Involvement of the kynurenine pathway in the pathogenesis of Parkinson's disease
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of dopaminergic neurons and localized neuroinflammation occurring in the midbrain several years before the actual onset of symptoms. Neuroinflammation leads to microglia activation and release of a large numbe...
Saved in:
| Published in | Progress in neurobiology Vol. 155; pp. 76 - 95 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.08.2017
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of dopaminergic neurons and localized neuroinflammation occurring in the midbrain several years before the actual onset of symptoms. Neuroinflammation leads to microglia activation and release of a large number of proinflammatory mediators. The kynurenine pathway (KP) of tryptophan catabolism is one of the major regulators of the immune response and is also likely to be implicated in the inflammatory and neurotoxic events in Parkinsonism. Several neuroactive compounds are produced through the KP that can be either a neurotoxic, neuroprotective or immunomodulator. Among these metabolites kynurenic acid (KYNA), produced by astrocytes, is considered as neuroprotective whereas quinolinic acid (QUIN), released by activated microglia, can activate the N-methyl-d-aspartate (NMDA) receptor-signalling pathway, leading to excitotoxicity and amplify the inflammatory response. Previous studies have shown that NMDA antagonists can ease symptoms and exert a neuroprotective effect in PD both in vivo and in vitro. There are to date several lines of evidence linking some of the KP intermediates and the neuropathogenesis of PD. Moreover, it is likely that some of the KP metabolites could be used as prognostic biomarkers and that pharmacological modulators of the KP enzymes could represent a new therapeutic strategy for PD. |
|---|---|
| AbstractList | Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of dopaminergic neurons and localized neuroinflammation occurring in the midbrain several years before the actual onset of symptoms. Neuroinflammation leads to microglia activation and release of a large number of proinflammatory mediators. The kynurenine pathway (KP) of tryptophan catabolism is one of the major regulators of the immune response and is also likely to be implicated in the inflammatory and neurotoxic events in Parkinsonism. Several neuroactive compounds are produced through the KP that can be either a neurotoxic, neuroprotective or immunomodulator. Among these metabolites kynurenic acid (KYNA), produced by astrocytes, is considered as neuroprotective whereas quinolinic acid (QUIN), released by activated microglia, can activate the N-methyl-d-aspartate (NMDA) receptor-signalling pathway, leading to excitotoxicity and amplify the inflammatory response. Previous studies have shown that NMDA antagonists can ease symptoms and exert a neuroprotective effect in PD both in vivo and in vitro. There are to date several lines of evidence linking some of the KP intermediates and the neuropathogenesis of PD. Moreover, it is likely that some of the KP metabolites could be used as prognostic biomarkers and that pharmacological modulators of the KP enzymes could represent a new therapeutic strategy for PD. |
| Author | Herrero, Maria Trinidad Lim, Chai K Fernandez-Villalba, Emiliano Zinger, Anna Bessede, Alban Fernández-Gomez, Francisco J Braidy, Nady Costa, Cristina Costa, Silvia Estrada, Cristina Guillemin, Gilles J |
| Author_xml | – sequence: 1 givenname: Chai K surname: Lim fullname: Lim, Chai K organization: Neuroinflammation Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia – sequence: 2 givenname: Francisco J surname: Fernández-Gomez fullname: Fernández-Gomez, Francisco J organization: Clinical & Experimental Neuroscience, Institute of Biomedical Research of Murcia (IMIB), Institute of Aging Research, School of Medicine, University of Murcia, 30100 Murcia, Spain – sequence: 3 givenname: Nady surname: Braidy fullname: Braidy, Nady organization: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia – sequence: 4 givenname: Cristina surname: Estrada fullname: Estrada, Cristina organization: Clinical & Experimental Neuroscience, Institute of Biomedical Research of Murcia (IMIB), Institute of Aging Research, School of Medicine, University of Murcia, 30100 Murcia, Spain – sequence: 5 givenname: Cristina surname: Costa fullname: Costa, Cristina organization: Clinical & Experimental Neuroscience, Institute of Biomedical Research of Murcia (IMIB), Institute of Aging Research, School of Medicine, University of Murcia, 30100 Murcia, Spain; Laboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil – sequence: 6 givenname: Silvia surname: Costa fullname: Costa, Silvia organization: Laboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil – sequence: 7 givenname: Alban surname: Bessede fullname: Bessede, Alban organization: ImmuSmol, Pessac, France – sequence: 8 givenname: Emiliano surname: Fernandez-Villalba fullname: Fernandez-Villalba, Emiliano organization: Clinical & Experimental Neuroscience, Institute of Biomedical Research of Murcia (IMIB), Institute of Aging Research, School of Medicine, University of Murcia, 30100 Murcia, Spain – sequence: 9 givenname: Anna surname: Zinger fullname: Zinger, Anna organization: Vascular Immunology Unit, Dept of Pathology, Sydney Medical School, The University of Sydney, Australia – sequence: 10 givenname: Maria Trinidad surname: Herrero fullname: Herrero, Maria Trinidad email: mtherrer@um.es organization: Clinical & Experimental Neuroscience, Institute of Biomedical Research of Murcia (IMIB), Institute of Aging Research, School of Medicine, University of Murcia, 30100 Murcia, Spain. Electronic address: mtherrer@um.es – sequence: 11 givenname: Gilles J surname: Guillemin fullname: Guillemin, Gilles J email: gilles.guillemin@mq.edu.au organization: Neuroinflammation Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia; Applied Neurosciences Program, Peter Duncan Neurosciences Research Unit, St Vincent's Centre for Applied Medical Research, Sydney, Australia. Electronic address: gilles.guillemin@mq.edu.au |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27072742$$D View this record in MEDLINE/PubMed |
| BookMark | eNo9kMtOwzAQRS1UREvhFyA7VgkzduzES1TxqFSJLrq33GRC04cdxW1R_56EQlejq7lnpDm3bOC8I8YeERIEVM_rpHF0aP2y9gkHlAnyBEBfsRHmmYglYj5gIxCAMUDOh-w2hDUAKAHihg15BhnPUj5i86k7-u2RduT2ka-i_YqizckdWnK1o6ix-9W3PUW1-9300X-Ro1CHvj237aZ2wbunEJV1IBvojl1Xdhvo_m-O2eLtdTH5iGef79PJyywuBIp9rPKCsJKp1qLSkgSoUktuSXGd6yIVssg4KsnRIuiCd_-USqSqSzLPyYoxy85ni9aH0FJlmrbe2fZkEEyvyKzNRZHpFRnkplPUkQ9nsjksd1ReuH8n4gcMr2dL |
| CitedBy_id | crossref_primary_10_3389_fped_2020_613749 crossref_primary_10_1007_s12035_023_03815_9 crossref_primary_10_1016_j_bioelechem_2020_107534 crossref_primary_10_1016_j_cbi_2019_108884 crossref_primary_10_3390_ijms22062973 crossref_primary_10_1016_j_arr_2020_101204 crossref_primary_10_1093_infdis_jiz048 crossref_primary_10_1089_photob_2021_0066 crossref_primary_10_3389_fimmu_2022_997240 crossref_primary_10_3389_fimmu_2021_702301 crossref_primary_10_1016_j_jneuroim_2019_577088 crossref_primary_10_1159_000515066 crossref_primary_10_3390_ijms22136737 crossref_primary_10_1089_photob_2019_4628 crossref_primary_10_1371_journal_pone_0252668 crossref_primary_10_1007_s12035_021_02375_0 crossref_primary_10_1111_febs_15721 crossref_primary_10_3389_fimmu_2022_985378 crossref_primary_10_3389_fnagi_2017_00214 crossref_primary_10_3389_fmolb_2019_00003 crossref_primary_10_1111_jnc_14843 crossref_primary_10_3390_ijms22010403 crossref_primary_10_3390_genes13122397 crossref_primary_10_1016_j_intimp_2023_109840 crossref_primary_10_1007_s11306_019_1605_3 crossref_primary_10_1016_j_exger_2020_110841 crossref_primary_10_1016_j_snb_2019_127532 crossref_primary_10_3389_fncel_2021_638854 crossref_primary_10_1016_j_abb_2020_108702 crossref_primary_10_1177_1178646920978404 crossref_primary_10_1039_D3AY01959D crossref_primary_10_3390_molecules24203709 crossref_primary_10_3389_fpsyt_2021_791991 crossref_primary_10_1016_j_mrrev_2018_03_001 crossref_primary_10_3389_fneur_2022_844841 crossref_primary_10_1152_ajprenal_00690_2016 crossref_primary_10_1021_acschemneuro_9b00265 crossref_primary_10_3390_biom12070998 crossref_primary_10_3390_ijms25031698 crossref_primary_10_3390_cells9071717 crossref_primary_10_3389_fmicb_2022_988643 crossref_primary_10_1007_s40495_019_00208_2 crossref_primary_10_1016_j_cmet_2023_06_004 crossref_primary_10_1016_j_biopsych_2021_05_021 crossref_primary_10_1021_acschemneuro_1c00259 crossref_primary_10_1016_j_neuroimage_2021_118842 crossref_primary_10_3390_ijms21176070 crossref_primary_10_9758_cpn_2020_18_4_507 crossref_primary_10_1007_s10072_020_04589_x crossref_primary_10_3390_ijms25020853 crossref_primary_10_3389_fnins_2023_1217451 crossref_primary_10_1172_JCI164577 crossref_primary_10_1038_s41380_019_0414_4 crossref_primary_10_1007_s00213_022_06263_w crossref_primary_10_3389_fimmu_2021_701550 crossref_primary_10_1080_10408398_2021_1934813 crossref_primary_10_1007_s11306_019_1554_x crossref_primary_10_1002_brb3_2226 crossref_primary_10_1007_s11033_023_08859_7 crossref_primary_10_3233_JPD_171240 crossref_primary_10_1007_s12640_019_0010_z crossref_primary_10_3389_fneur_2023_1210453 crossref_primary_10_1016_j_ensci_2020_100270 crossref_primary_10_1016_j_scitotenv_2023_162358 crossref_primary_10_3389_fimmu_2018_01363 crossref_primary_10_3390_nu15173839 crossref_primary_10_1016_j_arr_2021_101347 crossref_primary_10_1016_j_chemosphere_2020_126715 crossref_primary_10_1016_j_exger_2019_110793 crossref_primary_10_14336_AD_2022_0916 crossref_primary_10_3389_fneur_2019_00574 crossref_primary_10_1111_jnc_14104 crossref_primary_10_2174_1570159X21666221216162606 crossref_primary_10_1021_acs_chemrestox_8b00421 crossref_primary_10_1007_s12640_017_9848_0 crossref_primary_10_1186_s40168_023_01589_9 crossref_primary_10_1002_jcp_30876 crossref_primary_10_1016_j_ejphar_2024_176420 crossref_primary_10_1016_j_bbi_2022_07_011 crossref_primary_10_1194_jlr_M079251 crossref_primary_10_1039_C9MO00090A crossref_primary_10_1007_s10571_020_01027_6 crossref_primary_10_1016_j_bbi_2022_10_022 crossref_primary_10_1177_08919887211018268 crossref_primary_10_1016_j_heliyon_2024_e34113 crossref_primary_10_1007_s12031_022_02028_4 crossref_primary_10_1016_j_aanat_2017_01_002 crossref_primary_10_1016_j_bioorg_2023_106906 crossref_primary_10_1016_j_ejmech_2023_115258 crossref_primary_10_1007_s11481_020_09925_8 crossref_primary_10_1016_j_tips_2020_11_006 crossref_primary_10_1002_mds_28202 crossref_primary_10_1021_acs_analchem_8b04852 crossref_primary_10_1080_14756366_2023_2225800 crossref_primary_10_1016_j_msec_2020_111028 crossref_primary_10_3390_pathogens13050397 |
| Cites_doi | 10.2174/1381612821666150710144502 10.1016/j.expneurol.2010.03.009 10.1002/mds.25945 10.1007/s007020200014 10.1371/journal.pone.0014123 10.1016/j.taap.2011.08.021 10.1371/journal.pgen.1002548 10.1016/j.jpba.2011.02.014 10.1038/srep00809 10.1007/s12640-009-9051-z 10.1016/S0967-5868(97)90076-X 10.1097/NEN.0b013e31829768d2 10.1016/j.ntt.2010.10.002 10.1002/glia.10175 10.1021/bi992997s 10.1016/j.neulet.2014.02.027 10.4137/IJTR.S2318 10.1016/S0006-8993(01)02017-0 10.1016/S0306-4522(96)00655-0 10.1111/febs.12401 10.1179/135100002125000550 10.2174/138161211795049552 10.1007/s00702-011-0676-8 10.1007/BF01101711 10.1074/jbc.M109.024042 10.1074/jbc.M512203200 10.1016/j.expneurol.2013.01.024 10.1016/0306-3623(93)90155-Q 10.1016/j.neuropharm.2012.03.009 10.1179/1351000212Y.0000000001 10.1111/j.1471-4159.1991.tb03460.x 10.1002/mds.25555 10.1097/00001756-200002070-00005 10.1016/j.taap.2013.01.025 10.1046/j.1471-4159.2001.00498.x 10.1006/exnr.2000.7535 10.1038/cddis.2011.17 10.1007/s00401-006-0086-4 10.1016/j.jprot.2012.02.032 10.1016/S0165-6147(00)01451-6 10.1038/sj.bjp.0702940 10.2174/1871527313666140711091400 10.1016/0006-8993(90)90826-W 10.1007/BF03033908 10.4049/jimmunol.171.4.1652 10.1016/j.bbadis.2014.11.019 10.1016/j.neuint.2013.01.029 10.1007/978-1-4615-0135-0_12 10.1002/jnr.21799 10.1002/mds.25844 10.1111/j.1471-4159.2006.04199.x 10.1124/mol.111.074765 10.1046/j.1471-4159.1999.0730750.x 10.1182/blood-2006-11-056010 10.1016/j.bbadis.2009.08.013 10.1159/000089622 10.1038/nrn752 10.1038/nrd870 10.1002/glia.20015 10.1186/1742-2094-2-16 10.1523/JNEUROSCI.21-19-07463.2001 10.1016/S0165-0270(97)00168-4 10.4161/auto.27191 10.1165/ajrcmb/6.6.639 10.1097/00001756-200108280-00020 10.1007/s12031-008-9137-8 10.1074/jbc.M114.624767 10.1016/j.mito.2013.08.006 10.1002/(SICI)1098-2396(20000615)36:4<267::AID-SYN3>3.0.CO;2-Y 10.1016/j.ics.2007.07.012 10.4049/jimmunol.1203121 10.1371/journal.pone.0027109 10.1016/0014-4886(84)90197-3 10.1038/nature12039 10.1016/j.pharmthera.2011.01.014 10.1586/ern.11.73 10.1007/s12640-009-9129-7 10.1016/j.ejcb.2008.03.003 10.1093/brain/awv297 10.1038/ng.3043 10.1016/0006-8993(89)90216-3 10.1016/0022-510X(94)00280-2 10.1016/j.ejphar.2011.05.069 10.1016/S0304-3940(02)00735-8 10.1186/1742-2094-8-94 10.1016/S0278-5846(01)00237-8 10.1016/B978-0-12-801022-8.00007-6 10.1111/j.1365-2990.2005.00655.x 10.1016/j.neures.2008.04.009 10.1007/978-1-4613-0381-7_38 10.1089/jir.1997.17.589 10.1007/BF00966592 10.1212/WNL.47.1.219 10.1046/j.1460-9568.1999.00806.x 10.1016/S0197-0186(01)00133-4 10.1016/0022-510X(92)90191-M 10.1002/path.2682 10.1016/S0197-4580(02)00065-9 10.1016/j.ntt.2011.07.002 10.1016/S0306-4522(97)00421-1 10.1093/toxsci/kfq024 10.1016/j.nbd.2008.09.010 