Anti‐skin aging effects of Gosori liquor lees extract by regulating interactions between senescent fibroblasts and adipose‐derived stem cells
When cellular ageing is accelerated by various extrinsic/endogenous stimuli, regenerative function deteriorates, and enriched secretomes, such as the senescence‐associated secretory phenotype (SASP), contribute to chronic inflammation and cause matrix degeneration. SASPs from senescent fibroblasts e...
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| Published in | International journal of cosmetic science Vol. 47; no. 3; pp. 476 - 487 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Wiley Subscription Services, Inc
01.06.2025
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| Subjects | |
| Online Access | Get full text |
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| Abstract | When cellular ageing is accelerated by various extrinsic/endogenous stimuli, regenerative function deteriorates, and enriched secretomes, such as the senescence‐associated secretory phenotype (SASP), contribute to chronic inflammation and cause matrix degeneration. SASPs from senescent fibroblasts exacerbate cellular senescence via autocrine signalling and also accelerate skin ageing through the induction of neighbouring cell senescence via paracrine signalling. The interaction between dermis fibroblasts and their neighbours, adipose‐derived stem cells (ADSCs) in the hypodermis, which lies deep in the dermis, is a potential target for skin ageing. In this study, we observed that an extract of the lees of Gosori liquor (GLE), a traditional Korean liquor made by fermenting millet and rice, suppressed the senescence of fibroblasts, including SASP production, in a replicative senescent model. We further examined whether the anti‐ageing effects of GLE on fibroblasts affected the cellular senescence of their surrounding cells, ADSCs. The results showed that senescence factors in ADSCs were suppressed by culture medium from senescent fibroblasts (SF‐CM) treated with GLE compared to the SF‐CM‐only treated group. Furthermore, the regenerative ability of ADSCs was promoted in the GLE‐treated SF‐CM group. ADSC migration was stimulated by upregulating the levels of α‐smooth muscle actin, collagen type I alpha 2, and vascular endothelial growth factor expression through the PI3K/AKT pathway. Those results indicate that GLE can exert regenerative ability by regulating fibroblasts, and adipocyte interactions, improving cellular senescence. We conducted a clinical trial of subjects over 45 years of age to confirm the anti‐ageing effects of GLE in vivo and observed changes in ageing parameters, such as skin wrinkles and volume on the face (IRB No. DM‐IRB‐2023‐809‐01‐T1). The results showed that GLE‐containing cream was more effective in improving skin wrinkles, elasticity, density, thickness, and volume around sunken eyes after 4 weeks of use than placebo. In conclusion, GLE plays an important role in inhibiting the ageing transition to ADSCs by inhibiting the senescence of fibroblasts and can be a promising anti‐ageing strategy.
Lorsque le vieillissement cellulaire est accéléré par divers stimuli extrinsèques/endogènes, la fonction régénérative se détériore et les sécrétomes enrichis, tels que le phénotype sécrétoire associé à la sénescence (senescence‐associated secretory phenotype, SASP), contribuent à l’inflammation chronique et provoquent la dégénérescence de la matrice. Les SASP des fibroblastes sénescents exacerbent la sénescence cellulaire via la signalisation autocrine et accélèrent également le vieillissement de la peau par l’induction de la sénescence des cellules voisines via la signalisation paracrine. L’interaction entre les fibroblastes du derme et leurs voisines, les cellules souches dérivées du tissu adipeux (adipose‐derived stem cells, ADSC) dans l’hypoderme, qui se trouve en profondeur dans le derme, est une cible potentielle pour le vieillissement de la peau. Dans cette étude, nous avons observé qu’un extrait de la lie de la liqueur de Gosori (Gosori liquor, GLE), un alcool coréen traditionnel fabriqué par fermentation du millet et du riz, supprimait la sénescence des fibroblastes, y compris la production de SASP, dans un modèle sénescent réplicatif. Nous avons également examiné si les effets anti‐âge du GLE sur les fibroblastes affectaient la sénescence cellulaire des cellules environnantes, les ADSC. Les résultats ont montré que les facteurs de sénescence dans les ADSC étaient supprimés par le milieu de culture des fibroblastes sénescents (SF‐CM) traité par GLE par rapport au bras traité par SF‐CM uniquement. En outre, la capacité régénérative des ADSC a été favorisée dans le bras SF‐CM traité par GLE. La migration des ADSC a été stimulée en régulant à la hausse les taux d’actine alpha du muscle lisse, de collagène de type I alpha 2 et l’expression du facteur de croissance de l’endothélium vasculaire par la voie PI3K/AKT. Ces résultats indiquent que le GLE peut exercer une capacité régénérative en régulant les fibroblastes et les interactions des adipocytes, améliorant ainsi la sénescence cellulaire. Nous avons mené un essai clinique auprès de sujets âgés de plus de 45 ans afin de confirmer les effets anti‐âge du GLE in vivo et avons observé des changements dans les paramètres de vieillissement, tels que les rides cutanées et le volume sur le visage (IRB n° DM‐IRB‐2023‐809‐01‐T1). Les résultats ont montré que la crème contenant du GLE était plus efficace que le placebo pour améliorer les rides cutanées, l’élasticité, la densité, l’épaisseur et le volume autour des yeux enfoncés après 4 semaines d’utilisation. En conclusion, le GLE joue un rôle important dans l’inhibition de la transition du vieillissement vers les ADSC en inhibant la sénescence des fibroblastes et pourrait représenter une stratégie anti‐âge prometteuse.
