Aristolochic acid‐related renal cell carcinoma exhibits a distinct tumor‐immune microenvironment favoring response to immune checkpoint blockade - Lin, Po‐Hung; Chan, Jason Yongsheng; Guan, Peiyong; Hong, Jing Han; Lim, Abner Herbert; Ng, Cedric Chuan‐Young; Yeong, Joe Poh Sheng; Lee, Jing Yi; Liu, Wei; Lim, Jeffrey Chun Tatt; Pang, See‐Tong; Teh, Bin Tean (The Journal of pathology, 2024)
Keywords: Aged; Aristolochic acid; Aristolochic Acids; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Carcinoma, Renal Cell - drug therapy; Carcinoma, Renal Cell - genetics; Carcinoma, Renal Cell - immunology; Carcinoma, Renal Cell - pathology; CD8 antigen; Exome Sequencing; Female; Gene expression; Genetic analysis; Humans; immune checkpoint blockade; Immune checkpoint inhibitors; Immune Checkpoint Inhibitors - adverse effects; Immune Checkpoint Inhibitors - therapeutic use; Immunofluorescence; Immunohistochemistry; Kidney cancer; Kidney Neoplasms - drug therapy; Kidney Neoplasms - genetics; Kidney Neoplasms - immunology; Kidney Neoplasms - pathology; Male; Metastases; Metastasis; Microenvironments; Middle Aged; Mutation; mutational signature; NanoString; Renal cell carcinoma; Tumor Microenvironment - immunology; Tumors; tumor‐immune microenvironment; Vectra; Whole genome sequencing; whole‐exome sequencing; Vectra; renal cell carcinoma; NanoString; tumor‐immune microenvironment; whole‐exome sequencing; aristolochic acid; immune checkpoint blockade; mutational signature