10.1016/j.neuroscience.2005.03.019 10.1007/s12640-009-9034-0 10.1016/j.neuropharm.2013.08.002 10.1016/0006-8993(93)90615-T 10.1371/journal.pone.0047387 10.1093/hmg/ddh134 10.1111/j.1365-2141.1985.tb07446.x 10.1007/s00429-014-0718-8 10.1016/S0889-1591(02)00006-5 10.1016/j.jns.2005.07.006 10.1080/135502801300069692 10.5607/en.2014.23.4.271 10.1016/0006-8993(82)91048-4 10.1093/toxsci/kfs218 10.1176/appi.neuropsych.11110324 10.1158/0008-5472.CAN-12-0549 10.4137/IJTR.S12626 10.1002/glia.20090 10.1186/s12974-014-0169-4 10.1371/journal.pone.0112945 10.1016/j.neuropharm.2010.10.022 10.1111/jnc.12226 10.1111/j.1471-4159.2008.05241.x 10.4137/IJTR.S4294 10.1016/j.toxlet.2014.01.039 10.1111/j.1471-4159.1990.tb03143.x 10.1006/exnr.1998.6767 10.1038/ncb2901 10.1038/npp.2014.194 10.1371/journal.pone.0072046 10.1016/j.neures.2004.01.011 10.1038/nrd3793 10.1212/01.WNL.0000143060.98164.1A 10.3389/fnana.2015.00032 10.1093/brain/119.5.1717 10.1155/2012/401264 10.1007/s00018-013-1352-y 10.1111/j.1471-4159.2010.07159.x 10.1074/jbc.M200666200 10.1016/0304-3940(83)90115-5 10.1007/978-1-4613-0381-7_22 10.1038/npp.2012.248 10.4049/jimmunol.0903670 10.1111/j.1742-4658.2012.08485.x 10.1016/j.pneurobio.2012.06.003 10.1111/nan.12221 10.1016/S0197-0186(97)90002-4 10.1007/s10048-007-0090-4 10.1016/j.mcn.2013.04.007 10.1038/nbt.1685 10.1046/j.1471-4159.2000.0752427.x 10.1016/j.ejphar.2008.02.052 10.1002/anie.201408776 10.1016/S0140-6736(14)61010-2 10.1007/BF03033781 10.1046/j.1471-4159.1997.69041629.x 10.2174/187152709789824606 10.1371/journal.pone.0006344 10.1002/jnr.21183 10.1212/WNL.42.9.1702 10.1016/S0014-2999(00)00024-8 10.1038/321168a0 10.1016/j.neurobiolaging.2014.07.028 10.2174/187152707783399229 10.1016/S0361-9230(00)00368-3 10.1016/j.bbr.2008.11.037 10.1002/mds.20596 10.1002/1521-4141(200108)31:8<2313::AID-IMMU2313>3.0.CO;2-S 10.2174/18715273113129990082 10.1016/j.jneuroim.2013.05.001 10.1016/S0014-2999(02)01851-4 10.1111/j.1471-4159.1993.tb07443.x 10.1007/s11011-014-9557-9 10.1016/j.neuroscience.2004.04.043 10.1080/10715760100300391 10.1016/0006-8993(94)01368-R 10.1046/j.1471-4159.2001.00335.x 10.1042/bj2510893 10.1038/cddis.2012.123 10.1001/archgenpsychiatry.2011.71 10.1016/0028-3908(83)90221-6 10.1046/j.1440-1711.2003.t01-1-01177.x 10.1006/exnr.2000.7542 10.3233/JPD-140491 10.1155/2013/104024 10.1016/j.bbadis.2008.08.001 10.1006/exnr.1996.6365 10.1111/j.1742-4658.2009.07487.x 10.1371/journal.pone.0115439 10.1016/0304-3940(93)90796-N 10.1038/sj.bjp.0704613 10.1016/S0304-3940(02)00392-0 10.1007/s12192-013-0426-y 10.3389/fnana.2014.00159 10.1016/j.tins.2003.08.009 10.1016/j.neurobiolaging.2013.08.015 10.2174/138161282035140911142118 10.1186/1742-2094-6-36 10.1038/nrn3039 10.1038/ncb3005 10.1093/brain/awv104 10.1016/j.bbi.2014.07.012 10.1007/s10072-015-2180-7 10.1038/npp.2013.71 10.1016/0024-3205(90)90376-3 10.1016/0306-4522(96)00034-6 10.1002/mds.25883 10.1016/0301-0082(88)90027-5 10.1523/JNEUROSCI.4101-07.2007 10.1046/j.1471-4159.2001.00057.x 10.1073/pnas.0900096106 10.1016/0014-4886(89)90170-2 10.1016/S0079-6123(08)61770-7 10.1038/nature13323 10.4137/IJTR.S16800 10.1002/mds.25150 10.1017/S1092852900016734 10.1016/j.neurobiolaging.2013.10.073 10.1016/j.nbd.2006.07.005 10.1016/0304-3940(84)90050-8 10.1016/j.arr.2014.01.004 10.1097/00001756-200103260-00049 10.1016/j.expneurol.2006.01.034 10.1016/0006-8993(89)90814-7 10.1007/s12035-013-8554-z 10.1016/0197-0186(95)00091-7 10.1111/j.1600-0404.2005.00442.x 10.1016/j.pbb.2011.09.002 10.4137/IJTR.S2097 10.1002/mds.23455 10.1016/j.neuro.2007.07.010 10.1007/s00702-011-0697-3 10.1007/s00702-011-0755-x 10.1016/j.neuropharm.2006.03.027 10.1371/journal.pone.0087877 10.1016/j.molmed.2003.11.003 10.3389/fncel.2014.00211 10.1038/srep00953 10.1002/ana.22588 10.1016/S0306-4522(96)00409-5 10.1007/s12035-013-8483-x 10.1523/JNEUROSCI.17-02-00765.1997 10.1016/j.neurobiolaging.2015.01.014 10.1111/j.1476-5381.2010.00882.x 10.1016/j.bbr.2007.08.007 10.1038/nrneurol.2012.242 10.1016/j.ics.2007.07.011 10.1186/s12974-014-0204-5 |
| ContentType | Journal Article |
| Copyright | Copyright © 2016 Elsevier Ltd. All rights reserved. |
| Copyright_xml | – notice: Copyright © 2016 Elsevier Ltd. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION |
| DOI | 10.1016/j.pneurobio.2015.12.009 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1873-5118 |
| EndPage | 95 |
| ExternalDocumentID | 10_1016_j_pneurobio_2015_12_009 27072742 |
| Genre | Journal Article Review |
| GroupedDBID | --- --K --M -~X .GJ .~1 0R~ 0SF 123 1B1 1CY 1RT 1~. 1~5 29P 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXKI AAXLA AAXUO ABCQJ ABFNM ABFRF ABJNI ABMAC ABXDB ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADIYS ADMUD ADVLN AEBSH AEFWE AEKER AENEX AFJKZ AFKWA AFTJW AFXIZ AGHFR AGUBO AGWIK AGYEJ AHHHB AIEXJ AIKHN AITUG AJOXV AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC C45 CGR CS3 CUY CVF DU5 EBS ECM EFJIC EIF EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMQ HVGLF HZ~ IHE J1W KOM L7B M2V M41 MO0 MOBAO N9A NPM O-L O9- OAUVE OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SNS SPCBC SSN SSZ T5K TEORI WUQ ZGI ZXP ~G- AAYXX CITATION |
| ID | FETCH-LOGICAL-c313t-68ce1f54993f95e306d952ae62989c435c7216521a109c2118d6346a10588ea3 |
| ISSN | 0301-0082 |
| IngestDate | Thu Sep 26 16:22:13 EDT 2024 Sat Sep 28 08:46:29 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Language | English |
| License | Copyright © 2016 Elsevier Ltd. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c313t-68ce1f54993f95e306d952ae62989c435c7216521a109c2118d6346a10588ea3 |
| PMID | 27072742 |
| PageCount | 20 |
| ParticipantIDs | crossref_primary_10_1016_j_pneurobio_2015_12_009 pubmed_primary_27072742 |
| PublicationCentury | 2000 |
| PublicationDate | 2017-Aug 2017-08-00 |
| PublicationDateYYYYMMDD | 2017-08-01 |
| PublicationDate_xml | – month: 08 year: 2017 text: 2017-Aug |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Progress in neurobiology |
| PublicationTitleAlternate | Prog Neurobiol |
| PublicationYear | 2017 |
| References | Lowe (10.1016/j.pneurobio.2015.12.009_bib0760) 2014; 9 Guillemin (10.1016/j.pneurobio.2015.12.009_bib0495) 2001; 78 Meyer (10.1016/j.pneurobio.2015.12.009_bib0820) 1992; 6 Lugo-Huitron (10.1016/j.pneurobio.2015.12.009_bib0780) 2013; 2013 Schildknecht (10.1016/j.pneurobio.2015.12.009_bib1115) 2013; 125 Gao (10.1016/j.pneurobio.2015.12.009_bib0400) 2013; 8 Fukuyama (10.1016/j.pneurobio.2015.12.009_bib0390) 2014; 76 Owe-Young (10.1016/j.pneurobio.2015.12.009_bib0930) 2008; 105 Schurr (10.1016/j.pneurobio.2015.12.009_bib1120) 1993; 617 Beal (10.1016/j.pneurobio.2015.12.009_bib0105) 1990; 55 Braidy (10.1016/j.pneurobio.2015.12.009_bib0175) 2010; 277 Prajapati (10.1016/j.pneurobio.2015.12.009_bib1010) 2015; 1852 Licker (10.1016/j.pneurobio.2015.12.009_bib0735) 2012; 75 Niranjan (10.1016/j.pneurobio.2015.12.009_bib0910) 2014; 49 Guillemin (10.1016/j.pneurobio.2015.12.009_bib0480) 2002; 7 Knyihar-Csillik (10.1016/j.pneurobio.2015.12.009_bib0685) 2006; 112 Hilmas (10.1016/j.pneurobio.2015.12.009_bib0605) 2001; 21 Lu (10.1016/j.pneurobio.2015.12.009_bib0765) 2014; 35 Steiner (10.1016/j.pneurobio.2015.12.009_bib1175) 2011 Zhu (10.1016/j.pneurobio.2015.12.009_bib1375) 1989; 481 Gratwicke (10.1016/j.pneurobio.2015.12.009_bib0460) 2015; 138 Gonzalez (10.1016/j.pneurobio.2015.12.009_bib0445) 2013; 190 Guillemin (10.1016/j.pneurobio.2015.12.009_bib0515) 2005; 31 Perkins (10.1016/j.pneurobio.2015.12.009_bib0960) 1982; 247 Ceresoli-Borroni (10.1016/j.pneurobio.2015.12.009_bib0225) 2007; 85 Santamaria (10.1016/j.pneurobio.2015.12.009_bib1095) 2001; 12 Hyun (10.1016/j.pneurobio.2015.12.009_bib0615) 2002; 277 McGeer (10.1016/j.pneurobio.2015.12.009_bib0795) 1984; 86 Mostafalou (10.1016/j.pneurobio.2015.12.009_bib0855) 2013; 268 McNally (10.1016/j.pneurobio.2015.12.009_bib0800) 2008; 13 Lim (10.1016/j.pneurobio.2015.12.009_bib0745) 2007; 1304 Zecca (10.1016/j.pneurobio.2015.12.009_bib1370) 2003; 26 de Carvalho (10.1016/j.pneurobio.2015.12.009_bib0285) 1996; 28 Guillemin (10.1016/j.pneurobio.2015.12.009_bib0485) 2002; 7 Guridi (10.1016/j.pneurobio.2015.12.009_bib0555) 1996; 119 Jauch (10.1016/j.pneurobio.2015.12.009_bib0635) 1995; 130 Annese (10.1016/j.pneurobio.2015.12.009_bib0050) 2015; 220 Demeter (10.1016/j.pneurobio.2015.12.009_bib0295) 2012; 119 Marin (10.1016/j.pneurobio.2015.12.009_bib0785) 2000; 36 Pittaluga (10.1016/j.pneurobio.2015.12.009_bib0990) 2001; 76 Tufi (10.1016/j.pneurobio.2015.12.009_bib1265) 2014; 16 Fukui (10.1016/j.pneurobio.2015.12.009_bib0385) 1991; 56 Steiner (10.1016/j.pneurobio.2015.12.009_bib1185) 2011; 8 Vazey (10.1016/j.pneurobio.2015.12.009_bib1290) 2006; 199 Portela (10.1016/j.pneurobio.2015.12.009_bib1005) 2010; 28 Venero (10.1016/j.pneurobio.2015.12.009_bib1300) 1995; 672 Adams (10.1016/j.pneurobio.2015.12.009_bib0005) 2012; 72 Barcia (10.1016/j.pneurobio.2015.12.009_bib0075) 2012; 3 Singh (10.1016/j.pneurobio.2015.12.009_bib1145) 2011; 257 Nakao (10.1016/j.pneurobio.2015.12.009_bib0875) 1996; 73 Proukakis (10.1016/j.pneurobio.2015.12.009_bib1020) 2014; 29 Merino (10.1016/j.pneurobio.2015.12.009_bib0815) 1999; 73 Chu (10.1016/j.pneurobio.2015.12.009_bib0255) 2014; 10 Finsterwald (10.1016/j.pneurobio.2015.12.009_bib0360) 2015; 21 Guillemin (10.1016/j.pneurobio.2015.12.009_bib0540) 2007; 1304 Smith (10.1016/j.pneurobio.2015.12.009_bib1155) 2009; 15 Goda (10.1016/j.pneurobio.2015.12.009_bib0420) 1996; 398 Beal (10.1016/j.pneurobio.2015.12.009_bib0110) 1992; 108 Chen (10.1016/j.pneurobio.2015.12.009_bib0245) 2010; 18 Garcia-Esparcia (10.1016/j.pneurobio.2015.12.009_bib0405) 2015; 41 Bordelon (10.1016/j.pneurobio.2015.12.009_bib0150) 1998; 83 Stone (10.1016/j.pneurobio.2015.12.009_bib1220) 2000; 21 Schapira (10.1016/j.pneurobio.2015.12.009_bib1110) 1993; 60 Deleidi (10.1016/j.pneurobio.2015.12.009_bib0290) 2013; 70 Forno (10.1016/j.pneurobio.2015.12.009_bib0365) 1992; 94 Guillemin (10.1016/j.pneurobio.2015.12.009_bib0510) 2003; 527 Anderson (10.1016/j.pneurobio.2015.12.009_bib0040) 2014; 49 Steiner (10.1016/j.pneurobio.2015.12.009_bib1180) 2011; 8 Guillemin (10.1016/j.pneurobio.2015.12.009_bib0520) 2005; 7 Shear (10.1016/j.pneurobio.2015.12.009_bib1135) 1998; 150 Chen (10.1016/j.pneurobio.2015.12.009_bib0230) 2009; 1 Fujigaki (10.1016/j.pneurobio.2015.12.009_bib0380) 2001; 31 Barcia (10.1016/j.pneurobio.2015.12.009_bib0070) 2012; 2 Jones (10.1016/j.pneurobio.2015.12.009_bib0650) 2013; 6 Lim (10.1016/j.pneurobio.2015.12.009_bib0750) 2010; 3 Brundin (10.1016/j.pneurobio.2015.12.009_bib0185) 2011; 11 Kubesova (10.1016/j.pneurobio.2015.12.009_bib0705) 2015; 10 Chen (10.1016/j.pneurobio.2015.12.009_bib0235) 2009; 2 Guillemin (10.1016/j.pneurobio.2015.12.009_bib0535) 2006; 2 Van der Perren (10.1016/j.pneurobio.2015.12.009_bib1280) 2015; 36 Stone (10.1016/j.pneurobio.2015.12.009_bib1205) 2002; 1 Cammer (10.1016/j.pneurobio.2015.12.009_bib0215) 2002; 327 Beck (10.1016/j.pneurobio.2015.12.009_bib0115) 2004; 13 Ghorayeb (10.1016/j.pneurobio.2015.12.009_bib0415) 2001; 167 Lewitt (10.1016/j.pneurobio.2015.12.009_bib0730) 2013; 28 Knyihar-Csillik (10.1016/j.pneurobio.2015.12.009_bib0680) 2006; 112 Khan (10.1016/j.pneurobio.2015.12.009_bib0660) 2013; 62 Silva-Adaya (10.1016/j.pneurobio.2015.12.009_bib1140) 2011; 33 Herrero (10.1016/j.pneurobio.2015.12.009_bib0590) 2015; 9 Widner (10.1016/j.pneurobio.2015.12.009_bib1325) 2002; 16 Lill (10.1016/j.pneurobio.2015.12.009_bib0740) 2012; 8 Braidy (10.1016/j.pneurobio.2015.12.009_bib0170) 2009; 2 Erhardt (10.1016/j.pneurobio.2015.12.009_bib0335) 2013; 38 Reeve (10.1016/j.pneurobio.2015.12.009_bib1040) 2014; 14 Aguilera (10.1016/j.pneurobio.2015.12.009_bib0015) 2007; 28 Anderson (10.1016/j.pneurobio.2015.12.009_bib0035) 2014; 13 Guillemin (10.1016/j.pneurobio.2015.12.009_bib0500) 2001; 118 Kumar (10.1016/j.pneurobio.2015.12.009_bib0710) 2004; 49 Moffett (10.1016/j.pneurobio.2015.12.009_bib0840) 1997; 144 Behan (10.1016/j.pneurobio.2015.12.009_bib0120) 2002; 135 Ouattara (10.1016/j.pneurobio.2015.12.009_bib0925) 2009; 38 Godbolt (10.1016/j.pneurobio.2015.12.009_bib0425) 2004; 63 Guillemin (10.1016/j.pneurobio.2015.12.009_bib0550) 2012; 279 Zadori (10.1016/j.pneurobio.2015.12.009_bib1360) 2012; 119 Holtze (10.1016/j.pneurobio.2015.12.009_bib0610) 2008; 86 Lee do (10.1016/j.pneurobio.2015.12.009_bib0715) 2008; 87 Fernandez-Gomez (10.1016/j.pneurobio.2015.12.009_bib0355) 2006; 24 Goldstein (10.1016/j.pneurobio.2015.12.009_bib0440) 2000; 39 Pérez-De La Cruz (10.1016/j.pneurobio.2015.12.009_bib0935) 2011 Behan (10.1016/j.pneurobio.2015.12.009_bib0130) 1999; 128 Bordelon (10.1016/j.pneurobio.2015.12.009_bib0145) 1997; 69 Bessede (10.1016/j.pneurobio.2015.12.009_bib0140) 2014; 511 Guillemin (10.1016/j.pneurobio.2015.12.009_bib0505) 2003; 41 Stone (10.1016/j.pneurobio.2015.12.009_bib1195) 2002; 447 Luchowski (10.1016/j.pneurobio.2015.12.009_bib0770) 2002; 330 Cabezas (10.1016/j.pneurobio.2015.12.009_bib0200) 2014; 8 Chen (10.1016/j.pneurobio.2015.12.009_bib0240) 2010; 118 Behan (10.1016/j.pneurobio.2015.12.009_bib0125) 1999; 128 Németh (10.1016/j.pneurobio.2015.12.009_bib0870) 2006 Recasens (10.1016/j.pneurobio.2015.12.009_bib1035) 2014; 8 Capuron (10.1016/j.pneurobio.2015.12.009_bib0220) 2011; 130 Urenjak (10.1016/j.pneurobio.2015.12.009_bib1270) 2000; 75 Torok (10.1016/j.pneurobio.2015.12.009_bib1260) 2015; 2015 Amaral (10.1016/j.pneurobio.2015.12.009_bib0030) 2013; 496 Eastman (10.1016/j.pneurobio.2015.12.009_bib0325) 1990; 15 Platenik (10.1016/j.pneurobio.2015.12.009_bib0995) 2001; 34 Braak (10.1016/j.pneurobio.2015.12.009_bib0155) 2003; 24 Fazio (10.1016/j.pneurobio.2015.12.009_bib0345) 2012; 81 Kieburtz (10.1016/j.pneurobio.2015.12.009_bib0665) 2013; 28 Hamann (10.1016/j.pneurobio.2015.12.009_bib0565) 2008; 586 Peterson (10.1016/j.pneurobio.2015.12.009_bib0970) 2012; 2012 Barcia (10.1016/j.pneurobio.2015.12.009_bib0060) 2004; 46 Knyihar-Csillik (10.1016/j.pneurobio.2015.12.009_bib0675) 2004; 126 Eastman (10.1016/j.pneurobio.2015.12.009_bib0320) 1989; 495 Czlonkowska (10.1016/j.pneurobio.2015.12.009_bib0275) 1996; 5 Ting (10.1016/j.pneurobio.2015.12.009_bib1250) 2007; 12 Wonodi (10.1016/j.pneurobio.2015.12.009_bib1340) 2011; 68 Mellor (10.1016/j.pneurobio.2015.12.009_bib0810) 2003; 171 Savitz (10.1016/j.pneurobio.2015.12.009_bib1100) 2015; 40 Baltazar (10.1016/j.pneurobio.2015.12.009_bib0055) 2014; 230 Dahm (10.1016/j.pneurobio.2015.12.009_bib0280) 2006; 281 Wu (10.1016/j.pneurobio.2015.12.009_bib1345) 2000; 390 Naviaux (10.1016/j.pneurobio.2015.12.009_bib0895) 2014; 16 Massudi (10.1016/j.pneurobio.2015.12.009_bib0790) 2012; 17 Braidy (10.1016/j.pneurobio.2015.12.009_bib0165) 2009; 16 Guillemin (10.1016/j.pneurobio.2015.12.009_bib0545) 2007; 27 Sundaram (10.1016/j.pneurobio.2015.12.009_bib1225) 2014; 11 Kravzov (10.1016/j.pneurobio.2015.12.009_bib0700) 1993; 36 Jang (10.1016/j.pneurobio.2015.12.009_bib0625) 2009; 106 Perez-De La Cruz (10.1016/j.pneurobio.2015.12.009_bib0945) 2007; 6 Valero (10.1016/j.pneurobio.2015.12.009_bib1275) 2014; 20 Hartai (10.1016/j.pneurobio.2015.12.009_bib0575) 2005; 112 Han (10.1016/j.pneurobio.2015.12.009_bib0570) 2015; 290 Iwahashi (10.1016/j.pneurobio.2015.12.009_bib0620) 1988; 251 Hartai (10.1016/j.pneurobio.2015.12.009_bib0585) 2005; 239 Lugo-Huitron (10.1016/j.pneurobio.2015.12.009_bib0775) 2011; 33 Braak (10.1016/j.pneurobio.2015.12.009_bib0160) 2006 Bay-Richter (10.1016/j.pneurobio.2015.12.009_bib0095) 2015; 43 Nam (10.1016/j.pneurobio.2015.12.009_bib0890) 2015; 138 Sanberg (10.1016/j.pneurobio.2015.12.009_bib1075) 1989; 105 Perez-De La Cruz (10.1016/j.pneurobio.2015.12.009_bib0955) 2012; 5 Solano (10.1016/j.pneurobio.2015.12.009_bib1160) 2006; 51 Schwarcz (10.1016/j.pneurobio.2015.12.009_bib1125) 1983; 38 Lee (10.1016/j.pneurobio.2015.12.009_bib0720) 2010; 5 Berg (10.1016/j.pneurobio.2015.12.009_bib0135) 2014; 29 Grant (10.1016/j.pneurobio.2015.12.009_bib0455) 2009; 2009 Tavares (10.1016/j.pneurobio.2015.12.009_bib1240) 2002; 40 Pringsheim (10.1016/j.pneurobio.2015.12.009_bib1015) 2014; 29 Zadori (10.1016/j.pneurobio.2015.12.009_bib1355) 2011; 55 Groves (10.1016/j.pneurobio.2015.12.009_bib0470) 2013; 18 Zaitone (10.1016/j.pneurobio.2015.12.009_bib1365) 2012; 100 Hill-Burns (10.1016/j.pneurobio.2015.12.009_bib |
| References_xml | – volume: 21 start-page: 3570 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib0360 article-title: Astrocytes: new targets for the treatment of neurodegenerative diseases publication-title: Curr. Pharm. Des. doi: 10.2174/1381612821666150710144502 contributor: fullname: Finsterwald – volume: 224 start-page: 188 year: 2010 ident: 10.1016/j.pneurobio.2015.12.009_bib0985 article-title: Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2010.03.009 contributor: fullname: Pierozan – start-page: 324 year: 2007 ident: 10.1016/j.pneurobio.2015.12.009_bib0490 article-title: Chronic HIV infection leads to an Alzheimer's disease like illness. Involvement of the kynurenine pathway contributor: fullname: Guillemin – volume: 29 start-page: 1583 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib1015 article-title: The prevalence of Parkinson's disease: a systematic review and meta-analysis publication-title: Mov. Disord. doi: 10.1002/mds.25945 contributor: fullname: Pringsheim – volume: 109 start-page: 181 year: 2002 ident: 10.1016/j.pneurobio.2015.12.009_bib1330 article-title: Increased neopterin production and tryptophan degradation in advanced Parkinson's disease publication-title: J. Neural Transm. doi: 10.1007/s007020200014 contributor: fullname: Widner – volume: 5 start-page: e14123 year: 2010 ident: 10.1016/j.pneurobio.2015.12.009_bib0720 article-title: Characterisation of the expression of NMDA receptors in human astrocytes publication-title: PLoS One doi: 10.1371/journal.pone.0014123 contributor: fullname: Lee – volume: 257 start-page: 84 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib1145 article-title: Role of genetic polymorphisms of CYP1A1CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2011.08.021 contributor: fullname: Singh – volume: 8 start-page: e1002548 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0740 article-title: Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: the PDGene database publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1002548 contributor: fullname: Lill – volume: 55 start-page: 540 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib1355 article-title: Time-course of kynurenic acid concentration in mouse serum following the administration of a novel kynurenic acid analog publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2011.02.014 contributor: fullname: Zadori – volume: 2 start-page: 809 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0070 article-title: ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo publication-title: Sci. Rep. doi: 10.1038/srep00809 contributor: fullname: Barcia – volume: 16 start-page: 77 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib0165 article-title: Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons publication-title: Neurotox. Res. doi: 10.1007/s12640-009-9051-z contributor: fullname: Braidy – volume: 4 start-page: 218 year: 1997 ident: 10.1016/j.pneurobio.2015.12.009_bib0195 article-title: The effects of reversible inactivation of the subthalamo-pallidal pathway on the behaviour of naive and hemiparkinsonian monkeys publication-title: J. Clin. Neurosci. doi: 10.1016/S0967-5868(97)90076-X contributor: fullname: Butler – volume: 72 start-page: 624 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib1080 article-title: alpha-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1097/NEN.0b013e31829768d2 contributor: fullname: Sanchez-Guajardo – volume: 33 start-page: 303 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib1140 article-title: Protective effect of L-kynurenine and probenecid on 6-hydroxydopamine-induced striatal toxicity in rats: implications of modulating kynurenate as a protective strategy publication-title: Neurotoxicol. Teratol. doi: 10.1016/j.ntt.2010.10.002 contributor: fullname: Silva-Adaya – volume: 41 start-page: 371 year: 2003 ident: 10.1016/j.pneurobio.2015.12.009_bib0505 article-title: Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes publication-title: Glia doi: 10.1002/glia.10175 contributor: fullname: Guillemin – volume: 39 start-page: 7266 year: 2000 ident: 10.1016/j.pneurobio.2015.12.009_bib0440 article-title: 3- Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction publication-title: Biochemistry doi: 10.1021/bi992997s contributor: fullname: Goldstein – volume: 566 start-page: 72 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0695 article-title: Effects of L-tryptophan on L-DOPA-induced dyskinesia in the L-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque model of Parkinson's disease publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2014.02.027 contributor: fullname: Ko – volume: 2 start-page: 61 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib0170 article-title: Effects of kynurenine pathway metabolites on intracellular NAD+ synthesis and cell death in human primary astrocytes and neurons publication-title: Int. J. Trypto. Res doi: 10.4137/IJTR.S2318 contributor: fullname: Braidy – volume: 896 start-page: 157 year: 2001 ident: 10.1016/j.pneurobio.2015.12.009_bib0210 article-title: Oligodendrocyte killing by quinolinic acid in vitro publication-title: Brain Res. doi: 10.1016/S0006-8993(01)02017-0 contributor: fullname: Cammer – volume: 78 start-page: 967 year: 1997 ident: 10.1016/j.pneurobio.2015.12.009_bib0830 article-title: Protection against quinolinic acid-mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid publication-title: Neuroscience doi: 10.1016/S0306-4522(96)00655-0 contributor: fullname: Miranda – volume: 280 start-page: 5030 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0330 article-title: Rotenone induces neuronal death by microglial phagocytosis of neurons publication-title: FEBS J. doi: 10.1111/febs.12401 contributor: fullname: Emmrich – volume: 7 start-page: 199 year: 2002 ident: 10.1016/j.pneurobio.2015.12.009_bib0480 article-title: Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease publication-title: Redox Rep. doi: 10.1179/135100002125000550 contributor: fullname: Guillemin – volume: 17 start-page: 130 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib0860 article-title: Kynurenine pathway in schizophrenia: pathophysiological and therapeutic aspects publication-title: Curr. Pharm. Des. doi: 10.2174/138161211795049552 contributor: fullname: Muller – volume: 119 start-page: 261 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib1210 article-title: Involvement of kynurenines in Huntington's disease and stroke-induced brain damage publication-title: J. Neural Transm. doi: 10.1007/s00702-011-0676-8 contributor: fullname: Stone – volume: 15 start-page: 1101 year: 1990 ident: 10.1016/j.pneurobio.2015.12.009_bib0325 article-title: The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine publication-title: Neurochem. Res. doi: 10.1007/BF01101711 contributor: fullname: Eastman – volume: 248 start-page: 19189 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib0085 article-title: Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.024042 contributor: fullname: Barth – volume: 281 start-page: 10056 year: 2006 ident: 10.1016/j.pneurobio.2015.12.009_bib0280 article-title: Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the interaction of nitric oxide with mitochondria publication-title: J. Biol. Chem. doi: 10.1074/jbc.M512203200 contributor: fullname: Dahm – volume: 256 start-page: 105 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0850 article-title: Modeling dyskinesia in animal models of Parkinson disease publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2013.01.024 contributor: fullname: Morin – volume: 24 start-page: 825 year: 1993 ident: 10.1016/j.pneurobio.2015.12.009_bib1215 article-title: Subtypes of NMDA receptors publication-title: Gen. Pharmacol. doi: 10.1016/0306-3623(93)90155-Q contributor: fullname: Stone – volume: 66 start-page: 133 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0265 article-title: Actions of Xanthurenic acid a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2012.03.009 contributor: fullname: Copeland – volume: 17 start-page: 28 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0790 article-title: NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns publication-title: Redox Rep. doi: 10.1179/1351000212Y.0000000001 contributor: fullname: Massudi – volume: 56 start-page: 2007 year: 1991 ident: 10.1016/j.pneurobio.2015.12.009_bib0385 article-title: Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.1991.tb03460.x contributor: fullname: Fukui – start-page: 285 year: 2006 ident: 10.1016/j.pneurobio.2015.12.009_bib0870 article-title: Kynurenines, Parkinson's disease and other neurodegenerative disorders: preclinical and clinical studies publication-title: J. Neural Transm. Suppl. contributor: fullname: Németh – start-page: 1 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib1175 article-title: Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity publication-title: World J. Biol. Psychiatry contributor: fullname: Steiner – volume: 28 start-page: 1653 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0730 article-title: Parkinson's Disease 3- hydroxykynurenine and other Parkinson's disease biomarkers discovered by metabolomic analysis publication-title: Mov. Disord. doi: 10.1002/mds.25555 contributor: fullname: Lewitt – volume: 11 start-page: 249 year: 2000 ident: 10.1016/j.pneurobio.2015.12.009_bib1235 article-title: Quinolinic acid inhibits glutamate uptake into synaptic vesicles from rat brain publication-title: Neuroreport doi: 10.1097/00001756-200002070-00005 contributor: fullname: Tavares – volume: 268 start-page: 157 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0855 article-title: Pesticides and human chronic diseases: evidences mechanisms, and perspectives publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2013.01.025 contributor: fullname: Mostafalou – volume: 6 start-page: 15 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0340 article-title: Role of NAD(+) oxidative stress, and tryptophan metabolism in autism spectrum disorders publication-title: Int J Tryptophan Res contributor: fullname: Essa – volume: 78 start-page: 1 year: 2001 ident: 10.1016/j.pneurobio.2015.12.009_bib0495 article-title: Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2001.00498.x contributor: fullname: Guillemin – volume: 167 start-page: 133 year: 2001 ident: 10.1016/j.pneurobio.2015.12.009_bib0415 article-title: Simultaneous intrastriatal 6-hydroxydopamine and quinolinic acid injection: a model of early-stage striatonigral degeneration publication-title: Exp. Neurol. doi: 10.1006/exnr.2000.7535 contributor: fullname: Ghorayeb – volume: 2 start-page: e142 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib0065 article-title: IFN-gamma signaling, with the