An integrative analysis reveals mechanisms of Prunella vulgaris in thyroid cancer metastasis

• Published in: Phytomedicine (Stuttgart) Vol. 145; p. 157051
• Main Authors: Zeng, Shifan, Liu, Benjuan, Ge, Rui, Yuan, Zhilong, Yang, Yunyun, Zhu, Weiqiang, Wang, Zhuo
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.09.2025
• Subjects: Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; Cell Movement - drug effects; Cell Proliferation - drug effects; Cell Survival - drug effects; Gene Expression Regulation, Neoplastic - drug effects; Humans; Lymph nodes metastasis; Lymphatic Metastasis; Membrane Potential, Mitochondrial - drug effects; Network pharmacology; Papillary thyroid carcinoma; Prunella - chemistry; Prunella vulgaris; Reactive Oxygen Species - metabolism; Sitosterols - pharmacology; Thyroid Cancer, Papillary - drug therapy; Thyroid Cancer, Papillary - genetics; Thyroid Cancer, Papillary - pathology; Thyroid Neoplasms - drug therapy; Thyroid Neoplasms - genetics; Thyroid Neoplasms - pathology; Β-sitosterol; Lymph nodes metastasis; DL; PPI; LNM; ADRB2; SD; BS; OB; KEGG; CCK-8; Network pharmacology; TCMSP; DEG; GO; EMT; ECM; MMP; ROS; Prunella vulgaris; Β-sitosterol; CTI; RAI; Papillary thyroid carcinoma; PTC; TCM

Lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) is a major contributor to poor prognosis. Prunella vulgaris (P. vulgaris), a traditional medicinal herb, has shown potential in inhibiting PTC metastasis, but its molecular mechanism remains unclear. This study aimed to elucidate the m...