The role of tumor-associated fibroblast-derived exosomes in chemotherapy resistance of colorectal cancer and its application prospect

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 6; p. 130796
• Main Authors: Liu, Meichen, Li, Teng-zheng, Xu, Congcong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2025
• Subjects: Antineoplastic Agents - therapeutic use; Biomarkers; CAFs; Cancer-Associated Fibroblasts - metabolism; Cancer-Associated Fibroblasts - pathology; Chemoresistance; Colorectal cancer; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Exosomes; Exosomes - metabolism; Exosomes - pathology; Humans; Transforming Growth Factor beta1 - metabolism; Tumor microenvironment; Wnt Signaling Pathway; Biomarkers; CAFs; Tumor microenvironment; Exosomes; Colorectal cancer; Chemoresistance

Colorectal cancer (CRC) is the second most common malignant tumor in the world. With its increasing incidence and younger age trend, its impact on human health has been paid more and more attention. Currently, we have a variety of chemotherapy drugs that can be used to treat colorectal cancer. Howev...