An extract of the lees of Gosori liquor, a traditional Korean liquor made by fermenting millet and rice, plays an important role in inhibiting the ageing transition to ADSCs by inhibiting the senescence of fibroblasts and can be a promising anti‐ageing strategy. |
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| AbstractList | When cellular ageing is accelerated by various extrinsic/endogenous stimuli, regenerative function deteriorates, and enriched secretomes, such as the senescence-associated secretory phenotype (SASP), contribute to chronic inflammation and cause matrix degeneration. SASPs from senescent fibroblasts exacerbate cellular senescence via autocrine signalling and also accelerate skin ageing through the induction of neighbouring cell senescence via paracrine signalling. The interaction between dermis fibroblasts and their neighbours, adipose-derived stem cells (ADSCs) in the hypodermis, which lies deep in the dermis, is a potential target for skin ageing. In this study, we observed that an extract of the lees of Gosori liquor (GLE), a traditional Korean liquor made by fermenting millet and rice, suppressed the senescence of fibroblasts, including SASP production, in a replicative senescent model. We further examined whether the anti-ageing effects of GLE on fibroblasts affected the cellular senescence of their surrounding cells, ADSCs. The results showed that senescence factors in ADSCs were suppressed by culture medium from senescent fibroblasts (SF-CM) treated with GLE compared to the SF-CM-only treated group. Furthermore, the regenerative ability of ADSCs was promoted in the GLE-treated SF-CM group. ADSC migration was stimulated by upregulating the levels of α-smooth muscle actin, collagen type I alpha 2, and vascular endothelial growth factor expression through the PI3K/AKT pathway. Those results indicate that GLE can exert regenerative ability by regulating fibroblasts, and adipocyte interactions, improving cellular senescence. We conducted a clinical trial of subjects over 45 years of age to confirm the anti-ageing effects of GLE in vivo and observed changes in ageing parameters, such as skin wrinkles and volume on the face (IRB No. DM-IRB-2023-809-01-T1). The results showed that GLE-containing cream was more effective in improving skin wrinkles, elasticity, density, thickness, and volume around sunken eyes after 4 weeks of use than placebo. In conclusion, GLE plays an important role in inhibiting the ageing transition to ADSCs by inhibiting the senescence of fibroblasts and can be a promising anti-ageing strategy.When cellular ageing is accelerated by various extrinsic/endogenous stimuli, regenerative function deteriorates, and enriched secretomes, such as the senescence-associated secretory phenotype (SASP), contribute to chronic inflammation and cause matrix degeneration. SASPs from senescent fibroblasts exacerbate cellular senescence via autocrine signalling and also accelerate skin ageing through the induction of neighbouring cell senescence via paracrine signalling. The interaction between dermis fibroblasts and their neighbours, adipose-derived stem cells (ADSCs) in the hypodermis, which lies deep in the dermis, is a potential target for skin ageing. In this study, we observed that an extract of the lees of Gosori liquor (GLE), a traditional Korean liquor made by fermenting millet and rice, suppressed the senescence of fibroblasts, including SASP production, in a replicative senescent model. We further examined whether the anti-ageing effects of GLE on fibroblasts affected the cellular senescence of their surrounding cells, ADSCs. The results showed that senescence factors in ADSCs were suppressed by culture medium from senescent fibroblasts (SF-CM) treated with GLE compared to the SF-CM-only treated group. Furthermore, the regenerative ability of ADSCs was promoted in the GLE-treated SF-CM group. ADSC migration was stimulated by upregulating the levels of α-smooth muscle actin, collagen type I alpha 2, and vascular endothelial growth factor expression through the PI3K/AKT pathway. Those results indicate that GLE can exert regenerative ability by regulating fibroblasts, and adipocyte interactions, improving cellular senescence. We conducted a clinical trial of subjects over 45 years of age to confirm the anti-ageing effects of GLE in vivo and observed changes in ageing parameters, such as skin wrinkles and volume on the face (IRB No. DM-IRB-2023-809-01-T1). The results showed that