Spectroscopic measurements and terahertz imaging of the cornea using a rapid scanning terahertz time domain spectrometer
Spectroscopic measurements and terahertz imaging of the cornea are carried out by using a rapid scanning terahertz time domain spectroscopy（THz-TDS） system.A voice coil motor stage based optical delay line（VCM-ODL） is developed to provide a rather simple and robust structure with both the high scann...
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| Published in | Chinese physics B Vol. 25; no. 6; pp. 150 - 156 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
01.06.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-1056 2058-3834 1741-4199 |
| DOI | 10.1088/1674-1056/25/6/060702 |
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| Abstract | Spectroscopic measurements and terahertz imaging of the cornea are carried out by using a rapid scanning terahertz time domain spectroscopy（THz-TDS） system.A voice coil motor stage based optical delay line（VCM-ODL） is developed to provide a rather simple and robust structure with both the high scanning speed and the large delay length.The developed system is used for THz spectroscopic measurements and imaging of the corneal tissue with different amounts of water content,and the measurement results show the consistence with the reported results,in which the measurement time using VCM-ODL is a factor of 360 shorter than the traditional motorized optical delay line（MDL）.With reducing the water content a monotonic decrease of the complex permittivity of the cornea is observed.The two-term Debye relaxation model is employed to explain our experimental results,revealing that the fast relaxation time of a dehydrated cornea is much larger than that of a hydrated cornea and its dielectric behavior can be affected by the presence of the biological macromolecules.These results demonstrate that our THz spectrometer may be a promising candidate for tissue hydration sensing and practical application of THz technology. |
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| AbstractList | Spectroscopic measurements and terahertz imaging of the cornea are carried out by using a rapid scanning terahertz time domain spectroscopy (THz-TDS) system. A voice coil motor stage based optical delay line (VCM-ODL) is developed to provide a rather simple and robust structure with both the high scanning speed and the large delay length. The developed system is used for THz spectroscopic measurements and imaging of the corneal tissue with different amounts of water content, and the measurement results show the consistence with the reported results, in which the measurement time using VCM-ODL is a factor of 360 shorter than the traditional motorized optical delay line (MDL). With reducing the water content a monotonic decrease of the complex permittivity of the cornea is observed. The two-term Debye relaxation model is employed to explain our experimental results, revealing that the fast relaxation time of a dehydrated cornea is much larger than that of a hydrated cornea and its dielectric behavior can be affected by the presence of the biological macromolecules. These results demonstrate that our THz spectrometer may be a promising candidate for tissue hydration sensing and practical application of THz technology. Spectroscopic measurements and terahertz imaging of the cornea are carried out by using a rapid scanning terahertz time domain spectroscopy（THz-TDS） system.A voice coil motor stage based optical delay line（VCM-ODL） is developed to provide a rather simple and robust structure with both the high scanning speed and the large delay length.The developed system is used for THz spectroscopic measurements and imaging of the corneal tissue with different amounts of water content,and the measurement results show the consistence with the reported results,in which the measurement time using VCM-ODL is a factor of 360 shorter than the traditional motorized optical delay line（MDL）.With reducing the water content a monotonic decrease of the complex permittivity of the cornea is observed.The two-term Debye relaxation model is employed to explain our experimental results,revealing that the fast relaxation time of a dehydrated cornea is much larger than that of a hydrated cornea and its dielectric behavior can be affected by the presence of the biological macromolecules.These results demonstrate that our THz spectrometer may be a promising candidate for tissue hydration sensing and practical application of THz technology. |
