Design and synthesis of guaianolide‐germacranolide heterodimers as novel anticancer agents against hepatocellular carcinoma

• Published in: Drug development research Vol. 84; no. 6; pp. 1285 - 1298
• Main Authors: Yan, Jia‐Xin, Li, Qi‐Hao, Li, Tian‐Ze, Huang, Zhi‐Yan, Ma, Yun‐Bao, Chen, Ji‐Jun
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2023
• Subjects: Anticancer properties; Antitumor agents; Apoptosis; Biomimetics; Cell migration; Cytotoxicity; Diels-Alder reactions; Functional groups; Hepatocellular carcinoma; Hepatoma; Monomers; Natural products; Pharmacology; Surface plasmon resonance; Synthesis; Toxicity; Urea; antihepatoma effects; PDGFRA; guaianolide-germacranolide heterodimers
• ISSN: 0272-4391; 1098-2299; 1098-2299
• DOI: 10.1002/ddr.22087

Inspired by our previous finding that disesquiterpenoids showed more potent antihepatoma cytotoxicity than their corresponding parent monomers, natural product‐like guaianolide‐germacranolide heterodimers were designed and synthesized from guaianolide diene and germacranolides via a biomimetic Diels...