NOD2 contributes to Parvimonas micra‐induced bone resorption in diabetic rats with experimental periodontitis

• Published in: Molecular oral microbiology Vol. 39; no. 6; pp. 446 - 460
• Main Authors: Chen, Ying‐Yi, Tan, Li, Su, Xiao‐Lin, Chen, Ning‐Xin, Liu, Qiong, Feng, Yun‐Zhi, Guo, Yue
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.12.2024
• Subjects: Adult; Alkaline phosphatase; Alveolar bone; Alveolar Bone Loss - metabolism; Alveolar Bone Loss - microbiology; Animal models; Animals; Bacteria; Bone composition; Bone mass; Bone resorption; Computed tomography; Deactivation; Dental Plaque - microbiology; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - microbiology; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - microbiology; Differentiation (biology); Disease Models, Animal; Female; Glucose; Gum disease; Humans; Immunohistochemistry; Inflammation; Interleukin 6; Interleukin-12 - metabolism; Interleukin-6 - metabolism; Male; Microbiomes; Microbiota; Microorganisms; Middle Aged; NOD2 protein; Nod2 Signaling Adaptor Protein - metabolism; Nucleotides; nucleotide‐binding oligomerization domain 2; Oligomerization; oral microbiome; Osteoblastogenesis; Osteoblasts; Osteoblasts - metabolism; Osteogenesis; Periodontitis; Periodontitis - metabolism; Periodontitis - microbiology; Rats; Rats, Sprague-Dawley; Relative abundance; RNA, Ribosomal, 16S; Root resorption; rRNA 16S; type 2 diabetes mellitus; X-Ray Microtomography; alveolar bone; oral microbiome; type 2 diabetes mellitus; periodontitis; nucleotide‐binding oligomerization domain 2

Background Type 2 diabetes mellitus (T2DM) may affect the oral microbial community, exacerbating periodontal inflammation; however, its pathogenic mechanisms remain unclear. As nucleotide‐binding oligomerization domain 2 (NOD2) plays a crucial role in the activation during periodontitis (PD), it is...