| Author | 刘文权 鲁远甫 焦国华 陈险峰 周志盛 佘荣斌 李金瑛 陈四海 董玉明 吕建成 |
| AuthorAffiliation | Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China Biomedical Engineering Laboratory for Photoelectric Sensing Technology, Shenzhen 518055, China Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen 518055, China The Chinese University of Hong Kong, Shatin, Hong Kong, China School of Electronic Engineering, Bangor University, Bangor, Gwynedd LL57 1 UT, UK Department of Ophthalmology, Peking University Shenzhen Hospital, Shenzhen 518036, China |
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| CitedBy_id | crossref_primary_10_1016_j_saa_2021_120812 crossref_primary_10_3390_app9050917 crossref_primary_10_17116_oftalma202113703158 crossref_primary_10_1088_1674_1056_ad1e66 crossref_primary_10_1109_JSEN_2022_3162146 crossref_primary_10_1038_s41598_022_22033_2 crossref_primary_10_1109_TTHZ_2024_3368653 |
| Cites_doi | 10.1364/JOSAB.28.000592 10.1088/0031-9155/41/11/003 10.1117/1.3575168 10.1063/1.1688448 10.1063/1.2135869 10.1038/srep04988 10.1364/OE.21.021299 10.1117/12.724884 10.1109/JSTQE.2010.2047635 10.1109/JQE.1980.1070606 10.1007/s10762-013-9972-8 10.1364/OE.18.026163 10.1007/s10762-014-0085-9 10.1063/1.2995763 10.1002/lpor.v5.1 10.1063/1.2008379 10.1109/TPS.2010.2049590 10.1016/S0167-7322(02)00093-4 10.1016/0009-2614(95)00543-D 10.1364/OL.29.002082 10.1109/JSEN.2010.2088387 10.1088/0031-9155/28/1/004 10.1109/TTHZ.2015.2392619 10.1103/PhysRevLett.82.2888 10.1117/1.JBO.17.9.097008 10.1016/j.optcom.2015.09.107 10.1063/1.2151267 10.2528/PIER12112510 10.1038/srep02910 10.1109/TBME.2013.2237908 10.1109/TTHZ.2015.2392628 10.1063/1.2437764 10.3109/02713688809031816 10.1007/s10762-011-9865-7 |
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| Notes | Wen-Quan Liu,Yuan-Fu Lu,Guo-Hua Jiao,Xian-Feng Chen,Zhi-Sheng Zhou,Rong-Bin She,Jin-Ying Li,Si-Hai Chen,Yu-Ming Dong,Jian-Cheng Lv terahertz;rapid scanning terahertz time domain spectrometer;tissue diagnostics;terahertz imaging Spectroscopic measurements and terahertz imaging of the cornea are carried out by using a rapid scanning terahertz time domain spectroscopy（THz-TDS） system.A voice coil motor stage based optical delay line（VCM-ODL） is developed to provide a rather simple and robust structure with both the high scanning speed and the large delay length.The developed system is used for THz spectroscopic measurements and imaging of the corneal tissue with different amounts of water content,and the measurement results show the consistence with the reported results,in which the measurement time using VCM-ODL is a factor of 360 shorter than the traditional motorized optical delay line（MDL）.With reducing the water content a monotonic decrease of the complex permittivity of the cornea is observed.The two-term Debye relaxation model is employed to explain our experimental results,revealing that the fast relaxation time of a dehydrated cornea is much larger than that of a hydrated cornea and its dielectric behavior can be affected by the presence of the biological macromolecules.These results demonstrate that our THz spectrometer may be a promising candidate for tissue hydration sensing and practical application of THz technology. 11-5639/O4 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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| References | 22 23 24 25 26 Jin W J (8) 2013; 22 27 28 29 Zhou Q L (9) 2011; 20 30 31 10 33 12 34 13 35 14 36 15 37 16 17 18 19 1 2 3 Gabriel S (32) 1996; 41 4 5 6 Gabriel C (11) 1983; 28 Dong C (7) 2014; 23 20 21 |
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| Snippet | Spectroscopic measurements and terahertz imaging of the cornea are carried out by using a rapid scanning terahertz time domain spectroscopy（THz-TDS） system.A... Spectroscopic measurements and terahertz imaging of the cornea are carried out by using a rapid scanning terahertz time domain spectroscopy (THz-TDS) system. A... |
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| SubjectTerms | Cornea Imaging Moisture content Scanning Spectrometers Spectroscopic analysis Spectroscopy THz-TDS Time domain 光纤延迟线 光谱仪 光谱测量 太赫兹成像 太赫兹时域光谱技术 快速扫描 角膜 |
| Title | Spectroscopic measurements and terahertz imaging of the cornea using a rapid scanning terahertz time domain spectrometer |
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