GSTM1 , GSTT1 , and GSTP1 polymorphisms and colorectal cancer risk in Polish nonsmokers

• Published in: Oncotarget Vol. 9; no. 30; pp. 21224 - 21230
• Main Authors: Klusek, Justyna, Nasierowska-Guttmejer, Anna, Kowalik, Artur, Wawrzycka, Iwona, Lewitowicz, Piotr, Chrapek, Magdalena, Głuszek, Stanisław
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 20.04.2018
• Subjects: Research Paper; gene polymorphism; GSTT1; GSTM1; colorectal cancer; GSTP1
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.25031

Glutathione S-transferase (GST) enzymes are responsible for cellular detoxification of many carcinogens and are important anticancer elements. This study assessed potential relationships between , , and polymorphisms and colorectal cancer (CRC) risk in Polish nonsmokers. We also analyzed the influence of gene polymorphisms on CRC clinical and histopathological features. Our study included 197 CRC patients and 104 healthy controls. , , and polymorphisms were evaluated using qPCR. Polymorphism frequencies observed in our control group corresponded to those in other European populations. The and genotypes were observed with similar frequencies in both CRC patients and controls ( : 46.7% vs. 45.2%; : 15.7% vs. 20.2%). , , and genotype frequencies were respectively 42.1%, 48.2%, and 9.6% in patients and 48.1%, 42.3%, and 9.6% in controls. polymorphism correlated with higher tumor grade in CRC patients, and the genotype was associated with more frequent metastasis to lymph nodes (pN classification). Our results suggest that gene polymorphisms may influence CRC tumor grade and stage.