Pantoprazole reduces the size of postbanding ulcers after variceal band ligation A randomized, controlled trial

• Published in: Hepatology (Baltimore, Md.) Vol. 41; no. 3; pp. 588 - 594
• Main Authors: Shaheen, Nicholas J., Stuart, Eugene, Schmitz, Sarah M., Mitchell, Kate L., Fried, Michael W., Zacks, Steven, Russo, Mark W., Galanko, Joseph, Shrestha, Roshan
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Wiley 01.03.2005
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles; Benzimidazoles - therapeutic use; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Double-Blind Method; Esophageal and Gastric Varices - complications; Esophageal and Gastric Varices - surgery; Esophagus; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal Hemorrhage - prevention & control; Humans; Ligation - adverse effects; Liver. Bile. Biliary tracts; Male; Medical sciences; Middle Aged; Omeprazole - analogs & derivatives; Omeprazole - therapeutic use; Other diseases. Semiology; Sulfoxides - therapeutic use; Ulcer - prevention & control; Vertebrates: digestive system; Esophagogastroduodenoscopy; Prognosis; Intravenous administration; Toxicity; Size; Esophageal disease; H; Check; Cardiovascular disease; Antiulcer agent; K; Hemorrhage; Venous disease; Proton pump inhibitor; Prevention; Vascular disease; Pain; Antisecretory agent; Secondary effect; Proton; Ulcer; Dysphagia; Varix; Human; Stomach; Surgical cerclage; Pantoprazole; Enzyme; Oral administration; Enzyme inhibitor; Thorax; Bacteremia; Infection; Benzimidazole derivatives; Risk factor; Bacteriosis; Digestive diseases; exchanging ATPase; Hydrolases; Arm

Elective esophageal variceal ligation (EVL) is performed to decrease the risk of variceal hemorrhage. Side effects of EVL include hemorrhage, chest pain, dysphagia, and odynophagia. Because gastric acid may exacerbate postbanding ulcers and delay healing, proton pump inhibition may decrease side eff...