Evolution of 8-esterified cycloberberines as a novel class of antibacterial agents against MDR gram-positive strains by targeting DNA polymerase IIIC - Fan, Tianyun; Zhao, Liping; Ma, Xican; Tang, Jia; Duan, Qionglu; Zhu, Xi; Liu, Yonghua; Jiang, Jiandong; Li, Yinghong; Song, Danqing (Bioorganic chemistry, 2025)
Keywords: Animals; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Berberine - analogs & derivatives; Berberine - chemical synthesis; Berberine - chemistry; Berberine - pharmacology; Cycloberberine ester; DNA polymerase IIIC; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial - drug effects; Gram-Positive Bacteria - drug effects; Humans; Interleukins - chemistry; Methicillin-Resistant Staphylococcus aureus - drug effects; Mice; Microbial Sensitivity Tests; Molecular Structure; MRSA; Structure-Activity Relationship; Antibacterial activity; Cycloberberine ester; DNA polymerase IIIC; Structure-activity relationship; MRSA