synergistic contribution of TNF-alpha, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease publication-title: Cell Death Dis. doi: 10.1038/cddis.2011.17 contributor: fullname: Barcia – year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0090 article-title: A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality publication-title: Brain Behav. Immun. contributor: fullname: Bay-Richter – volume: 112 start-page: 127 year: 2006 ident: 10.1016/j.pneurobio.2015.12.009_bib0685 article-title: Effect of 6-hydroxydopamine treatment on kynurenine aminotransferase-I (KAT-I) immunoreactivity of neurons and glial cells in the rat substantia nigra publication-title: Acta Neuropathol. doi: 10.1007/s00401-006-0086-4 contributor: fullname: Knyihar-Csillik – volume: 75 start-page: 4656 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0735 article-title: Proteomic profiling of the substantia nigra demonstrates CNDP2 overexpression in Parkinson's disease publication-title: J. Proteomics doi: 10.1016/j.jprot.2012.02.032 contributor: fullname: Licker – volume: 21 start-page: 149 year: 2000 ident: 10.1016/j.pneurobio.2015.12.009_bib1220 article-title: Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection publication-title: Trends Pharmacol. Sci. doi: 10.1016/S0165-6147(00)01451-6 contributor: fullname: Stone – volume: 128 start-page: 1754 year: 1999 ident: 10.1016/j.pneurobio.2015.12.009_bib0125 article-title: Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0702940 contributor: fullname: Behan – volume: 13 start-page: 817 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0035 article-title: Local melatonin regulates inflammation resolution: a common factor in neurodegenerative: psychiatric and systemic inflammatory disorders publication-title: CNS & neurological disorders drug targets doi: 10.2174/1871527313666140711091400 contributor: fullname: Anderson – volume: 529 start-page: 185 year: 1990 ident: 10.1016/j.pneurobio.2015.12.009_bib0640 article-title: Quinolinate-induced cortical cholinergic damage: modulation by tryptophan metabolites publication-title: Brain Res. doi: 10.1016/0006-8993(90)90826-W contributor: fullname: Jhamandas – volume: 12 start-page: 247 year: 2007 ident: 10.1016/j.pneurobio.2015.12.009_bib1250 article-title: The involvement of astrocytes and kynurenine pathway in Alzheimer's disease publication-title: Neurotox. Res. doi: 10.1007/BF03033908 contributor: fullname: Ting – volume: 171 start-page: 1652 year: 2003 ident: 10.1016/j.pneurobio.2015.12.009_bib0810 article-title: Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion publication-title: J. Immunol. doi: 10.4049/jimmunol.171.4.1652 contributor: fullname: Mellor – volume: 1852 start-page: 451 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib1010 article-title: TNF-alpha regulates miRNA targeting mitochondrial complex-I and induces cell death in dopaminergic cells publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2014.11.019 contributor: fullname: Prajapati – volume: 62 start-page: 379 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0660 article-title: Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol publication-title: Neurochem. Int. doi: 10.1016/j.neuint.2013.01.029 contributor: fullname: Khan – volume: 527 start-page: 105 year: 2003 ident: 10.1016/j.pneurobio.2015.12.009_bib0510 article-title: Expression of the kynurenine pathway enzymes in human microglia and macrophages publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-1-4615-0135-0_12 contributor: fullname: Guillemin – volume: 86 start-page: 3674 issue: 16 year: 2008 ident: 10.1016/j.pneurobio.2015.12.009_bib0610 article-title: Induction of the kynurenine pathway by neurotropic influenza a virus infection publication-title: J. Neurosci. Res. doi: 10.1002/jnr.21799 contributor: fullname: Holtze – volume: 29 start-page: 454 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0135 article-title: Time to redefine PD?: Introductory statement of the MDS Task Force on the definition of Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.25844 contributor: fullname: Berg – volume: 99 start-page: 1531 year: 2006 ident: 10.1016/j.pneurobio.2015.12.009_bib1050 article-title: Evidence that quinolinic acid severely impairs energy metabolism through activation of NMDA receptors in striatum from developing rats publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2006.04199.x contributor: fullname: Ribeiro – volume: 81 start-page: 643 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0345 article-title: Cinnabarinic acid an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors publication-title: Mol. Pharmacol. doi: 10.1124/mol.111.074765 contributor: fullname: Fazio – volume: 73 start-page: 750 year: 1999 ident: 10.1016/j.pneurobio.2015.12.009_bib0815 article-title: The non-NMDA glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline but not NMDA antagonists, block the intrastriatal neurotoxic effect of MPP+ publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.1999.0730750.x contributor: fullname: Merino – volume: 110 start-page: 1540 year: 2007 ident: 10.1016/j.pneurobio.2015.12.009_bib1230 article-title: Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation publication-title: Blood doi: 10.1182/blood-2006-11-056010 contributor: fullname: Tas – volume: 1802 start-page: 29 year: 2010 ident: 10.1016/j.pneurobio.2015.12.009_bib1335 article-title: Mitochondrial dysfunction in Parkinson's disease publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2009.08.013 contributor: fullname: Winklhofer – volume: 2 start-page: 166 year: 2006 ident: 10.1016/j.pneurobio.2015.12.009_bib0535 article-title: Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis publication-title: Neurodegenerative Dis. doi: 10.1159/000089622 contributor: fullname: Guillemin – volume: 3 start-page: 216 year: 2002 ident: 10.1016/j.pneurobio.2015.12.009_bib0900 article-title: Innate immunity: the missing link in neuroprotection and neurodegeneration? publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn752 contributor: fullname: Nguyen – volume: 1 start-page: 609 year: 2002 ident: 10.1016/j.pneurobio.2015.12.009_bib1205 article-title: Endogenous kynurenines as targets for drug discovery and development publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd870 contributor: fullname: Stone – volume: 46 start-page: 402 year: 2004 ident: 10.1016/j.pneurobio.2015.12.009_bib0060 article-title: Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure publication-title: Glia doi: 10.1002/glia.20015 contributor: fullname: Barcia – volume: 2 start-page: 16 year: 2005 ident: 10.1016/j.pneurobio.2015.12.009_bib0530 article-title: Quinolinic acid selectively induces apoptosis of human astrocytes: potential role in AIDS dementia complex publication-title: J. Neuroinflammation doi: 10.1186/1742-2094-2-16 contributor: fullname: Guillemin – volume: 21 start-page: 7463 year: 2001 ident: 10.1016/j.pneurobio.2015.12.009_bib0605 article-title: The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.21-19-07463.2001 contributor: fullname: Hilmas – volume: 79 start-page: 115 year: 1998 ident: 10.1016/j.pneurobio.2015.12.009_bib1045 article-title: Changes in blood-brain barrier permeability following neurotoxic lesions of rat brain can be visualised with trypan blue publication-title: J. Neurosci. Methods doi: 10.1016/S0165-0270(97)00168-4 contributor: fullname: Reynolds – volume: 10 start-page: 376 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0255 article-title: LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons: implications for Parkinson disease publication-title: Autophagy doi: 10.4161/auto.27191 contributor: fullname: Chu – volume: 6 start-page: 639 year: 1992 ident: 10.1016/j.pneurobio.2015.12.009_bib0820 article-title: Effects of interferons beta or gamma on neopterin biosynthesis and tryptophan degradation by human alveolar macrophages in vitro: synergy with lipopolysaccharide publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/ajrcmb/6.6.639 contributor: fullname: Meyer – volume: 12 start-page: 2693 year: 2001 ident: 10.1016/j.pneurobio.2015.12.009_bib1095 article-title: In vivo hydroxyl radical formation after quinolinic acid infusion into rat corpus striatum publication-title: Neuroreport doi: 10.1097/00001756-200108280-00020 contributor: fullname: Santamaria – volume: 2009 start-page: 71 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib0455 article-title: The physiological action of picolinic acid in the human brain publication-title: Int. J. Tryptophan Res. contributor: fullname: Grant – volume: 38 start-page: 128 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib0925 article-title: Implication of NMDA receptors in the antidyskinetic activity of cabergoline CI-1041, and Ro 61–8048 in MPTP monkeys with levodopa-induced dyskinesias publication-title: J. Mol. Neurosci. doi: 10.1007/s12031-008-9137-8 contributor: fullname: Ouattara – volume: 290 start-page: 10325 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib0570 article-title: Nitric oxide induction of parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.624767 contributor: fullname: Han – volume: 16 start-page: 7 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0895 article-title: Metabolic features of the cell danger response publication-title: Mitochondrion doi: 10.1016/j.mito.2013.08.006 contributor: fullname: Naviaux – volume: 36 start-page: 267 year: 2000 ident: 10.1016/j.pneurobio.2015.12.009_bib0785 article-title: Non-NMDA receptor-mediated mechanisms are involved in levodopa-induced motor response alterations in Parkinsonian rats publication-title: Synapse doi: 10.1002/(SICI)1098-2396(20000615)36:4<267::AID-SYN3>3.0.CO;2-Y contributor: fullname: Marin – volume: 5 start-page: 1 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0955 article-title: Quinolinic Acid an endogenous molecule combining excitotoxicity, oxidative stress and other toxic mechanisms publication-title: Int. J. Tryptophan Res. contributor: fullname: Perez-De La Cruz – volume: 1304 start-page: 404 year: 2007 ident: 10.1016/j.pneurobio.2015.12.009_bib0540 article-title: Mass spectrometric detection of quinolinic acid in microdissected Alzheimer disease plaques publication-title: Int. Congress Series doi: 10.1016/j.ics.2007.07.012 contributor: fullname: Guillemin – volume: 190 start-page: 5048 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0445 article-title: Dopamine receptor D3 expressed on CD4+ T cells favors neurodegeneration of dopaminergic neurons during Parkinson's disease publication-title: J. Immunol. doi: 10.4049/jimmunol.1203121 contributor: fullname: Gonzalez – volume: 6 start-page: e27109 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib0600 article-title: Evidence for more than one Parkinson's disease-associated variant within the HLA region publication-title: PLoS One doi: 10.1371/journal.pone.0027109 contributor: fullname: Hill-Burns – volume: 86 start-page: 410 year: 1984 ident: 10.1016/j.pneurobio.2015.12.009_bib0795 article-title: Neurotoxic effects of endogenous materials: quinolinic acid, L-pyroglutamic acid, and thyroid releasing hormone publication-title: Exp. Neurol. doi: 10.1016/0014-4886(84)90197-3 contributor: fullname: McGeer – volume: 496 start-page: 382 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0030 article-title: Structural basis of kynurenine 3-monooxygenase inhibition publication-title: Nature doi: 10.1038/nature12039 contributor: fullname: Amaral – volume: 130 start-page: 226 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib0220 article-title: Immune system to brain signaling: neuropsychopharmacological implications publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2011.01.014 contributor: fullname: Capuron – year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib0935 article-title: Quinolinic acid, an endogenous molecule combining excitotoxicity, oxidative stress and other toxic mechanisms publication-title: FEBS J. contributor: fullname: Pérez-De La Cruz – start-page: 89 year: 2006 ident: 10.1016/j.pneurobio.2015.12.009_bib0160 article-title: Pathology associated with sporadic Parkinson's disease–where does it end? publication-title: J. Neural Transm. Suppl. contributor: fullname: Braak – volume: 11 start-page: 917 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib0185 article-title: Can alpha-synuclein be targeted in novel therapies for Parkinson's disease? publication-title: Expert Rev. Neurother. doi: 10.1586/ern.11.73 contributor: fullname: Brundin – volume: 18 start-page: 132 year: 2010 ident: 10.1016/j.pneurobio.2015.12.009_bib0245 article-title: The kynurenine pathway and inflammation in amyotrophic lateral sclerosis publication-title: Neurotox. Res. doi: 10.1007/s12640-009-9129-7 contributor: fullname: Chen – volume: 87 start-page: 389 year: 2008 ident: 10.1016/j.pneurobio.2015.12.009_bib0715 article-title: Kynurenic acid attenuates MPP(+)-induced dopaminergic neuronal cell death via a Bax-mediated mitochondrial pathway publication-title: Eur. J. Cell Biol. doi: 10.1016/j.ejcb.2008.03.003 contributor: fullname: Lee do – volume: 138 start-page: 3610 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib0890 article-title: TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF publication-title: Brain doi: 10.1093/brain/awv297 contributor: fullname: Nam – volume: 46 start-page: 989 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0880 