GLE-containing cream was more effective in improving skin wrinkles, elasticity, density, thickness, and volume around sunken eyes after 4 weeks of use than placebo. In conclusion, GLE plays an important role in inhibiting the ageing transition to ADSCs by inhibiting the senescence of fibroblasts and can be a promising anti-ageing strategy. When cellular ageing is accelerated by various extrinsic/endogenous stimuli, regenerative function deteriorates, and enriched secretomes, such as the senescence-associated secretory phenotype (SASP), contribute to chronic inflammation and cause matrix degeneration. SASPs from senescent fibroblasts exacerbate cellular senescence via autocrine signalling and also accelerate skin ageing through the induction of neighbouring cell senescence via paracrine signalling. The interaction between dermis fibroblasts and their neighbours, adipose-derived stem cells (ADSCs) in the hypodermis, which lies deep in the dermis, is a potential target for skin ageing. In this study, we observed that an extract of the lees of Gosori liquor (GLE), a traditional Korean liquor made by fermenting millet and rice, suppressed the senescence of fibroblasts, including SASP production, in a replicative senescent model. We further examined whether the anti-ageing effects of GLE on fibroblasts affected the cellular senescence of their surrounding cells, ADSCs. The results showed that senescence factors in ADSCs were suppressed by culture medium from senescent fibroblasts (SF-CM) treated with GLE compared to the SF-CM-only treated group. Furthermore, the regenerative ability of ADSCs was promoted in the GLE-treated SF-CM group. ADSC migration was stimulated by upregulating the levels of α-smooth muscle actin, collagen type I alpha 2, and vascular endothelial growth factor expression through the PI3K/AKT pathway. Those results indicate that GLE can exert regenerative ability by regulating fibroblasts, and adipocyte interactions, improving cellular senescence. We conducted a clinical trial of subjects over 45 years of age to confirm the anti-ageing effects of GLE in vivo and observed changes in ageing parameters, such as skin wrinkles and volume on the face (IRB No. DM-IRB-2023-809-01-T1). The results showed that GLE-containing cream was more effective in improving skin wrinkles, elasticity, density, thickness, and volume around sunken eyes after 4 weeks of use than placebo. In conclusion, GLE plays an important role in inhibiting the ageing transition to ADSCs by inhibiting the senescence of fibroblasts and can be a promising anti-ageing strategy. When cellular ageing is accelerated by various extrinsic/endogenous stimuli, regenerative function deteriorates, and enriched secretomes, such as the senescence‐associated secretory phenotype (SASP), contribute to chronic inflammation and cause matrix degeneration. SASPs from senescent fibroblasts exacerbate cellular senescence via autocrine signalling and also accelerate skin ageing through the induction of neighbouring cell senescence via paracrine signalling. The interaction between dermis fibroblasts and their neighbours, adipose‐derived stem cells (ADSCs) in the hypodermis, which lies deep in the dermis, is a potential target for skin ageing. In this study, we observed that an extract of the lees of Gosori liquor (GLE), a traditional Korean liquor made by fermenting millet and rice, suppressed the senescence of fibroblasts, including SASP production, in a replicative senescent model. We further examined whether the anti‐ageing effects of GLE on fibroblasts affected the cellular senescence of their surrounding cells, ADSCs. The results showed that senescence factors in ADSCs were suppressed by culture medium from senescent fibroblasts (SF‐CM) treated with GLE compared to the SF‐CM‐only treated group. Furthermore, the regenerative ability of ADSCs was promoted in the GLE‐treated SF‐CM group. ADSC migration was stimulated by upregulating the levels of α‐smooth muscle actin, collagen type I alpha 2, and vascular endothelial growth factor expression through the PI3K/AKT pathway. Those results indicate that GLE can exert regenerative ability by regulating fibroblasts, and adipocyte interactions, improving cellular senescence. We conducted a clinical trial of subjects over 45 years of age to confirm the anti‐ageing effects of GLE in vivo and observed changes in ageing parameters, such as skin wrinkles and volume on the face (IRB No. DM‐IRB‐2023‐809‐01‐T1). The results showed