Benzo[a]pyrene exposure and incident risks of digestive system cancers: Insights from nested case-control studies and adverse outcome pathway network analysis

• Published in: Journal of hazardous materials Vol. 487; p. 137159
• Main Authors: Zhao, Hui, Xiao, Yang, Fu, Ye, Guan, Xin, Fu, Ming, Wang, Chenming, Zhou, Yuhan, Hong, Shiru, You, Yingqian, Wang, Yuxi, Chen, Shengli, Zhang, Yichi, Bai, Yansen, Guo, Huan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.04.2025
• Subjects: Adult; Adverse outcome pathway; Adverse Outcome Pathways; Aged; apoptosis; Benzo(a)pyrene - toxicity; Benzo[a]pyrene; carcinogenesis; carcinogenicity; carcinogens; Carcinogens - toxicity; Case-Control Studies; cell proliferation; digestive system; Digestive system cancer; Digestive System Neoplasms - chemically induced; Digestive System Neoplasms - epidemiology; Female; Humans; lung neoplasms; Male; Middle Aged; Nested case-control study; Benzo[a]pyrene; Digestive system cancer; Nested case-control study; Adverse outcome pathway

Benzo[a]pyrene (B[a]P) is a recognized carcinogen for lung cancer, but its associations with digestive system cancers (DSCs) remain unclear and the common carcinogenic mechanisms are not fully understood. We conducted five nested case-control studies within the Dongfeng-Tongji cohort, including esop...