Long-term analysis of adrenocorticotropic hormone monotherapy for infantile epileptic spasms syndrome with periventricular leukomalacia

• Published in: Seizure (London, England) Vol. 109; pp. 40 - 44
• Main Authors: Matsuura, Ryuki, Hamano, Shin-ichiro, Hirata, Yuko, Takeda, Rikako, Takeuchi, Hirokazu, Koichihara, Reiko, Kikuchi, Kenjiro, Oka, Akira
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2023
• Subjects: Adverse effect; Child; Epilepsy; Hypsarrhythmia; Infantile epileptic spasms syndrome; Prognosis; Prognosis; Infantile epileptic spasms syndrome; Epilepsy; EEG; PVL; ACTH; IQ; IVIG; Adverse effect; DQ; ID; Child; Hypsarrhythmia

•ACTH monotherapy outcomes assessed for infantile epileptic spasm syndrome and PVL.•A positive response was observed in seven of 12 patients (58.3%).•Epileptic discharge in the parieto-occipital region was associated with relapse.•PVL grade III was also associated with relapse.•Our results will help...