.0006), and at the 30th day in those treated with bimatoprost (p=0.0021) and latanoprost (p=0.009).
Although a moderate, diffuse inflammatory infiltrate was observed in PG-treated eyes, no changes in conjunctival epithelial thickness or subconjunctival collagen density were observed with these medications, suggesting that these drugs induce fewer changes than timolol maleate in the rabbit conjunctiva. |
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AbstractList | PURPOSE: To compare histological changes induced by antiglaucoma medications in the rabbit conjunctiva. METHODS: Fifty New Zealand rabbits were divided in 5 groups of 10 animals. The left eyes were treated daily with one drop of bimatoprost 0.03%, travoprost 0.004%, latanoprost 0.005%, timolol maleate 0.5% or artificial tears containing benzalkonium chloride (BAK) for 30 days. The right eyes served as controls. Superior limbic conjunctival biopsies were performed at the 8th and 30th day in 5 rabbits of each group. The conjunctiva was fixed with 10% formaldehyde, followed by HE and PAS staining. Morphohistometric quantitative analyses were performed to evaluate the following parameters: inflammatory infiltrate, epithelial thickness, number of goblet cells, diameter and number of blood vessels. RESULTS: At the 8th and 30th posttreatment days, all groups, except one that received artificial tears, exhibited a diffuse inflammatory infiltrate, composed by lymphocytes and neutrophils, which was denser in the timolol group than in the prostaglandin (PG) analogues groups. At the 30th day, the timolol group also showed an increased subepithelial collagen density and a significant increase in epithelial thickness (p=0.0035). The goblet cell density was significantly increased at the 8th day in the group treated with travoprost (p=0.0006), and at the 30th day in those treated with bimatoprost (p=0.0021) and latanoprost (p=0.009). CONCLUSIONS: Although a moderate, diffuse inflammatory infiltrate was observed in PG-treated eyes, no changes in conjunctival epithelial thickness or subconjunctival collagen density were observed with these medications, suggesting that these drugs induce fewer changes than timolol maleate in the rabbit conjunctiva. To compare histological changes induced by antiglaucoma medications in the rabbit conjunctiva. Fifty New Zealand rabbits were divided in 5 groups of 10 animals. The left eyes were treated daily with one drop of bimatoprost 0.03%, travoprost 0.004%, latanoprost 0.005%, timolol maleate 0.5% or artificial tears containing benzalkonium chloride (BAK) for 30 days. The right eyes served as controls. Superior limbic conjunctival biopsies were performed at the 8th and 30th day in 5 rabbits of each group. The conjunctiva was fixed with 10% formaldehyde, followed by HE and PAS staining. Morphohistometric quantitative analyses were performed to evaluate the following parameters: inflammatory infiltrate, epithelial thickness, number of goblet cells, diameter and number of blood vessels. At the 8th and 30th posttreatment days, all groups, except one that received artificial tears, exhibited a diffuse inflammatory infiltrate, composed by lymphocytes and neutrophils, which was denser in the timolol group than in the prostaglandin (PG) analogues groups. At the 30th day, the timolol group also showed an increased subepithelial collagen density and a significant increase in epithelial thickness (p=0.0035). The goblet cell density was significantly increased at the 8th day in the group treated with travoprost (p=0.0006), and at the 30th day in those treated with bimatoprost (p=0.0021) and latanoprost (p=0.009). Although a moderate, diffuse inflammatory infiltrate was observed in PG-treated eyes, no changes in conjunctival epithelial thickness or subconjunctival collagen density were observed with these medications, suggesting that these drugs induce fewer changes than timolol maleate in the rabbit conjunctiva. |
Author | Costa, Vital Paulino Truppel, Jessé Henrique Strobel, Eduardo von Linsingen Correa Neto, Mario Adolfo Russ, Heloisa Helena Abil Valgas, Sílvia Regina Ferreira, Fabiano Montiani |
AuthorAffiliation | Universidade Federal do Paraná Universidade de São Paulo Hospital Universitário Evangélico de Curitiba |
AuthorAffiliation_xml | – name: Universidade de São Paulo – name: Hospital Universitário Evangélico de Curitiba – name: Universidade Federal do Paraná |
Author_xml | – sequence: 1 givenname: Heloisa Helena Abil surname: Russ fullname: Russ, Heloisa Helena Abil email: heloisaruss@onda.com.br organization: Universidade de São Paulo, São Paulo, SP, Brazil. heloisaruss@onda.com.br – sequence: 2 givenname: Vital Paulino surname: Costa fullname: Costa, Vital Paulino – sequence: 3 givenname: Fabiano Montiani surname: Ferreira fullname: Ferreira, Fabiano Montiani – sequence: 4 givenname: Sílvia Regina surname: Valgas fullname: Valgas, Sílvia Regina – sequence: 5 givenname: Mario Adolfo surname: Correa Neto fullname: Correa Neto, Mario Adolfo – sequence: 6 givenname: Eduardo von Linsingen surname: Strobel fullname: Strobel, Eduardo von Linsingen – sequence: 7 givenname: Jessé Henrique surname: Truppel fullname: Truppel, Jessé Henrique |
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DocumentTitleAlternate | Alterações conjuntivais induzidas por análogos de prostaglandinas e maleato de timolol: estudo histomorfométrico |
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Keywords | Glaucoma synthetic Rabbits Prostaglandins Conjuntiva Coelhos Conjunctiva Prostaglandinas sintéticas Timolol |
Language | English Portuguese |
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Snippet | To compare histological changes induced by antiglaucoma medications in the rabbit conjunctiva.
Fifty New Zealand rabbits were divided in 5 groups of 10... PURPOSE: To compare histological changes induced by antiglaucoma medications in the rabbit conjunctiva. METHODS: Fifty New Zealand rabbits were divided in 5... |
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SubjectTerms | Amides - administration & dosage Amides - adverse effects Analysis of Variance Animals Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Benzalkonium Compounds - administration & dosage Benzalkonium Compounds - adverse effects Bimatoprost Biopsy Cloprostenol - administration & dosage Cloprostenol - adverse effects Cloprostenol - analogs & derivatives Conjunctiva - drug effects Conjunctiva - pathology Disease Models, Animal Female Goblet Cells - drug effects Goblet Cells - pathology Ophthalmic Solutions - administration & dosage OPHTHALMOLOGY Prostaglandins F, Synthetic - administration & dosage Prostaglandins F, Synthetic - adverse effects Prostaglandins, Synthetic - administration & dosage Prostaglandins, Synthetic - adverse effects Rabbits Staining and Labeling Time Factors Timolol - administration & dosage Timolol - adverse effects Travoprost |
Title | Conjunctival changes induced by prostaglandin analogues and timolol maleate: a histomorphometric study |
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