Lipid-Encapsulated mRNAs Encoding Complex Fusion Proteins Potentiate Antitumor Immune Responses

• Published in: Cancer research (Chicago, Ill.) Vol. 84; no. 10; pp. 1550 - 1559
• Main Authors: Shuptrine, Casey W, Chen, Yuhui, Miriyala, Jayalakshmi, Lenz, Karen, Moffett, Danielle, Nguyen, Thuy-Ai, Michaux, Jenn, Campbell, Kristen, Smith, Connor, Morra, Marc, Rivera-Molina, Yisel, Murr, Noah, Cooper, Sarah, McGuire, Ashlyn, Makani, Vishruti, Oien, Nathan, Zugates, Jeffery T, de Silva, Suresh, Schreiber, Taylor H, de Picciotto, Seymour, Fromm, George
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 15.05.2024
• Subjects: Animals; Biological Agents & Therapies; Cancer Vaccines - administration & dosage; Cancer Vaccines - genetics; Cancer Vaccines - immunology; Carcinogenesis; Cell Line, Tumor; Female; Humans; Immunology; Immunotherapy; Lipids - chemistry; Mice; Mice, Inbred C57BL; Nanoparticles - chemistry; Priority Report; Receptors, Immunologic - genetics; Receptors, Immunologic - immunology; Recombinant Fusion Proteins - administration & dosage; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - immunology; RNA, Messenger - genetics

Lipid nanoparticle (LNP)-encapsulated mRNA has been used for in vivo production of several secreted protein classes, such as IgG, and has enabled the development of personalized vaccines in oncology. Establishing the feasibility of delivering complex multispecific modalities that require higher-orde...