that GLE‐containing cream was more effective in improving skin wrinkles, elasticity, density, thickness, and volume around sunken eyes after 4 weeks of use than placebo. In conclusion, GLE plays an important role in inhibiting the ageing transition to ADSCs by inhibiting the senescence of fibroblasts and can be a promising anti‐ageing strategy. Lorsque le vieillissement cellulaire est accéléré par divers stimuli extrinsèques/endogènes, la fonction régénérative se détériore et les sécrétomes enrichis, tels que le phénotype sécrétoire associé à la sénescence (senescence‐associated secretory phenotype, SASP), contribuent à l’inflammation chronique et provoquent la dégénérescence de la matrice. Les SASP des fibroblastes sénescents exacerbent la sénescence cellulaire via la signalisation autocrine et accélèrent également le vieillissement de la peau par l’induction de la sénescence des cellules voisines via la signalisation paracrine. L’interaction entre les fibroblastes du derme et leurs voisines, les cellules souches dérivées du tissu adipeux (adipose‐derived stem cells, ADSC) dans l’hypoderme, qui se trouve en profondeur dans le derme, est une cible potentielle pour le vieillissement de la peau. Dans cette étude, nous avons observé qu’un extrait de la lie de la liqueur de Gosori (Gosori liquor, GLE), un alcool coréen traditionnel fabriqué par fermentation du millet et du riz, supprimait la sénescence des fibroblastes, y compris la production de SASP, dans un modèle sénescent réplicatif. Nous avons également examiné si les effets anti‐âge du GLE sur les fibroblastes affectaient la sénescence cellulaire des cellules environnantes, les ADSC. Les résultats ont montré que les facteurs de sénescence dans les ADSC étaient supprimés par le milieu de culture des fibroblastes sénescents (SF‐CM) traité par GLE par rapport au bras traité par SF‐CM uniquement. En outre, la capacité régénérative des ADSC a été favorisée dans le bras SF‐CM traité par GLE. La migration des ADSC a été stimulée en régulant à la hausse les taux d’actine alpha du muscle lisse, de collagène de type I alpha 2 et l’expression du facteur de croissance de l’endothélium vasculaire par la voie PI3K/AKT. Ces résultats indiquent que le GLE peut exercer une capacité régénérative en régulant les fibroblastes et les interactions des adipocytes, améliorant ainsi la sénescence cellulaire. Nous avons mené un essai clinique auprès de sujets âgés de plus de 45 ans afin de confirmer les effets anti‐âge du GLE in vivo et avons observé des changements dans les paramètres de vieillissement, tels que les rides cutanées et le volume sur le visage (IRB n° DM‐IRB‐2023‐809‐01‐T1). Les résultats ont montré que la crème contenant du GLE était plus efficace que le placebo pour améliorer les rides cutanées, l’élasticité, la densité, l’épaisseur et le volume autour des yeux enfoncés après 4 semaines d’utilisation. En conclusion, le GLE joue un rôle important dans l’inhibition de la transition du vieillissement vers les ADSC en inhibant la sénescence des fibroblastes et pourrait représenter une stratégie anti‐âge prometteuse. An extract of the lees of Gosori liquor, a traditional Korean liquor made by fermenting millet and rice, plays an important role in inhibiting the ageing transition to ADSCs by inhibiting the senescence of fibroblasts and can be a promising anti‐ageing strategy. When cellular ageing is accelerated by various extrinsic/endogenous stimuli, regenerative function deteriorates, and enriched secretomes, such as the senescence‐associated secretory phenotype (SASP), contribute to chronic inflammation and cause matrix degeneration. SASPs from senescent fibroblasts exacerbate cellular senescence via autocrine signalling and also accelerate skin ageing through the induction of neighbouring cell senescence via paracrine signalling. The interaction between dermis fibroblasts and their neighbours, adipose‐derived stem cells (ADSCs) in the hypodermis, which lies deep in the dermis, is a potential target for skin ageing. In this study, we observed that an extract of the lees of Gosori liquor (GLE), a traditional Korean liquor made by fermenting millet and rice, suppressed the senescence of fibroblasts, including SASP production, in a replicative senescent model. We further examined whether the anti‐ageing effects of GLE on fibroblasts affected the cellular senescence of their surrounding cells, ADSCs. The results showed that senescence factors in ADSCs were suppressed by culture