Neurite density of the hippocampus is associated with trace eyeblink conditioning latency in 4‐ to 6‐year‐olds

• Published in: The European journal of neuroscience Vol. 59; no. 3; pp. 358 - 369
• Main Authors: Vieites, Vanessa, Ralph, Yvonne, Reeb‐Sutherland, Bethany, Dick, Anthony Steven, Mattfeld, Aaron T., Pruden, Shannon M.
• Format: Journal Article
• Language: English
• Published: France Wiley Subscription Services, Inc 01.02.2024
• Subjects: Associative learning; Blinking; Cerebellum; Cerebellum - diagnostic imaging; Child; Child, Preschool; Children; Conditioning, Classical - physiology; Conditioning, Eyelid - physiology; development; diffusion‐weighted MRI; Eyelid conditioning; Female; Hippocampus; Hippocampus - diagnostic imaging; Hippocampus - physiology; Humans; Latency; Magnetic resonance imaging; Neurites; structural MRI; Substantia alba; trace eyeblink conditioning; Unconditioned stimulus; development; structural MRI; hippocampus; trace eyeblink conditioning; diffusion-weighted MRI

Limited options exist to evaluate the development of hippocampal function in young children. Research has established that trace eyeblink conditioning (EBC) relies on a functional hippocampus. Hence, we set out to investigate whether trace EBC is linked to hippocampal structure, potentially serving...