Microwave-induced Apoptosis and Cytotoxicity of NK Cells through ERK1/2 Signaling

• Published in: Biomedical and environmental sciences Vol. 30; no. 5; pp. 323 - 332
• Main Authors: ZHAO, Li, LI, Jing, HAO, Yan Hui, GAO, Ya Bing, WANG, Shui Ming, ZHANG, Jing, DONG, Ji, ZHOU, Hong Mei, LIU, Shu Chen, PENG, Rui Yun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2017; Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing 100850, China%Department of Pathology, General Hospital of Beijing Command of PLA, Beijing 100700, China
• Subjects: Apoptosis; Apoptosis - radiation effects; Cell cycle; Cell Cycle - radiation effects; Cell Line; Cytotoxicity; Dose-Response Relationship, Radiation; Down-Regulation; Humans; Killer Cells, Natural - radiation effects; MAP Kinase Signaling System; Microwave; Microwaves - adverse effects; Natural killer cells; NK Cell Lectin-Like Receptor Subfamily K - genetics; NK Cell Lectin-Like Receptor Subfamily K - metabolism; Perforin; Signal Transduction; Microwave; Cytotoxicity; Natural killer cells; Perforin; Cell cycle; Apoptosis

Objective To investigate microwave-induced morphological and functional injury of natural killer（NK） cells and uncover their mechanisms. Methods NK-92 cells were exposed to 10, 30, and 50 m W/cm~2 microwaves for 5 min. Ultrastructural changes, cellular apoptosis and cell cycle regulation were detect...