Characteristics and long-term outcome in a large series of chronic myelomonocytic leukaemia patients including 104 formerly referred to as oligomonocytic

• Published in: British journal of haematology Vol. 204; no. 3; pp. 892 - 897
• Main Authors: Castaño-Díez, Sandra, Pomares, Helena, Esteban, Daniel, Guijarro, Francesca, Jiménez-Vicente, Carlos, Zugasti, Inés, Álamo, José Ramón, Mayayo, Víctor Torrecillas, López-Guerra, Mònica, de la Fuente, Cristina, Charry, Paola, Cortés-Bullich, Albert, Bataller, Álex, Maluquer, Clara, Colomer, Dolors, Rozman, María, Arnan, Montserrat, Xicoy, Blanca, Esteve, Jordi, Díaz-Beyá, Marina
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.03.2024
• Subjects: Chronic myelomonocytic leukemia; Humans; Leukemia, Myelomonocytic, Chronic - diagnosis; Leukocytosis; Monocytosis; Multivariate analysis; Prognosis; chronic myelomonocytic leukaemia; CMML; oligomonocytic
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1111/bjh.19217

Recently modified diagnostic criteria for chronic myelomonocytic leukaemia (CMML) have lowered the cut-off for absolute monocytosis. In the largest series to date, we have analysed 313 CMML patients, including 104 with oligomonocytic (OM)-CMML. Five-year survival was longer for OM-CMML than for other patients (p < 0.001). Multivariate analysis identified OM-CMML as a favourable prognostic factor (HR 0.58; p = 0.002). The 5-year cumulative incidence of progression to classical CMML was 47%. Older age and transfusion dependence were adverse prognostic factors for OM-CMML. Our results support the inclusion of OM-CMML in the CMML category as a subtype with superior outcomes.