On a subdiffusive tumour growth model with fractional time derivative

Abstract In this work, we present and analyse a system of coupled partial differential equations, which models tumour growth under the influence of subdiffusion, mechanical effects, nutrient supply and chemotherapy. The subdiffusion of the system is modelled by a time fractional derivative in the eq...

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Bibliographic Details
Published inIMA journal of applied mathematics Vol. 86; no. 4; pp. 688 - 729
Main Authors Fritz, Marvin, Kuttler, Christina, Rajendran, Mabel L, Wohlmuth, Barbara, Scarabosio, Laura
Format Journal Article
LanguageEnglish
Published Oxford University Press 01.08.2021
Subjects
mechanical deformation
subdiffusive tumour growth
nonlinear partial differential equation
well posedness
fractional time derivative
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Summary:Abstract In this work, we present and analyse a system of coupled partial differential equations, which models tumour growth under the influence of subdiffusion, mechanical effects, nutrient supply and chemotherapy. The subdiffusion of the system is modelled by a time fractional derivative in the equation governing the volume fraction of the tumour cells. The mass densities of the nutrients and the chemotherapeutic agents are modelled by reaction diffusion equations. We prove the existence and uniqueness of a weak solution to the model via the Faedo–Galerkin method and the application of appropriate compactness theorems. Lastly, we propose a fully discretized system and illustrate the effects of the fractional derivative and the influence of the fractional parameter in numerical examples.
ISSN:0272-4960
1464-3634
DOI:10.1093/imamat/hxab009