Functional and regulatory impact of chimeric RNAs in human normal and cancer cells

• Published in: Wiley interdisciplinary reviews. RNA p. e1777
• Main Authors: Mukherjee, Sumit, Mukherjee, Sunanda Biswas, Frenkel-Morgenstern, Milana
• Format: Journal Article
• Language: English
• Published: United States 01.09.2023
• Subjects: drug-resistance; precision medicine; cancer; chimeric RNA; sense-antisense chimeric RNA

Fusions of two genes can lead to the generation of chimeric RNAs, which may have a distinct functional role from their original molecules. Chimeric RNAs could encode novel functional proteins or serve as novel long noncoding RNAs (lncRNAs). The appearance of chimeric RNAs in a cell could help to gen...