MiR‐2110 induced by chemically synthesized cinobufagin functions as a tumor‐metastatic suppressor via targeting FGFR1 to reduce PTEN ubiquitination degradation in nasopharyngeal carcinoma

• Published in: Environmental toxicology Vol. 39; no. 6; pp. 3548 - 3562
• Main Authors: Fang, Shiyi, Peng, Lanzhu, Zhang, Mengmin, Hou, Rentao, Deng, Xing, Li, Xiaoning, Xin, Jianyang, Peng, Lingrong, Liu, Zhihua, Liu, Yiyi, Xie, Yingying, Zhou, Beixian, Fang, Weiyi, Liu, Zhen, Cheng, Chao
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.06.2024; Wiley Subscription Services, Inc
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Animals; Bioinformatics; Bufanolides - pharmacology; Cell adhesion & migration; Cell Line, Tumor; Cell migration; Cell Movement - drug effects; Degradation; Epstein-Barr virus; Female; Fibroblast growth factor receptor 1; Gene Expression Regulation, Neoplastic - drug effects; Humans; Hybridization; Lymph; Lymph nodes; Male; Medical prognosis; Metastases; Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs - genetics; MicroRNAs - metabolism; miR‐2110; Molecular modelling; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - genetics; Nasopharyngeal Carcinoma - metabolism; Nasopharyngeal Carcinoma - pathology; Nasopharyngeal Neoplasms - drug therapy; Nasopharyngeal Neoplasms - genetics; Nasopharyngeal Neoplasms - metabolism; Nasopharyngeal Neoplasms - pathology; Neoplasm Metastasis; Neoplasms; Nucleotide sequence; Phosphatase; Proteins; PTEN; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; PTEN protein; Receptor, Fibroblast Growth Factor, Type 1 - genetics; Receptor, Fibroblast Growth Factor, Type 1 - metabolism; Throat cancer; tumor metastasis; Tumors; ubiquitin; Ubiquitination; Ubiquitination - drug effects; PTEN; nasopharyngeal carcinoma; tumor metastasis; miR‐2110; ubiquitin

Tumor cell metastasis is the key cause of death in patients with nasopharyngeal carcinoma (NPC). MiR‐2110 was cloned and identified in Epstein–Barr virus (EBV)‐positive NPC, but its role is unclear in NPC. In this study, we investigated the effect of miR‐2110 on NPC metastasis and its related molecu...