Cold‐adapted influenza‐vectored RSV vaccine protects BALB/c mice and cotton rats from RSV challenge

• Published in: Journal of medical virology Vol. 96; no. 7; pp. e29308 - n/a
• Main Authors: Xu, Yongru, Sun, Fang, Bai, Zhifang, Bian, Chengrong, Wang, Xiliang, Zhao, Zhongpeng, Yang, Penghui
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2024
• Subjects: Administration, Intranasal; Animals; Antibodies, Viral - blood; Antibodies, Viral - immunology; Cold Temperature; cold‐adapted influenza virus; Cotton; Disease Models, Animal; Epitopes; Exo-a-sialidase; F protein; Female; fusion protein; Genetic Vectors - genetics; Genetic Vectors - immunology; Genetics; Immune response (humoral); Immune system; immunity response; Immunity, Mucosal; Immunogenicity; Influenza; Intranasal administration; Lung - immunology; Lung - pathology; Lung - virology; Lungs; Mice; Mice, Inbred BALB C; Mucosal immunity; Phenotypes; Plant viruses; Prophylaxis; Protected animals; Proteins; Rats; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - immunology; Respiratory Syncytial Virus Infections - prevention & control; Respiratory Syncytial Virus Vaccines - administration & dosage; Respiratory Syncytial Virus Vaccines - genetics; Respiratory Syncytial Virus Vaccines - immunology; Respiratory tract; Respiratory tract infection; RSV vaccine; Sensitivity analysis; Sigmodon; Sigmodontinae; Vaccine Efficacy; Vaccines; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; Viral Fusion Proteins - genetics; Viral Fusion Proteins - immunology; Viral Load; Western blotting; RSV vaccine; fusion protein; immunity response; cold‐adapted influenza virus; respiratory syncytial virus

Respiratory syncytial virus (RSV) remains the primary cause of lower respiratory tract infections, particularly in infants and the elderly. In this study, we employed reverse genetics to generate a chimeric influenza virus expressing neuraminidase‐3F protein conjugate with three repeats of the RSV F...