Impact of Acid-Reducing Agents on Sotorasib Pharmacokinetics and Potential Mitigation of the Impact by Coadministration With an Acidic Beverage

• Published in: Clinical pharmacology in drug development Vol. 14; no. 2; p. 167
• Main Authors: Cardona, Panli, Strydom, Natasha, Houk, Brett
• Format: Journal Article
• Language: English
• Published: United States 01.02.2025
• Subjects: Adult; Antacids - administration & dosage; Area Under Curve; Beverages; Cross-Over Studies; Drug Interactions; Famotidine - administration & dosage; Famotidine - pharmacokinetics; Fasting; Female; Food-Drug Interactions; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Omeprazole - administration & dosage; Omeprazole - pharmacokinetics; Omeprazole - pharmacology; Proton Pump Inhibitors - administration & dosage; Triazoles - administration & dosage; Triazoles - blood; Triazoles - pharmacokinetics; Young Adult; acid‐reducing agents; drug‐interaction; sotorasib

Sotorasib exhibits pH-dependent solubility, making it susceptible to altered exposures when coadministered with acid-reducing agents (ARAs). Several clinical studies were conducted to investigate the impact of ARAs on sotorasib pharmacokinetics under different clinically relevant scenarios and to id...