Transcriptomic analysis of digitoxin: Synergy with doxorubicin in HER2-overexpressing MDA-MB-453 breast cancer cells - Einbond, Linda Saxe; Huang, Kunhui; Balick, Michael; Ma, Hongbao; Gharbaran, Rajendra; Redenti, Stephen; Wu, Hsan-au (Biochimie, 2025)
Keywords: Bioelectricity; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cardiac glycosides; Cell Line, Tumor; Digitoxin - chemistry; Digitoxin - pharmacology; Doxorubicin; Doxorubicin - pharmacology; Drug Synergism; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic - drug effects; Humans; Microarrays; Molecular docking; Molecular Docking Simulation; Receptor, ErbB-2 - biosynthesis; Receptor, ErbB-2 - genetics; Receptor, ErbB-2 - metabolism; Sodium-Potassium-Exchanging ATPase - metabolism; Synergy; Transcriptome - drug effects; cur; MEFs; H2O; Microarrays; DMSO; CI; PLC; Bioelectricity; ECG; EtOH; Doxorubicin; IP3; Molecular docking; Cardiac glycosides; ROS; Vmem; Synergy; IPA; NIGMS