article-title: Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease publication-title: Nat. Genet. doi: 10.1038/ng.3043 contributor: fullname: Nalls – volume: 495 start-page: 225 year: 1989 ident: 10.1016/j.pneurobio.2015.12.009_bib0320 article-title: Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line publication-title: Brain Res. doi: 10.1016/0006-8993(89)90216-3 contributor: fullname: Eastman – volume: 226 start-page: 551 year: 1983 ident: 10.1016/j.pneurobio.2015.12.009_bib0965 article-title: Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system publication-title: J. Pharm. Exp. Ther. contributor: fullname: Perkins – volume: 130 start-page: 39 year: 1995 ident: 10.1016/j.pneurobio.2015.12.009_bib0635 article-title: Dysfunction of brain kynurenic acid metabolism in Huntington's disease: focus on kynurenine aminotransferases publication-title: J. Neurol. Sci. doi: 10.1016/0022-510X(94)00280-2 contributor: fullname: Jauch – volume: 667 start-page: 182 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib0410 article-title: Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2011.05.069 contributor: fullname: Gellert – volume: 330 start-page: 49 year: 2002 ident: 10.1016/j.pneurobio.2015.12.009_bib0770 article-title: 1-Methyl-4-phenylpyridinium and 3-nitropropionic acid diminish cortical synthesis of kynurenic acid via interference with kynurenine aminotransferases in rats publication-title: Neurosci. Lett. doi: 10.1016/S0304-3940(02)00735-8 contributor: fullname: Luchowski – volume: 8 start-page: 1 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib1185 article-title: Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? publication-title: J. Neuroinflammation doi: 10.1186/1742-2094-8-94 contributor: fullname: Steiner – volume: 26 start-page: 127 year: 2002 ident: 10.1016/j.pneurobio.2015.12.009_bib0205 article-title: Alteration of glutamate receptors in the striatum of dyskinetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys following dopamine agonist treatment publication-title: ProgressNeuro-Psychopharmacol. Biol. Psychiatr. doi: 10.1016/S0278-5846(01)00237-8 contributor: fullname: Calon – volume: 119 start-page: 151 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0845 article-title: Interaction of adenosine receptors with other receptors from therapeutic perspective in parkinson's disease publication-title: Adenosine Receptors Neurol. Psychiatry doi: 10.1016/B978-0-12-801022-8.00007-6 contributor: fullname: Morin – volume: 31 start-page: 395 year: 2005 ident: 10.1016/j.pneurobio.2015.12.009_bib0515 article-title: Indoleamine 2,3 dioxygenase and quinolinic acid in plaque and neurons in post-mortem brain tissue from Alzheimer‘s disease and control cases publication-title: Neuropathol. Appl. Neurobiol. doi: 10.1111/j.1365-2990.2005.00655.x contributor: fullname: Guillemin – volume: 61 start-page: 429 year: 2008 ident: 10.1016/j.pneurobio.2015.12.009_bib0690 article-title: The kynurenate analog SZR-72 prevents the nitroglycerol-induced increase of c-fos immunoreactivity in the rat caudal trigeminal nucleus: comparative studies of the effects of SZR-72 and kynurenic acid publication-title: Neurosci. Res. doi: 10.1016/j.neures.2008.04.009 contributor: fullname: Knyihar-Csillik – volume: 398 start-page: 247 year: 1996 ident: 10.1016/j.pneurobio.2015.12.009_bib0420 article-title: Quinolinic acid and active oxygens: possible contribution of active Oxygens during cell death in the brain publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-1-4613-0381-7_38 contributor: fullname: Goda – volume: 17 start-page: 589 year: 1997 ident: 10.1016/j.pneurobio.2015.12.009_bib0940 article-title: Quinolinic acid production by macrophages stimulated with IFN-gamma TNF-alpha, and IFN-alpha publication-title: J. Interferon Cytokine Res. doi: 10.1089/jir.1997.17.589 contributor: fullname: Pemberton – volume: 2015 start-page: 474135 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib1260 article-title: The genetic link between parkinson's disease and the kynurenine pathway is still missing publication-title: Parkinsons Dis. contributor: fullname: Torok – volume: 16 start-page: 1139 year: 1991 ident: 10.1016/j.pneurobio.2015.12.009_bib1055 article-title: Quinolinic acid is a potent lipid peroxidant in rat brain homogenates publication-title: Neurochem. Res. doi: 10.1007/BF00966592 contributor: fullname: Rios – volume: 47 start-page: 219 year: 1996 ident: 10.1016/j.pneurobio.2015.12.009_bib0595 article-title: GAD mRNA expression in medial pallidal neurons in MPTP-treated monkey and Parkinson’s disease publication-title: Neurology doi: 10.1212/WNL.47.1.219 contributor: fullname: Herrero – volume: 11 start-page: 3857 year: 1999 ident: 10.1016/j.pneurobio.2015.12.009_bib0475 article-title: 3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum publication-title: Eur. J. Neurosci. doi: 10.1046/j.1460-9568.1999.00806.x contributor: fullname: Guidetti – volume: 40 start-page: 621 year: 2002 ident: 10.1016/j.pneurobio.2015.12.009_bib1240 article-title: Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes publication-title: Neurochem. Int. doi: 10.1016/S0197-0186(01)00133-4 contributor: fullname: Tavares – volume: 108 start-page: 80 year: 1992 ident: 10.1016/j.pneurobio.2015.12.009_bib0110 article-title: Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex publication-title: J. Neurol. Sci. doi: 10.1016/0022-510X(92)90191-M contributor: fullname: Beal – volume: 221 start-page: 13 year: 2010 ident: 10.1016/j.pneurobio.2015.12.009_bib1305 article-title: The sour side of neurodegenerative disorders: the effects of protein glycation publication-title: J. Pathol. doi: 10.1002/path.2682 contributor: fullname: Vicente Miranda – volume: 24 start-page: 197 year: 2003 ident: 10.1016/j.pneurobio.2015.12.009_bib0155 article-title: Staging of brain pathology related to sporadic Parkinson's disease publication-title: Neurobiol. Aging doi: 10.1016/S0197-4580(02)00065-9 contributor: fullname: Braak – volume: 33 start-page: 538 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib0775 article-title: On the antioxidant properties of kynurenic acid: free radical scavenging activity and inhibition of oxidative stress publication-title: Neurotoxicol. Teratol. doi: 10.1016/j.ntt.2011.07.002 contributor: fullname: Lugo-Huitron – volume: 83 start-page: 459 year: 1998 ident: 10.1016/j.pneurobio.2015.12.009_bib0150 article-title: Effects of intrastriatal injection of quinolinic acid on electrical activity and extracellular ion concentrations in rat striatum in vivo publication-title: Neuroscience doi: 10.1016/S0306-4522(97)00421-1 contributor: fullname: Bordelon – volume: 115 start-page: 89 year: 2010 ident: 10.1016/j.pneurobio.2015.12.009_bib0305 article-title: Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfq024 contributor: fullname: DiNatale – volume: 32 start-page: 521 year: 2008 ident: 10.1016/j.pneurobio.2015.12.009_bib0980 article-title: Different methylation of the TNF-alpha promoter in cortex and substantia nigra: implications for selective neuronal vulnerability publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2008.09.010 contributor: fullname: Pieper – volume: 133 start-page: 959 year: 2005 ident: 10.1016/j.pneurobio.2015.12.009_bib0350 article-title: Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions publication-title: Neuroscience doi: 10.1016/j.neuroscience.2005.03.019 contributor: fullname: Fernandez-Gomez – volume: 15 start-page: 303 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib1155 article-title: 5-Hydroxyanthranilic acid a tryptophan metabolite, generates oxidative stress and neuronal death via p38 activation in cultured cerebellar granule neurones publication-title: Neurotox. Res. doi: 10.1007/s12640-009-9034-0 contributor: fullname: Smith – volume: 76 start-page: 137 issue: Pt A year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0390 article-title: Zonisamide regulates basal ganglia transmission via astroglial kynurenine pathway publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2013.08.002 contributor: fullname: Fukuyama – volume: 617 start-page: 76 year: 1993 ident: 10.1016/j.pneurobio.2015.12.009_bib1120 article-title: Quinolinate potentiates the neurotoxicity of excitatory amino acids in hypoxic neuronal tissue in vitro publication-title: Brain Res. doi: 10.1016/0006-8993(93)90615-T contributor: fullname: Schurr – volume: 7 start-page: e47387 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0755 article-title: Non-motor symptoms in patients with Parkinson's disease—correlations with inflammatory cytokines in serum publication-title: PLoS One doi: 10.1371/journal.pone.0047387 contributor: fullname: Lindqvist – volume: 13 start-page: 1219 issue: 12 year: 2004 ident: 10.1016/j.pneurobio.2015.12.009_bib0115 article-title: Somatic and germline mosaicism in sporadic early-onset Alzheimer’s disease publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddh134 contributor: fullname: Beck – volume: 60 start-page: 491 year: 1985 ident: 10.1016/j.pneurobio.2015.12.009_bib1245 article-title: The iron-chelating agent picolinic acid enhances transferrin receptors expression in human erythroleukaemic cell lines publication-title: Br. J. Haematol. doi: 10.1111/j.1365-2141.1985.tb07446.x contributor: fullname: Testa – volume: 220 start-page: 703 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib0050 article-title: Metalloproteinase-9 contributes to inflammatory glia activation and nigro-striatal pathway degeneration in both mouse and monkey models of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism publication-title: Brain Struct. Funct. doi: 10.1007/s00429-014-0718-8 contributor: fullname: Annese – volume: 16 start-page: 590 year: 2002 ident: 10.1016/j.pneurobio.2015.12.009_bib1325 article-title: Neopterin production, tryptophan degradation, and mental depression–what is the link? publication-title: Brain Behav. Immun. doi: 10.1016/S0889-1591(02)00006-5 contributor: fullname: Widner – volume: 239 start-page: 31 year: 2005 ident: 10.1016/j.pneurobio.2015.12.009_bib0580 article-title: Kynurenine metabolism in plasma and in red blood cells in Parkinson's disease publication-title: J. Neurol. Sci. doi: 10.1016/j.jns.2005.07.006 contributor: fullname: Hartai – volume: 7 start-page: 56 year: 2001 ident: 10.1016/j.pneurobio.2015.12.009_bib1150 article-title: Quinolinic acid is produced by macrophages stimulated platelet activating factor Nef and Tat publication-title: J. Neurovirol. doi: 10.1080/135502801300069692 contributor: fullname: Smith – volume: 23 start-page: 271 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0670 article-title: Hypothesis: somatic mosaicism and Parkinson disease publication-title: Exp Neurobiol doi: 10.5607/en.2014.23.4.271 contributor: fullname: Kim – volume: 2011 start-page: 716859 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib1380 article-title: The involvement of neuroinflammation and kynurenine pathway in Parkinson's disease publication-title: Parkinsons Dis. contributor: fullname: Zinger – volume: 36 start-page: 255 year: 1993 ident: 10.1016/j.pneurobio.2015.12.009_bib0700 article-title: Protective effect of probenecid on circling behavior of rats with unilateral quinollinic acid induced striatal lesions publication-title: Proc. West. Pharmacol. Soc. contributor: fullname: Kravzov – volume: 247 start-page: 184 year: 1982 ident: 10.1016/j.pneurobio.2015.12.009_bib0960 article-title: An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid publication-title: Brain Res. doi: 10.1016/0006-8993(82)91048-4 contributor: fullname: Perkins – volume: 129 start-page: 411 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib1165 article-title: Characterization of mitophagy in the 6-hydoxydopamine Parkinson's disease model publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfs218 contributor: fullname: Solesio – volume: 24 start-page: E34 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib1350 article-title: Acute onset of parkinsonism with reversible course after H1N1 vaccination: insight from a young lady publication-title: J. Neuropsychiatr. Clin. Neurosci. doi: 10.1176/appi.neuropsych.11110324 contributor: fullname: Yeh – volume: 72 start-page: 5649 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0005 article-title: The kynurenine pathway in brain tumor pathogenesis publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-12-0549 contributor: fullname: Adams – volume: 6 start-page: 57 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0650 article-title: The kynurenine pathway in stem cell biology publication-title: Int. J. Tryptophan. Res. doi: 10.4137/IJTR.S12626 contributor: fullname: Jones – volume: 49 start-page: 15 year: 2005 ident: 10.1016/j.pneurobio.2015.12.009_bib0525 article-title: Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia astrocytes, and neurons publication-title: Glia doi: 10.1002/glia.20090 contributor: fullname: Guillemin – volume: 11 start-page: 169 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0270 article-title: The kynurenine pathway is involved in bacterial meningitis publication-title: J. Neuroinflammation doi: 10.1186/s12974-014-0169-4 contributor: fullname: Coutinho – volume: 9 start-page: e112945 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0010 article-title: Involvement of the kynurenine pathway in human glioma pathophysiology publication-title: PLoS One doi: 10.1371/journal.pone.0112945 