medium from senescent fibroblasts (SF‐CM) treated with GLE compared to the SF‐CM‐only treated group. Furthermore, the regenerative ability of ADSCs was promoted in the GLE‐treated SF‐CM group. ADSC migration was stimulated by upregulating the levels of α‐smooth muscle actin, collagen type I alpha 2, and vascular endothelial growth factor expression through the PI3K/AKT pathway. Those results indicate that GLE can exert regenerative ability by regulating fibroblasts, and adipocyte interactions, improving cellular senescence. We conducted a clinical trial of subjects over 45 years of age to confirm the anti‐ageing effects of GLE in vivo and observed changes in ageing parameters, such as skin wrinkles and volume on the face (IRB No. DM‐IRB‐2023‐809‐01‐T1). The results showed that GLE‐containing cream was more effective in improving skin wrinkles, elasticity, density, thickness, and volume around sunken eyes after 4 weeks of use than placebo. In conclusion, GLE plays an important role in inhibiting the ageing transition to ADSCs by inhibiting the senescence of fibroblasts and can be a promising anti‐ageing strategy. Lorsque le vieillissement cellulaire est accéléré par divers stimuli extrinsèques/endogènes, la fonction régénérative se détériore et les sécrétomes enrichis, tels que le phénotype sécrétoire associé à la sénescence (senescence‐associated secretory phenotype, SASP), contribuent à l’inflammation chronique et provoquent la dégénérescence de la matrice. Les SASP des fibroblastes sénescents exacerbent la sénescence cellulaire via la signalisation autocrine et accélèrent également le vieillissement de la peau par l’induction de la sénescence des cellules voisines via la signalisation paracrine. L’interaction entre les fibroblastes du derme et leurs voisines, les cellules souches dérivées du tissu adipeux (adipose‐derived stem cells, ADSC) dans l’hypoderme, qui se trouve en profondeur dans le derme, est une cible potentielle pour le vieillissement de la peau. Dans cette étude, nous avons observé qu’un extrait de la lie de la liqueur de Gosori (Gosori liquor, GLE), un alcool coréen traditionnel fabriqué par fermentation du millet et du riz, supprimait la sénescence des fibroblastes, y compris la production de SASP, dans un modèle sénescent réplicatif. Nous avons également examiné si les effets anti‐âge du GLE sur les fibroblastes affectaient la sénescence cellulaire des cellules environnantes, les ADSC. Les résultats ont montré que les facteurs de sénescence dans les ADSC étaient supprimés par le milieu de culture des fibroblastes sénescents (SF‐CM) traité par GLE par rapport au bras traité par SF‐CM uniquement. En outre, la capacité régénérative des ADSC a été favorisée dans le bras SF‐CM traité par GLE. La migration des ADSC a été stimulée en régulant à la hausse les taux d’actine alpha du muscle lisse, de collagène de type I alpha 2 et l’expression du facteur de croissance de l’endothélium vasculaire par la voie PI3K/AKT. Ces résultats indiquent que le GLE peut exercer une capacité régénérative en régulant les fibroblastes et les interactions des adipocytes, améliorant ainsi la sénescence cellulaire. Nous avons mené un essai clinique auprès de sujets âgés de plus de 45 ans afin de confirmer les effets anti‐âge du GLE in vivo et avons observé des changements dans les paramètres de vieillissement, tels que les rides cutanées et le volume sur le visage (IRB n° DM‐IRB‐2023‐809‐01‐T1). Les résultats ont montré que la crème contenant du GLE était plus efficace que le placebo pour améliorer les rides cutanées, l’élasticité, la densité, l’épaisseur et le volume autour des yeux enfoncés après 4 semaines d’utilisation. En conclusion, le GLE joue un rôle important dans l’inhibition de la transition du vieillissement vers les ADSC en inhibant la sénescence des fibroblastes et pourrait représenter une stratégie anti‐âge prometteuse. When cellular ageing is accelerated by various extrinsic/endogenous stimuli, regenerative function deteriorates, and enriched secretomes, such as the senescence‐associated secretory phenotype (SASP), contribute to chronic inflammation and cause matrix degeneration. SASPs from senescent fibroblasts exacerbate cellular senescence via autocrine signalling and also accelerate skin ageing through the induction of neighbouring cell senescence via paracrine signalling. The interaction between dermis fibroblasts and their neighbours, adipose‐derived stem cells (ADSCs) in the hypodermis, which lies deep