Atractylodes macrocephala Koidz polysaccharide ameliorates DSS-induced colitis in mice by regulating the gut microbiota and tryptophan metabolism

• Published in: British journal of pharmacology Vol. 182; no. 7; p. 1508
• Main Authors: Zhang, Qian-Wen, Yang, Meng-Jiao, Liao, Chun-Yu, Taha, Reham, Li, Qing-Yu, Abdelmotalab, Mohammed Ismail, Zhao, Si-Yu, Xu, Yan, Jiang, Zhen-Zhou, Chu, Cheng-Han, Huang, Xin, Jiao, Chun-Hua, Sun, Li-Xin
• Format: Journal Article
• Language: English
• Published: England 01.04.2025
• Subjects: Animals; Atractylodes - chemistry; Colitis - chemically induced; Colitis - drug therapy; Colitis - metabolism; Colitis - microbiology; Dextran Sulfate; Gastrointestinal Microbiome - drug effects; Male; Mice; Mice, Inbred C57BL; Polysaccharides - isolation & purification; Polysaccharides - pharmacology; Polysaccharides - therapeutic use; Receptors, Aryl Hydrocarbon - metabolism; Tryptophan - metabolism; gut microbiota‐derived tryptophan metabolites; Atractylodes macrocephala Koidz polysaccharide; pregnane X receptor; ulcerative colitis; gut microbiota

Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease, and the range of current clinical treatments is not ideal. We previously found that polysaccharide of Atractylodes macrocephala Koidz (PAMK) is beneficial in DSS-induced colitis, and we aimed to investigate the underlying mechanism...