contributor: fullname: Adams – volume: 60 start-page: 1017 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib0905 article-title: Metabotropic glutamate receptors: from the workbench to the bedside publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2010.10.022 contributor: fullname: Nicoletti – volume: 125 start-page: 491 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib1115 article-title: Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies publication-title: J. Neurochem. doi: 10.1111/jnc.12226 contributor: fullname: Schildknecht – volume: 105 start-page: 1346 year: 2008 ident: 10.1016/j.pneurobio.2015.12.009_bib0930 article-title: Kynurenine pathway metabolism in human blood-brain-barrier cells: implications for immune tolerance and neurotoxicity publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2008.05241.x contributor: fullname: Owe-Young – start-page: 1311 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib1070 article-title: Glutamatergic receptors in Parkinson’s disease contributor: fullname: Sampedro – volume: 3 start-page: 157 year: 2010 ident: 10.1016/j.pneurobio.2015.12.009_bib0750 article-title: Understanding the roles of the kynurenine pathway in multiple sclerosis progression publication-title: Int. J. Tryptophan. Res. doi: 10.4137/IJTR.S4294 contributor: fullname: Lim – volume: 230 start-page: 85 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0055 article-title: Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases–a mechanistic approach publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2014.01.039 contributor: fullname: Baltazar – volume: 55 start-page: 1327 year: 1990 ident: 10.1016/j.pneurobio.2015.12.009_bib0105 article-title: Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.1990.tb03143.x contributor: fullname: Beal – volume: 150 start-page: 305 year: 1998 ident: 10.1016/j.pneurobio.2015.12.009_bib1135 article-title: Chronic administration of quinolinic acid in the rat striatum causes spatial learning deficits in a radial arm water maze task publication-title: Exp. Neurol. doi: 10.1006/exnr.1998.6767 contributor: fullname: Shear – volume: 16 start-page: 157 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib1265 article-title: Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease publication-title: Nat. Cell Biol. doi: 10.1038/ncb2901 contributor: fullname: Tufi – volume: 40 start-page: 463 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib1100 article-title: Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder publication-title: Neuropsychopharmacology doi: 10.1038/npp.2014.194 contributor: fullname: Savitz – volume: 5 start-page: 137 year: 1996 ident: 10.1016/j.pneurobio.2015.12.009_bib0275 article-title: Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinson's disease mice model publication-title: Neurodegener. J. Neurodegenerative Disord. Neuroprot. Neuroregener. contributor: fullname: Czlonkowska – volume: 8 start-page: e72046 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0400 article-title: Rotenone directly induces BV2 cell activation via the p38 MAPK pathway publication-title: PLoS One doi: 10.1371/journal.pone.0072046 contributor: fullname: Gao – volume: 49 start-page: 29 year: 2004 ident: 10.1016/j.pneurobio.2015.12.009_bib0710 article-title: Characterization of striatal cultures with the effect of QUIN and NMDA publication-title: Neurosci. Res. doi: 10.1016/j.neures.2004.01.011 contributor: fullname: Kumar – volume: 12 start-page: 64 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib1295 article-title: Kynurenines in the CNS: recent advances and new questions publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd3793 contributor: fullname: Vecsei – volume: 63 start-page: 1702 year: 2004 ident: 10.1016/j.pneurobio.2015.12.009_bib0425 article-title: A presenilin 1 R278I mutation presenting with language impairment publication-title: Neurology doi: 10.1212/01.WNL.0000143060.98164.1A contributor: fullname: Godbolt – volume: 9 start-page: 32 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib0590 article-title: Inflammation in Parkinson's disease: role of glucocorticoids publication-title: Front. Neuroanat. doi: 10.3389/fnana.2015.00032 contributor: fullname: Herrero – volume: 119 start-page: 1717 year: 1996 ident: 10.1016/j.pneurobio.2015.12.009_bib0555 article-title: Subthalamotomy in Parkinsonian monkeys: behavioural and biochemical publication-title: Brain doi: 10.1093/brain/119.5.1717 contributor: fullname: Guridi – volume: 2012 start-page: 401264 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0970 article-title: Oxidative stress and microglial cells in Parkinson's disease publication-title: Mediators Inflamm. doi: 10.1155/2012/401264 contributor: fullname: Peterson – volume: 70 start-page: 4259 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0290 article-title: The role of inflammation in sporadic and familial Parkinson's disease publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-013-1352-y contributor: fullname: Deleidi – volume: 118 start-page: 816 year: 2010 ident: 10.1016/j.pneurobio.2015.12.009_bib0240 article-title: Characterization of the kynurenine pathway in NSC-34 cell line: implications for amyotrophic lateral sclerosis publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2010.07159.x contributor: fullname: Chen – volume: 277 start-page: 28572 year: 2002 ident: 10.1016/j.pneurobio.2015.12.009_bib0615 article-title: 2002. Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome publication-title: J. Biol. Chem. doi: 10.1074/jbc.M200666200 contributor: fullname: Hyun – volume: 38 start-page: 85 year: 1983 ident: 10.1016/j.pneurobio.2015.12.009_bib1130 article-title: Differential vulnerability of central neurons of the rat to quinolinic acid publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(83)90115-5 contributor: fullname: Schwarcz – volume: 398 start-page: 135 year: 1996 ident: 10.1016/j.pneurobio.2015.12.009_bib0805 article-title: Immunobiology of picolinic acid publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-1-4613-0381-7_22 contributor: fullname: Melillo – volume: 38 start-page: 743 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0335 article-title: Connecting inflammation with glutamate agonism in suicidality publication-title: Neuropsychopharmacology doi: 10.1038/npp.2012.248 contributor: fullname: Erhardt – volume: 112 start-page: 127 year: 2006 ident: 10.1016/j.pneurobio.2015.12.009_bib0680 article-title: Effect of 6-hydroxydopamine treatment on kynurenine aminotransferase-I (KAT-I) immunoreactivity of neurons and glial cells in the rat substantia nigra publication-title: Acta Neuropathol. (Berl.) doi: 10.1007/s00401-006-0086-4 contributor: fullname: Knyihar-Csillik – volume: 185 start-page: 3190 issue: 6 year: 2010 ident: 10.1016/j.pneurobio.2015.12.009_bib0825 article-title: An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells publication-title: J. Immunol. doi: 10.4049/jimmunol.0903670 contributor: fullname: Mezrich – volume: 279 start-page: 1356 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0550 article-title: Quinolinic acid the inescapable neurotoxin publication-title: FEBS J. doi: 10.1111/j.1742-4658.2012.08485.x contributor: fullname: Guillemin – volume: 98 start-page: 207 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib1320 article-title: Kinases and kinase signaling pathways: potential therapeutic targets in Parkinson's disease publication-title: Prog. Neurobiol. doi: 10.1016/j.pneurobio.2012.06.003 contributor: fullname: Wang – volume: 41 start-page: 926 issue: 7 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib0405 article-title: Purine metabolism gene deregulation in Parkinson’s disease publication-title: Neuropathol. Appl. Neurobiol. doi: 10.1111/nan.12221 contributor: fullname: Garcia-Esparcia – volume: 30 start-page: 233 year: 1997 ident: 10.1016/j.pneurobio.2015.12.009_bib1190 article-title: The effect of quinolinate on rat brain lipid peroxidation is dependent on iron publication-title: Neurochem. Int. doi: 10.1016/S0197-0186(97)90002-4 contributor: fullname: Stipek – volume: 8 start-page: 231 year: 2007 ident: 10.1016/j.pneurobio.2015.12.009_bib0300 article-title: A de novo SPAST mutation leading to somatic mosaicism is associated with a later age at onset in HSP publication-title: Neurogenetics doi: 10.1007/s10048-007-0090-4 contributor: fullname: Depienne – volume: 56 start-page: 148 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0310 article-title: Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia publication-title: Mol. Cell. Neurosci. doi: 10.1016/j.mcn.2013.04.007 contributor: fullname: Downer – volume: 28 start-page: 1057 year: 2010 ident: 10.1016/j.pneurobio.2015.12.009_bib1005 article-title: Epigenetic modifications and human disease publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1685 contributor: fullname: Portela – volume: 75 start-page: 2427 year: 2000 ident: 10.1016/j.pneurobio.2015.12.009_bib1270 article-title: Kynurenine 3-hydroxylase inhibition in rats: effects on extracellular kynurenic acid concentration and N-methyl-D-aspartate-induced depolarisation in the striatum publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2000.0752427.x contributor: fullname: Urenjak – volume: 586 start-page: 156 year: 2008 ident: 10.1016/j.pneurobio.2015.12.009_bib0565 article-title: Effects of the kynurenine 3-hydroxylase inhibitor Ro 61–8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2008.02.052 contributor: fullname: Hamann – volume: 54 start-page: 345 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib1000 article-title: Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs) publication-title: Angew. Chem. doi: 10.1002/anie.201408776 contributor: fullname: Pomplun – volume: 384 start-page: 545 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib1105 article-title: Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives publication-title: Lancet doi: 10.1016/S0140-6736(14)61010-2 contributor: fullname: Schapira – volume: 7 start-page: 103 year: 2005 ident: 10.1016/j.pneurobio.2015.12.009_bib0520 article-title: Involvement of quinolinic acid in AIDS dementia complex publication-title: Neurotox. Res. doi: 10.1007/BF03033781 contributor: fullname: Guillemin – volume: 69 start-page: 1629 year: 1997 ident: 10.1016/j.pneurobio.2015.12.009_bib0145 article-title: Energetic dysfunction in quinolinic acid-lesioned rat striatum publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.1997.69041629.x contributor: fullname: Bordelon – volume: 8 start-page: 475 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib0645 article-title: Glutamate receptors as therapeutic targets for Parkinson's disease publication-title: CNS Neurol. Disord. Drug Targets doi: 10.2174/187152709789824606 contributor: fullname: Johnson – volume: 4 start-page: e6344 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib1025 article-title: The excitotoxin quinolinic acid induces tau phosphorylation in human neurons publication-title: PLoS One doi: 10.1371/journal.pone.0006344 contributor: fullname: Rahman – volume: 85 start-page: 845 year: 2007 ident: 10.1016/j.pneurobio.2015.12.009_bib0225 article-title: Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications publication-title: J. Neurosci. Res. doi: 10.1002/jnr.21183 contributor: fullname: Ceresoli-Borroni – volume: 7 start-page: 199 year: 2002 ident: 10.1016/j.pneurobio.2015.12.009_bib0485 article-title: Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease publication-title: Redox Rep. doi: 10.1179/135100002125000550 contributor: fullname: Guillemin – volume: 42 start-page: 1702 year: 1992 ident: 10.1016/j.pneurobio.2015.12.009_bib0915 article-title: Kynurenine pathway abnormalities in Parkinson's disease publication-title: Neurology doi: 10.1212/WNL.42.9.1702 contributor: fullname: Ogawa – volume: 390 start-page: 267 year: 2000 ident: 10.1016/j.pneurobio.2015.12.009_bib1345 article-title: Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus publication-title: Eur. J. Pharmacol. doi: 10.1016/S0014-2999(00)00024-8 contributor: fullname: Wu – volume: 321 start-page: 168 year: 1986 ident: 10.1016/j.pneurobio.2015.12.009_bib0100 article-title: Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid publication-title: Nature doi: 10.1038/321168a0 contributor: fullname: Beal – volume: 36 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib0885 article-title: NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2014.07.028 contributor: fullname: Nalls – volume: 6 start-page: 398 year: 2007 ident: 10.1016/j.pneurobio.2015.12.009_bib0945 article-title: Kynurenine pathway and disease: an overview publication-title: CNS Neurol. Disord. Drug Targets doi: 10.2174/187152707783399229 contributor: fullname: Perez-De La Cruz – volume: 53 start-page: 415 year: 2000 ident: 10.1016/j.pneurobio.2015.12.009_bib1170 article-title: Quinolinic acid enhances permeability of rat brain microvessels to plasma albumin publication-title: Brain Res. Bull. doi: 10.1016/S0361-9230(00)00368-3 contributor: fullname: St'astny – volume: 199 start-page: 210 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib0950 article-title: Targeting oxidative/nitrergic stress ameliorates motor impairment: and attenuates synaptic mitochondrial dysfunction and lipid peroxidation in two models of Huntington's disease publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2008.11.037 contributor: