Associations between cuprotosis‐related genes and the spectrum of metabolic dysfunction‐associated fatty liver disease: An exploratory study

• Published in: Diabetes, obesity & metabolism Vol. 26; no. 12; pp. 5757 - 5775
• Main Authors: Yuan, Hai‐Yang, Liu, Wen‐Yue, Feng, Gong, Chen, Sui‐Dan, Jin, Xin‐Zhe, Chen, Li‐Li, Song, Zi‐Jun, Li, Ke, Byrne, Christopher D., Targher, Giovanni, Tian, Na, Li, Gang, Zhang, Xin‐Lei, George, Jacob, Zhou, Meng, Wang, Fudi, Zheng, Ming‐Hua
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2024; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; bulk RNA‐seq; Carcinoma, Hepatocellular - genetics; Cell activation; cuprotosis; Disease Progression; Fatty liver; Fatty Liver - genetics; Fatty Liver - metabolism; Female; Fibrosis; Genome-wide association studies; Genome-Wide Association Study; Hepatocellular carcinoma; Hepatocytes; Humans; Liver cancer; Liver Cirrhosis - genetics; Liver Cirrhosis - metabolism; Liver diseases; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Lymphocytes T; Male; metabolic dysfunction‐associated fatty liver disease; Metabolism; Middle Aged; Monocytes; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - genetics; Non-alcoholic Fatty Liver Disease - metabolism; Polymorphism, Single Nucleotide; Single-nucleotide polymorphism; sing‐cell RNA‐seq; metabolic dysfunction‐associated fatty liver disease; sing‐cell RNA‐seq; bulk RNA‐seq; genome‐wide association study; hepatocellular carcinoma; cuprotosis

Aims To explore the associations between cuprotosis‐related genes (CRGs) across different stages of liver disease in metabolic dysfunction‐associated fatty liver disease (MAFLD), including hepatocellular carcinoma (HCC). Materials and Methods We analysed several bulk RNA sequencing datasets from pat...