Genetic diversity of TLR2, TLR4, and VDR loci and pulmonary tuberculosis in Moroccan patients

• Published in: Journal of infection in developing countries Vol. 8; no. 4; pp. 430 - 440
• Main Authors: Arji, Naima, Busson, Marc, Iraqi, Ghali, Bourkadi, Jamal Eddine, Benjouad, Abdelaziz, Bouayad, Abdellatif, Mariaselvam, Christina, Salah, Sofiane, Fortier, Catherine, Amokrane, Kahina, Marzais, François, Boukouaci, Wahid, Krishnamoorthy, Rajagopal, Charron, Dominique, El Aouad, Rajae, Tamouza, Ryad
• Format: Journal Article
• Language: English
• Published: Italy Journal of Infection in Developing Countries 15.04.2014
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Genetic Predisposition to Disease; Haplotypes; Humans; Male; Middle Aged; Morocco; Polymorphism, Single Nucleotide; Receptors, Calcitriol - genetics; Toll-Like Receptor 2 - genetics; Toll-Like Receptor 4 - genetics; Tuberculosis; Tuberculosis, Pulmonary - genetics; Young Adult; Morocco

Toll-like receptors (TLRs) 2, 4, and the vitamin D receptor (VDR) are central components of the innate and adaptive immunity against Mycobacterium tuberculosis (Mtb). TLR2, TLR4, and VDR polymorphisms were previously associated with tuberculosis (TB) and were here investigated as candidates for pulm...