fullname: Perez-De La Cruz – volume: 20 start-page: 792 year: 2005 ident: 10.1016/j.pneurobio.2015.12.009_bib1065 article-title: Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in Parkinsonian monkeys publication-title: Mov. Disord. doi: 10.1002/mds.20596 contributor: fullname: Samadi – volume: 31 start-page: 2313 year: 2001 ident: 10.1016/j.pneurobio.2015.12.009_bib0380 article-title: Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism publication-title: Eur. J. Immunol. doi: 10.1002/1521-4141(200108)31:8<2313::AID-IMMU2313>3.0.CO;2-S contributor: fullname: Fujigaki – volume: 13 start-page: 137 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0045 article-title: TRYCAT pathways link peripheral inflammation nicotine somatization and depression in the etiology and course of parkinson's disease publication-title: CNS Neurol. Disord. Drug Targets doi: 10.2174/18715273113129990082 contributor: fullname: Anderson – volume: 261 start-page: 60 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0080 article-title: Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2013.05.001 contributor: fullname: Barcia – volume: 447 start-page: 285 year: 2002 ident: 10.1016/j.pneurobio.2015.12.009_bib1195 article-title: The pharmacological manipulation of glutamate receptors and neuroprotection publication-title: Eur. J. Pharmacol. doi: 10.1016/S0014-2999(02)01851-4 contributor: fullname: Stone – volume: 61 start-page: 2061 year: 1993 ident: 10.1016/j.pneurobio.2015.12.009_bib1060 article-title: Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.1993.tb07443.x contributor: fullname: Saito – start-page: 323 year: 2007 ident: 10.1016/j.pneurobio.2015.12.009_bib1030 article-title: Kynurenines, redox disturbances and neurodegeneration in multiple sclerosis publication-title: J. Neural Transm. Suppl. contributor: fullname: Rajda – volume: 29 start-page: 873 issue: 3 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0180 article-title: Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons publication-title: Metab. Brain Dis. doi: 10.1007/s11011-014-9557-9 contributor: fullname: Braidy – volume: 126 start-page: 899 year: 2004 ident: 10.1016/j.pneurobio.2015.12.009_bib0675 article-title: Decreased expression of kynurenine aminotransferase-I (KAT-I) in the substantia nigra of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment publication-title: Neuroscience doi: 10.1016/j.neuroscience.2004.04.043 contributor: fullname: Knyihar-Csillik – volume: 34 start-page: 445 year: 2001 ident: 10.1016/j.pneurobio.2015.12.009_bib0995 article-title: Quinolinic acid-iron(ii) complexes: slow autoxidation: but enhanced hydroxyl radical production in the fenton reaction publication-title: Free Radic. Res. doi: 10.1080/10715760100300391 contributor: fullname: Platenik – volume: 672 start-page: 153 year: 1995 ident: 10.1016/j.pneurobio.2015.12.009_bib1300 article-title: Intrastriatal quinolinic acid injections protect against 6-hydroxydopamine-induced lesions of the dopaminergic nigrostriatal system publication-title: Brain Res. doi: 10.1016/0006-8993(94)01368-R contributor: fullname: Venero – volume: 77 start-page: 1310 year: 2001 ident: 10.1016/j.pneurobio.2015.12.009_bib0250 article-title: Similarities and differences in the neuronal death processes activated by 3OH-kynurenine and quinolinic acid publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2001.00335.x contributor: fullname: Chiarugi – volume: 39 start-page: 7266 year: 2000 ident: 10.1016/j.pneurobio.2015.12.009_bib0435 article-title: 3- hydroxykynurenine and 3-Hydroxyanthranilic acid generate hydrogen peroxide and promote Œ ± −Crystallin cross-Linking by metal ion reduction, Ć publication-title: Biochemistry doi: 10.1021/bi992997s contributor: fullname: Goldstein – volume: 251 start-page: 893 year: 1988 ident: 10.1016/j.pneurobio.2015.12.009_bib0620 article-title: Superoxide-Dismutase enhances the formation of hydroxyl radicals in the reaction of 3-Hydroxyanthranilic acid with molecular-Oxygen publication-title: Biochem. J. doi: 10.1042/bj2510893 contributor: fullname: Iwahashi – volume: 3 start-page: e379 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0075 article-title: IFN-gamma signaling, with the synergistic contribution of TNF-alpha, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease publication-title: Cell Death Dis. doi: 10.1038/cddis.2012.123 contributor: fullname: Barcia – volume: 68 start-page: 665 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib1340 article-title: Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes publication-title: Arch. Gen. Psychiatry doi: 10.1001/archgenpsychiatry.2011.71 contributor: fullname: Wonodi – volume: 22 start-page: 1331 year: 1983 ident: 10.1016/j.pneurobio.2015.12.009_bib0370 article-title: On the excitotoxic properties of quinolinic acid 2, 3-piperidine dicarboxylic acids and structurally related compounds publication-title: Neuropharmacology doi: 10.1016/0028-3908(83)90221-6 contributor: fullname: Foster – volume: 8 start-page: 94 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib1180 article-title: Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? publication-title: J. Neuroinflammation doi: 10.1186/1742-2094-8-94 contributor: fullname: Steiner – volume: 81 start-page: 247 year: 2003 ident: 10.1016/j.pneurobio.2015.12.009_bib0835 article-title: Tryptophan and the immune response publication-title: Immunol. Cell Biol. doi: 10.1046/j.1440-1711.2003.t01-1-01177.x contributor: fullname: Moffett – volume: 167 start-page: 196 year: 2001 ident: 10.1016/j.pneurobio.2015.12.009_bib0920 article-title: The role of group I and group II metabotropic glutamate receptors in modulation of striatal NMDA and quinolinic acid toxicity publication-title: Exp. Neurol. doi: 10.1006/exnr.2000.7542 contributor: fullname: Orlando – volume: 5 start-page: 1 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib0025 article-title: Role of alpha-synuclein in inducing innate and adaptive immunity in Parkinson disease publication-title: J. Parkinson's Disease doi: 10.3233/JPD-140491 contributor: fullname: Allen Reish – volume: 2013 start-page: 104024 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0780 article-title: Quinolinic acid: an endogenous neurotoxin with multiple targets publication-title: Oxid. Med. Cell. Longevity doi: 10.1155/2013/104024 contributor: fullname: Lugo-Huitron – volume: 1792 start-page: 714 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib0630 article-title: Viral parkinsonism publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2008.08.001 contributor: fullname: Jang – volume: 144 start-page: 287 year: 1997 ident: 10.1016/j.pneurobio.2015.12.009_bib0840 article-title: Quinolinate immunoreactivity in experimental rat brain tumors is present in macrophages but not in astrocytes publication-title: Exp. Neurol. doi: 10.1006/exnr.1996.6365 contributor: fullname: Moffett – volume: 277 start-page: 368 year: 2010 ident: 10.1016/j.pneurobio.2015.12.009_bib0175 article-title: Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons publication-title: FEBS J. doi: 10.1111/j.1742-4658.2009.07487.x contributor: fullname: Braidy – volume: 10 start-page: e0115439 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib0705 article-title: Biochemical, histopathological and morphological profiling of a rat model of early immune stimulation: relation to psychopathology publication-title: PLoS One doi: 10.1371/journal.pone.0115439 contributor: fullname: Kubesova – volume: 159 start-page: 51 year: 1993 ident: 10.1016/j.pneurobio.2015.12.009_bib1085 article-title: MK-801 an N-methyl-D-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(93)90796-N contributor: fullname: Santamaria – volume: 135 start-page: 1435 year: 2002 ident: 10.1016/j.pneurobio.2015.12.009_bib0120 article-title: Enhanced neuronal damage by co-administration of quinolinic acid and free radicals: and protection by adenosine A2A receptor antagonists publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0704613 contributor: fullname: Behan – volume: 327 start-page: 123 year: 2002 ident: 10.1016/j.pneurobio.2015.12.009_bib0215 article-title: Apoptosis of oligodendrocytes in secondary cultures from neonatal rat brains publication-title: Neurosci. Lett. doi: 10.1016/S0304-3940(02)00392-0 contributor: fullname: Cammer – volume: 18 start-page: 535 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0470 article-title: Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis publication-title: Cell Stress Chaperones doi: 10.1007/s12192-013-0426-y contributor: fullname: Groves – volume: 8 start-page: 159 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib1035 article-title: Alpha-synuclein spreading in Parkinson's disease publication-title: Front. Neuroanat. doi: 10.3389/fnana.2014.00159 contributor: fullname: Recasens – volume: 26 start-page: 578 year: 2003 ident: 10.1016/j.pneurobio.2015.12.009_bib1370 article-title: Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics publication-title: Trends Neurosci. doi: 10.1016/j.tins.2003.08.009 contributor: fullname: Zecca – volume: 239 start-page: 31 year: 2005 ident: 10.1016/j.pneurobio.2015.12.009_bib0585 article-title: Kynurenine metabolism in plasma and in red blood cells in Parkinson's disease publication-title: J. Neurol. Sci. doi: 10.1016/j.jns.2005.07.006 contributor: fullname: Hartai – volume: 35 start-page: 421 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0765 article-title: Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2013.08.015 contributor: fullname: Lu – volume: 20 start-page: 5507 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib1275 article-title: Mitochondrial biogenesis: pharmacological approaches publication-title: Curr. Pharm. Des. doi: 10.2174/138161282035140911142118 contributor: fullname: Valero – volume: 6 start-page: 36 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib1255 article-title: Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease publication-title: J. Neuroinflamm. doi: 10.1186/1742-2094-6-36 contributor: fullname: Ting – volume: 12 start-page: 359 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib0260 article-title: Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3039 contributor: fullname: Collier – volume: 1 start-page: 1 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib0230 article-title: Kynurenine pathway metabolites in humans: disease and healthy states publication-title: Int. J. Trypto. Res. contributor: fullname: Chen – volume: 16 start-page: 728 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0395 article-title: Organelle-specific initiation of cell death publication-title: Nat. Cell Biol. doi: 10.1038/ncb3005 contributor: fullname: Galluzzi – volume: 138 start-page: 1454 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib0460 article-title: Parkinson's disease dementia: a neural networks perspective publication-title: Brain doi: 10.1093/brain/awv104 contributor: fullname: Gratwicke – volume: 43 start-page: 110 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib0095 article-title: A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2014.07.012 contributor: fullname: Bay-Richter – volume: 36 start-page: 1449 issue: 8 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib1285 article-title: Cerebral cortex, hippocampus, striatum and cerebellum show differential susceptibility to quinolinic acid-induced oxidative stress publication-title: Neurol. Sci. doi: 10.1007/s10072-015-2180-7 contributor: fullname: Vandresen-Filho – volume: 38 start-page: 1609 issue: 9 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib1315 article-title: NMDA receptor blockade by ketamine abrogates lipopolysaccharide-Induced depressive-Like behavior in C57BL/6J mice publication-title: Neuropsychopharmacology doi: 10.1038/npp.2013.71 contributor: fullname: Walker – volume: 47 start-page: PL91 year: 1990 ident: 10.1016/j.pneurobio.2015.12.009_bib0450 article-title: Injection of excitatory amino acid antagonists into the medial pallidal segment of a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated primate reverses motor symptoms of parkinsonism publication-title: Life Sci. doi: 10.1016/0024-3205(90)90376-3 contributor: fullname: Graham – volume: 73 start-page: 185 year: 1996 ident: 10.1016/j.pneurobio.2015.12.009_bib0875 article-title: Antioxidant treatment protects striatal neurons against excitotoxic insults publication-title: Neuroscience doi: 10.1016/0306-4522(96)00034-6 contributor: fullname: Nakao – volume: 29 start-page: 1060 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib1020 article-title: Analysis of Parkinson's disease brain-derived DNA for alpha-synuclein coding somatic mutations publication-title: Mov. Disord. doi: 10.1002/mds.25883 contributor: fullname: Proukakis – volume: 30 start-page: 333 year: 1988 ident: 10.1016/j.pneurobio.2015.12.009_bib1200 article-title: NMDA receptors and ligands in the vertebrate CNS publication-title: Prog. Neurobiol. doi: 10.1016/0301-0082(88)90027-5 contributor: fullname: Stone – volume: 27 start-page: 12884 year: 2007 ident: 10.1016/j.pneurobio.2015.12.009_bib0545 article-title: Characterization of the kynurenine pathway in human neurons publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4101-07.2007 contributor: fullname: Guillemin – volume: 76 start-page: 139 year: 2001 ident: 10.1016/j.pneurobio.2015.12.009_bib0990 article-title: N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2001.00057.x