MYO9B deficiency promoted head and neck tumor progression through HIF1α/MYC/STAT2 signaling pathway

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 9; p. 130834
• Main Authors: Gao, Simin, Gao, Xia, Wang, Ning, Xie, Yuping, Tang, Yuedi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2025
• Subjects: c-Myc; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; HIF1α; HNSC; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Male; MYO9B; Myosins - deficiency; Myosins - genetics; Myosins - metabolism; Prognosis; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Signal Transduction; Squamous Cell Carcinoma of Head and Neck - genetics; Squamous Cell Carcinoma of Head and Neck - metabolism; Squamous Cell Carcinoma of Head and Neck - pathology; STAT2; MYO9B; c-Myc; HIF1α; STAT2; HNSC

Myosin, a protein family primarily involved in muscle contraction and cell movement, plays critical roles in various biological processes. Increasing evidence suggests its implication in tumor development and progression. However, the underlying mechanism remains poorly understood. Our study aimed t...