Impact of Acid-Reducing Agents on Sotorasib Pharmacokinetics and Potential Mitigation of the Impact by Coadministration With an Acidic Beverage - Cardona, Panli; Strydom, Natasha; Houk, Brett (Clinical pharmacology in drug development, 2025)
Keywords: Adult; Antacids - administration & dosage; Area Under Curve; Beverages; Cross-Over Studies; Drug Interactions; Famotidine - administration & dosage; Famotidine - pharmacokinetics; Fasting; Female; Food-Drug Interactions; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Omeprazole - administration & dosage; Omeprazole - pharmacokinetics; Omeprazole - pharmacology; Proton Pump Inhibitors - administration & dosage; Triazoles - administration & dosage; Triazoles - blood; Triazoles - pharmacokinetics; Young Adult; acid‐reducing agents; drug‐interaction; sotorasib