Label-free detection of high-risk human papillomaviruses infection using Raman spectroscopy and multivariate analysis

• Published in: Laser physics letters Vol. 17; no. 11; pp. 115601 - 115609
• Main Authors: Zheng, Xiangxiang, Wang, Jing, Yin, Longfei, Luo, Bin, Lv, Xiaoyi, Wu, Guohua
• Format: Journal Article
• Language: English
• Published: IOP Publishing 01.11.2020
• Subjects: cervical exfoliated cell specimens; high-risk human papillomaviruses; linear discriminant analysis; principal component analysis; Raman spectroscopy

Persistent infection with high-risk human papillomavirus (HR-HPV) is considered as the leading cause of pre-cervical cancer and cancer. Currently, HPV testing is expensive, time-consuming, and requires experienced technicians. Here, we report a method for label-free detection of HR-HPV by recording...