Efficient Synthesis and Evaluation of Novel Sulfonated Dihydropyrimidinthione Derivatives for the Treatment of UV‐B‐Induced Corneal Damage

• Published in: Photochemistry and photobiology Vol. 99; no. 4; pp. 1149 - 1156
• Main Authors: Du, Enming, Jiang, Yueping, Qin, Fangyuan, Wang, Yange, He, Siyu, Wang, Gang, Song, Zongming, Zhang, Junjie, Tao, Ye
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.07.2023
• Subjects: Anti-Inflammatory Agents - pharmacology; Apoptosis; Biocompatibility; Caspase; Cell viability; Cornea; Corneal Injuries; DNA damage; Drug development; Humans; Inflammation; Radiation damage; Signal Transduction; Ultraviolet Rays

UV‐B‐induced corneal damage remains a challenge in clinics, and it is needed to develop novel and effective medicines against UV‐B induced photodamage. 3,4‐Dihydropyrimidine‐2(1H)‐thione derivatives have shown many interesting biological activities, including antibacterial, anti‐inflammatory, antiox...