Functionality of natural killer cells in obese asthma phenotypes

• Published in: Clinical and experimental allergy Vol. 52; no. 12; pp. 1432 - 1439
• Main Authors: Pur Ozyigit, Leyla, Aktas, Esin Cetin, Gelmez, Yusuf Metin, Ozturk, Ayse Bilge, Gemicioglu, Bilun, Deniz, Gunnur
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.12.2022
• Subjects: Age; allergy; Asthma; Body mass index; CD107a; CD3 antigen; CD69; CD69 antigen; Cytotoxicity; early‐onset; Flow cytometry; Genotype & phenotype; Humans; Immunoregulation; Innate immunity; Interferon; Interferon-gamma; Interleukin-12 - metabolism; Interleukin-12 - pharmacology; Interleukin-17 - metabolism; Intracellular; Killer Cells, Natural - metabolism; Natural killer cells; NKG2 antigen; Obesity; Peripheral blood; phenotype; Phenotypes; Steroid hormones; phenotype; CD107a; allergy; asthma; CD69; early-onset; NK; cytotoxicity; obesity

Background Obesity‐associated asthma (OA) is a difficult to treat asthma phenotype due to its severity and poor response to inhaled steroids. Early‐onset allergic (EoOA) and late‐onset non‐allergic (LoOA) OA are suggested subtypes of this phenotype. Natural Killer (NK) cells are key elements of inna...