Identifying high‐risk multiple myeloma patients: A novel approach using a clonal gene signature

• Published in: International journal of cancer Vol. 155; no. 9; pp. 1684 - 1695
• Main Authors: Li, Jian‐Rong, Wang, Christiana, Cheng, Chao
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2024; Wiley Subscription Services, Inc
• Subjects: Biomarkers, Tumor - genetics; clonal gene signature; computational framework; Computer applications; Copy number; Cytogenetics; Dexamethasone; Dexamethasone - therapeutic use; DNA Copy Number Variations; Female; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; Genes; Humans; Male; Medical prognosis; Multiple myeloma; Multiple Myeloma - genetics; Prognosis; prognostic prediction; Risk groups; Transcriptome; prognostic prediction; multiple myeloma; clonal gene signature; computational framework

Multiple myeloma (MM) is a heterogeneous disease with a small subset of high‐risk patients having poor prognoses. Identifying these patients is crucial for treatment management and strategic decisions. In this study, we developed a novel computational framework to define prognostic gene signatures b...