High glucose induces FABP3-mediated membrane rigidity via downregulation of SIRT1

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 6; p. 130802
• Main Authors: Lee, Seung-Min, Kwak, Ju Yeon, Ryu, Dongryeol, Shin, Yeo Jin, Lee, Younglang, Yang, Yong Ryoul, Lee, Kwang-Pyo, Suh, Jae Myoung, Kwon, Ki-Sun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2025
• Subjects: Animals; Cell Membrane - metabolism; Down-Regulation; FABP3; Fatty Acid Binding Protein 3 - genetics; Fatty Acid Binding Protein 3 - metabolism; Glucose - metabolism; Glucose - pharmacology; High glucose; Hyperglycemia; Hyperglycemia - genetics; Hyperglycemia - metabolism; Male; Membrane Fluidity; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal - metabolism; Muscle, Skeletal - metabolism; NAD+-SIRT1; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; PUFA; GP; SCD-1; SREBP-1c; PPARγ; SFA; Membrane fluidity; FABP3; Hyperglycemia; ChREBP; LPAAT3; FRAP; NAD+-SIRT1; BODIPY 500/510 C1 C12; High glucose; NAD(+)-SIRT1

High glucose induces an atypical lipid composition in skeletal muscle, leading to loss of muscle mass and strength. However, the mechanisms underlying this glucose toxicity are not fully understood. Analysis of genes associated with a phenotype using the BXD phenome resource revealed that increased...