Long-term exposure to low-dose Haemophilus influenzae during allergic airway disease drives a steroid-resistant neutrophilic inflammation and promotes airway remodeling

• Published in: Oncotarget Vol. 9; no. 38; pp. 24898 - 24913
• Main Authors: Yang, Xu, Wang, Yijie, Zhao, Shengtao, Wang, Ran, Wang, Changzheng
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 18.05.2018
• Subjects: Research Paper: Immunology; allergic airway disease; long-term effect; neutrophilic inflammation; Immunology; Haemophilus influenzae; airway remodeling

Growing evidences indicate that bacteria are associated with pathogenesis of neutrophilic asthma. However, the long-term effect of airway bacterial colonization remains unclear. We sought to establish a murine model to simulate the airway inflammation of long-term bacterial colonization, and to asse...