Sequential Treatment of Metastatic Colorectal Cancer in Taiwan: Real‐World Evidence From Regorafenib and Trifluridine/Tipiracil Use

• Published in: Journal of gastroenterology and hepatology Vol. 40; no. 5; pp. 1135 - 1142
• Main Authors: Chang, Ya‐Wen, Kuo, Chun‐Nan, Chang, Chia‐Lun, Hsu, Jason C., Ko, Yu
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.05.2025
• Subjects: Aged; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Clinical outcomes; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Decision making; Drug Combinations; Female; Frontotemporal dementia; Humans; Kaplan-Meier Estimate; Liver Neoplasms - drug therapy; Liver Neoplasms - secondary; Male; Metastases; Metastasis; metastatic colorectal cancer; Middle Aged; National Health Programs; Neoplasm Metastasis; Patients; Phenylurea Compounds; Proportional Hazards Models; Pyridines - administration & dosage; Pyrrolidines - administration & dosage; real‐world study; regorafenib; Sensitivity analysis; Survival; Taiwan; Thymine; Treatment Outcome; Trifluridine; trifluridine/tipiracil; Taiwan; metastatic colorectal cancer; real‐world study; regorafenib; trifluridine/tipiracil

ABSTRACT Objective This study aims to evaluate the real‐world effectiveness and safety of sequential treatment with regorafenib and trifluridine/tipiracil (FTD‐TPI) in patients with metastatic colorectal cancer (mCRC) in Taiwan. Methods Data were obtained from Taiwan's National Health Insurance...