Network pharmacology analysis and experimental verification of the antitumor effect and molecular mechanism of isocryptomerin on HepG2 cells

• Published in: Drug development research Vol. 85; no. 2; pp. e22165 - n/a
• Main Authors: Cao, Jing‐Long, Li, Shu‐Mei, Tang, Yan‐Jun, Hou, Wen‐Shuang, Wang, An‐Qi, Li, Tian‐Zhu, Jin, Cheng‐Hao
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2024
• Subjects: AKT protein; Anticancer properties; Antitumor activity; Apoptosis; Caspase; Cell adhesion & migration; cell apoptosis; Cell cycle; Cell migration; Cell viability; Cyclin D; Cyclin-dependent kinase inhibitor p27; EGFR; Epidermal growth factor receptors; Flavonoids; G1 phase; Growth factors; Hepatocellular carcinoma; isocryptomerin; Kinases; Liver cancer; MAP kinase; Molecular modelling; Pharmacology; Reactive oxygen species; ROS; Signal transduction; Stat3 protein; Verification; isocryptomerin; cell cycle; ROS; cell apoptosis; cell migration; EGFR; hepatocellular carcinoma

Isocryptomerin (ISO) is a flavonoid isolated from the natural medicine Selaginellae Herba, which has various pharmacological activities. This study investigated the antitumor effect and underlying molecular mechanism of ISO on hepatocellular carcinoma (HCC) HepG2 cells. The cell viability assay reve...