contributor: fullname: Pittaluga – volume: 106 start-page: 14063 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib0625 article-title: Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0900096106 contributor: fullname: Jang – volume: 105 start-page: 45 year: 1989 ident: 10.1016/j.pneurobio.2015.12.009_bib1075 article-title: The quinolinic acid model of Huntington's disease: locomotor abnormalities publication-title: Exp. Neurol. doi: 10.1016/0014-4886(89)90170-2 contributor: fullname: Sanberg – volume: 118 year: 2001 ident: 10.1016/j.pneurobio.2015.12.009_bib0500 article-title: Bamyloid peptide 1–42 induces human macrophages to produce the neurotoxin quinolinic acid publication-title: J. Neuroimmunol. contributor: fullname: Guillemin – volume: 38 start-page: 85 year: 1983 ident: 10.1016/j.pneurobio.2015.12.009_bib1125 article-title: Differential vulnerability of central neurons of the rat to quinolinic acid publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(83)90115-5 contributor: fullname: Schwarcz – volume: 128 start-page: 1754 year: 1999 ident: 10.1016/j.pneurobio.2015.12.009_bib0130 article-title: Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0702940 contributor: fullname: Behan – volume: 94 start-page: 429 year: 1992 ident: 10.1016/j.pneurobio.2015.12.009_bib0365 article-title: Astrocytes and parkinson's disease publication-title: Prog. Brain Res. doi: 10.1016/S0079-6123(08)61770-7 contributor: fullname: Forno – volume: 511 start-page: 184 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0140 article-title: Aryl hydrocarbon receptor control of a disease tolerance defence pathway publication-title: Nature doi: 10.1038/nature13323 contributor: fullname: Bessede – volume: 7 start-page: 15 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0655 article-title: Imbalanced kynurenine pathway in schizophrenia publication-title: Int. J. Tryptophan. Res. doi: 10.4137/IJTR.S16800 contributor: fullname: Kegel – volume: 28 start-page: 8 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0665 article-title: Parkinson's disease: evidence for environmental risk factors publication-title: Mov. Disord. doi: 10.1002/mds.25150 contributor: fullname: Kieburtz – volume: 13 start-page: 501 year: 2008 ident: 10.1016/j.pneurobio.2015.12.009_bib0800 article-title: Inflammation glutamate, and glia in depression: a literature review publication-title: CNS Spectr. doi: 10.1017/S1092852900016734 contributor: fullname: McNally – volume: 35 start-page: 847 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0975 article-title: Management of the aging risk factor for Parkinson's disease publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2013.10.073 contributor: fullname: Phillipson – volume: 24 start-page: 296 year: 2006 ident: 10.1016/j.pneurobio.2015.12.009_bib0355 article-title: Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2006.07.005 contributor: fullname: Fernandez-Gomez – volume: 48 start-page: 273 year: 1984 ident: 10.1016/j.pneurobio.2015.12.009_bib0375 article-title: Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(84)90050-8 contributor: fullname: Foster – volume: 14 start-page: 19 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib1040 article-title: Ageing and Parkinson's disease: why is advancing age the biggest risk factor? publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2014.01.004 contributor: fullname: Reeve – volume: 12 start-page: 871 year: 2001 ident: 10.1016/j.pneurobio.2015.12.009_bib1090 article-title: Quinolinic acid induces oxidative stress in rat brain synaptosomes publication-title: Neuroreport doi: 10.1097/00001756-200103260-00049 contributor: fullname: Santamaria – volume: 199 start-page: 384 year: 2006 ident: 10.1016/j.pneurobio.2015.12.009_bib1290 article-title: Transplanted adult neural progenitor cells survive: differentiate and reduce motor function impairment in a rodent model of Huntington's disease publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2006.01.034 contributor: fullname: Vazey – volume: 60 start-page: 288 year: 1993 ident: 10.1016/j.pneurobio.2015.12.009_bib1110 article-title: Mitochondrial complex I deficiency in Parkinson's disease publication-title: Adv. Neurol. contributor: fullname: Schapira – volume: 481 start-page: 356 year: 1989 ident: 10.1016/j.pneurobio.2015.12.009_bib1375 article-title: Effect of MK-801 kynurenate, glycine, dextrorphan and 4-acetylpyridine on striatal toxicity of quinolinate publication-title: Brain Res. doi: 10.1016/0006-8993(89)90814-7 contributor: fullname: Zhu – volume: 49 start-page: 771 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0040 article-title: Neurodegeneration in Parkinson's disease: interactions of oxidative stress: tryptophan catabolites and depression with mitochondria and sirtuins publication-title: Mol. Neurobiol. doi: 10.1007/s12035-013-8554-z contributor: fullname: Anderson – volume: 28 start-page: 445 year: 1996 ident: 10.1016/j.pneurobio.2015.12.009_bib0285 article-title: The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits publication-title: Neurochem. Int. doi: 10.1016/0197-0186(95)00091-7 contributor: fullname: de Carvalho – volume: 112 start-page: 93 year: 2005 ident: 10.1016/j.pneurobio.2015.12.009_bib0575 article-title: Kynurenine metabolism in multiple sclerosis publication-title: Acta Neurol. Scand. doi: 10.1111/j.1600-0404.2005.00442.x contributor: fullname: Hartai – volume: 100 start-page: 347 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib1365 article-title: Acetyl-L-carnitine and alpha-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/j.pbb.2011.09.002 contributor: fullname: Zaitone – volume: 2 start-page: 1 year: 2009 ident: 10.1016/j.pneurobio.2015.12.009_bib0235 article-title: Kynurenine pathway metalbolites in humans: disease and healthy states publication-title: IJTR doi: 10.4137/IJTR.S2097 contributor: fullname: Chen – volume: 26 start-page: 6 year: 2011 ident: 10.1016/j.pneurobio.2015.12.009_bib0560 article-title: Glia: initiators and progressors of pathology in Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.23455 contributor: fullname: Halliday – volume: 28 start-page: 1200 issue: 6 year: 2007 ident: 10.1016/j.pneurobio.2015.12.009_bib0015 article-title: Time-related changes in constitutive and inducible nitric oxide synthases in the rat striatum in a model of Huntington's disease publication-title: Neurotoxicology doi: 10.1016/j.neuro.2007.07.010 contributor: fullname: Aguilera – volume: 119 start-page: 275 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib1360 article-title: Kynurenines in Parkinson's disease: therapeutic perspectives publication-title: J. Neural Transm. doi: 10.1007/s00702-011-0697-3 contributor: fullname: Zadori – volume: 119 start-page: 151 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0295 article-title: A novel kynurenic acid analog (SZR104) inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological study: related to kynurenine publication-title: J. Neural Transm. doi: 10.1007/s00702-011-0755-x contributor: fullname: Demeter – volume: 51 start-page: 327 year: 2006 ident: 10.1016/j.pneurobio.2015.12.009_bib1160 article-title: Midbrain neuronal cultures from parkin mutant mice are resistant to nitric oxide-induced toxicity publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2006.03.027 contributor: fullname: Solano – volume: 9 start-page: e87877 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0760 article-title: Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production publication-title: PLoS One doi: 10.1371/journal.pone.0087877 contributor: fullname: Lowe – volume: 10 start-page: 15 year: 2004 ident: 10.1016/j.pneurobio.2015.12.009_bib0865 article-title: IDO and tolerance to tumors publication-title: Trends Mol. Med. doi: 10.1016/j.molmed.2003.11.003 contributor: fullname: Munn – volume: 8 start-page: 211 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0200 article-title: Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease publication-title: Front. Cell. Neurosci. doi: 10.3389/fncel.2014.00211 contributor: fullname: Cabezas – volume: 2 start-page: 953 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0020 article-title: Discovery and verification of panels of T-lymphocyte proteins as biomarkers of Parkinson's disease publication-title: Scientific Rep. doi: 10.1038/srep00953 contributor: fullname: Alberio – volume: 71 start-page: 258 year: 2012 ident: 10.1016/j.pneurobio.2015.12.009_bib0190 article-title: Nigral pathology and Parkinsonian signs in elders without Parkinson disease publication-title: Ann. Neurol. doi: 10.1002/ana.22588 contributor: fullname: Buchman – volume: 76 start-page: 335 year: 1997 ident: 10.1016/j.pneurobio.2015.12.009_bib0725 article-title: Reevaluation of the functional anatomy of the basal ganglia in normal and Parkinsonian states publication-title: Neuroscience doi: 10.1016/S0306-4522(96)00409-5 contributor: fullname: Levy – volume: 49 start-page: 28 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib0910 article-title: The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson's disease: focus on astrocytes publication-title: Mol. Neurobiol. doi: 10.1007/s12035-013-8483-x contributor: fullname: Niranjan – volume: 15 start-page: 765 year: 1997 ident: 10.1016/j.pneurobio.2015.12.009_bib1310 article-title: Consequences of nigrostriatal denervation on the functioning of the basal ganglia in human and non-human primates: an in situ hybridization study of cytochrome oxidase subunit I mRNA publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.17-02-00765.1997 contributor: fullname: Vila – volume: 36 start-page: 1559 year: 2015 ident: 10.1016/j.pneurobio.2015.12.009_bib1280 article-title: FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an alpha-synuclein-based rat model for Parkinson's disease publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2015.01.014 contributor: fullname: Van der Perren – volume: 161 start-page: 271 year: 2010 ident: 10.1016/j.pneurobio.2015.12.009_bib0315 article-title: Therapeutic potential of targeting group III metabotropic glutamate receptors in the treatment of Parkinson's disease publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2010.00882.x contributor: fullname: Duty – volume: 186 start-page: 161 year: 2008 ident: 10.1016/j.pneurobio.2015.12.009_bib0465 article-title: Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in Parkinsonian monkeys publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2007.08.007 contributor: fullname: Gregoire – volume: 9 start-page: 13 year: 2013 ident: 10.1016/j.pneurobio.2015.12.009_bib0430 article-title: 100 years of Lewy pathology publication-title: Nat. Rev. Neurol. doi: 10.1038/nrneurol.2012.242 contributor: fullname: Goedert – volume: 1304 start-page: 213 year: 2007 ident: 10.1016/j.pneurobio.2015.12.009_bib0745 article-title: Characterization of the kynurenine pathway in primary human oligodendrocytes publication-title: Int. Congress Series doi: 10.1016/j.ics.2007.07.011 contributor: fullname: Lim – volume: 11 start-page: 204 year: 2014 ident: 10.1016/j.pneurobio.2015.12.009_bib1225 article-title: Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies publication-title: J. Neuroinflammation doi: 10.1186/s12974-014-0204-5 contributor: fullname: Sundaram |
| SSID | ssj0006303 |
| Score | 2.5785682 |
| SecondaryResourceType | review_article |
| Snippet | Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of dopaminergic neurons and localized neuroinflammation occurring in the... |
| SourceID | crossref pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 76 |
| SubjectTerms | Animals Humans Kynurenine - immunology Kynurenine - metabolism Parkinson Disease - immunology Parkinson Disease - metabolism |
| Title | Involvement of the kynurenine pathway in the pathogenesis of Parkinson's disease |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27072742 |
| Volume | 155 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6V9MIFQcujQKs9VHDayq_14xiiPqhaFKEg9WZtdteQVrGj1giFX8_MPuxYLRL0YsVeZ6LMN5qdnSchhzLIMpEoyVSQaJZUuWQi5oJlaVBU6OZPFUZ0L7-kZ9-S8yt-1eeqmuqSdn4kfz9YV_IYVOEZ4IpVsv-BbEcUHsBnwBeugDBc_wnjzzUoF9Pwu_Wx_ps1Vv7WaDvisOFfYu0zGfG2-Y6qzbYgwXpnV_qV3Q0CNc5WnWLqFipCIGDaXrqGTV0Ojx3EPPkhFr2zFP3SJvgeonOanTZL66J2Azxk08ehPt2KhVfxqqN6jL4XZUzaiVFAdry390zAbufz4mBjsdo0z2KGR5iBuuV8Q2Ha4S_39Lh1KVwfrfzfwyQ8bhy3pptCu4HuamngjbIgw7hzv7F16YZ-6QnZjrKC8xHZHk--Xky7LTuFjXyQ_Pfg72LjaEdpYMUMziPGLpk9J8_cgYKOrXS8IFu63iG741q0zXJNP1CT4mtw2yXTDYGhTUVBLGgvMNQJDF3UZmVTYPDtTmA-3lEnLi_J7OR4NjljbqQGk3EYtyzNpQ4r9AnEVcE1nBdVwSOhU2zEL8F0ltjMCUw6EQaFjAA6lcZJCnc8z7WIX5FR3dT6DaGJVgqoJXEkqyQQOp9HRajA2AklvJrzPRJ4DpUr2zil9BmF12XH3xL5W4ZRCfzdI68tJ7sveHa__evKO_K0F733ZNTe_tT7YCa28wMH8h-Znmjw |
| link.rule.ids | 315,786,790,27955,27956 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Involvement+of+the+kynurenine+pathway+in+the+pathogenesis+of+Parkinson%27s+disease&rft.jtitle=Progress+in+neurobiology&rft.au=Lim%2C+Chai+K&rft.au=Fern%C3%A1ndez-Gomez%2C+Francisco+J&rft.au=Braidy%2C+Nady&rft.au=Estrada%2C+Cristina&rft.date=2017-08-01&rft.eissn=1873-5118&rft.volume=155&rft.spage=76&rft_id=info:doi/10.1016%2Fj.pneurobio.2015.12.009&rft_id=info%3Apmid%2F27072742&rft.externalDocID=27072742 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0301-0082&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0301-0082&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0301-0082&client=summon |