in the dermis, is a potential target for skin ageing. In this study, we observed that an extract of the lees of Gosori liquor (GLE), a traditional Korean liquor made by fermenting millet and rice, suppressed the senescence of fibroblasts, including SASP production, in a replicative senescent model. We further examined whether the anti‐ageing effects of GLE on fibroblasts affected the cellular senescence of their surrounding cells, ADSCs. The results showed that senescence factors in ADSCs were suppressed by culture medium from senescent fibroblasts (SF‐CM) treated with GLE compared to the SF‐CM‐only treated group. Furthermore, the regenerative ability of ADSCs was promoted in the GLE‐treated SF‐CM group. ADSC migration was stimulated by upregulating the levels of α‐smooth muscle actin, collagen type I alpha 2, and vascular endothelial growth factor expression through the PI3K/AKT pathway. Those results indicate that GLE can exert regenerative ability by regulating fibroblasts, and adipocyte interactions, improving cellular senescence. We conducted a clinical trial of subjects over 45 years of age to confirm the anti‐ageing effects of GLE in vivo and observed changes in ageing parameters, such as skin wrinkles and volume on the face (IRB No. DM‐IRB‐2023‐809‐01‐T1). The results showed that GLE‐containing cream was more effective in improving skin wrinkles, elasticity, density, thickness, and volume around sunken eyes after 4 weeks of use than placebo. In conclusion, GLE plays an important role in inhibiting the ageing transition to ADSCs by inhibiting the senescence of fibroblasts and can be a promising anti‐ageing strategy. |
| Author | Woo, Jieun Ji, Hyanggi Jung, Eunsun Yoon, Sohyun Park, Deokhoon Jeon, Kyungeun Kim, Hongbae Cho, Eunae Hwang, Yunhee |
| Author_xml | – sequence: 1 givenname: Jieun orcidid: 0000-0001-9277-3278 surname: Woo fullname: Woo, Jieun organization: BioSpectrum Life Science Institute, A1805, U‐TOWER, 767 – sequence: 2 givenname: Hyanggi surname: Ji fullname: Ji, Hyanggi organization: BioSpectrum Life Science Institute, A1805, U‐TOWER, 767 – sequence: 3 givenname: Kyungeun surname: Jeon fullname: Jeon, Kyungeun organization: BioSpectrum Life Science Institute, A1805, U‐TOWER, 767 – sequence: 4 givenname: Hongbae surname: Kim fullname: Kim, Hongbae organization: BioSpectrum Life Science Institute, A1805, U‐TOWER, 767 – sequence: 5 givenname: Sohyun surname: Yoon fullname: Yoon, Sohyun organization: Dermacle Inc., A1606, U‐TOWER, 767 – sequence: 6 givenname: Yunhee surname: Hwang fullname: Hwang, Yunhee organization: Dermacle Inc., A1606, U‐TOWER, 767 – sequence: 7 givenname: Eunae surname: Cho fullname: Cho, Eunae organization: BioSpectrum Life Science Institute, A1805, U‐TOWER, 767 – sequence: 8 givenname: Deokhoon surname: Park fullname: Park, Deokhoon organization: BioSpectrum Life Science Institute, A1805, U‐TOWER, 767 – sequence: 9 givenname: Eunsun orcidid: 0000-0002-5594-4645 surname: Jung fullname: Jung, Eunsun email: bioso@biospectrum.com organization: BioSpectrum Life Science Institute, A1805, U‐TOWER, 767 |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39838700$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2025 Society of Cosmetic Scientists and the Société Française de Cosmétologie. Copyright © 2025 Society of Cosmetic Scientists and the Société Française de Cosmétologie |
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| Keywords | skin‐network anti‐ageing Gosori liquor lees fibroblast ADSC paracrine senescence |
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| SubjectTerms | 1-Phosphatidylinositol 3-kinase Actin Adipocytes Adipose Tissue - cytology ADSC Aging AKT protein anti‐ageing Autocrine signalling Cell culture Cells, Cultured Cellular Senescence - drug effects Clinical trials Collagen (type I) Degeneration Dermis Endogenous stimuli Female Fermentation fibroblast Fibroblasts Fibroblasts - drug effects Gosori liquor lees Growth factors Humans Hypodermis Inflammation Liqueurs Millet Muscles paracrine senescence Paracrine signalling Phenotypes Placebos Plant Extracts - pharmacology Senescence Signal transduction Skin Skin Aging - drug effects skin‐network Smooth muscle Stem cells Stem Cells - drug effects Stimuli Vascular endothelial growth factor |
| Title | Anti‐skin aging effects of Gosori liquor lees extract by regulating interactions between senescent fibroblasts and adipose‐derived stem cells |
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