Social Cognition in Parkinson's Disease after Focused Ultrasound Subthalamotomy: A Controlled Study

• Published in: Movement disorders Vol. 39; no. 10; pp. 1763 - 1772
• Main Authors: Guida, Pasqualina, Martínez‐Fernández, Raúl, Máñez‐Miró, Jorge U., Álamo, Marta, Foffani, Guglielmo, Fernández‐Rodríguez, Beatriz, Monje, Mariana H.G., Obeso, Ignacio, Obeso, José A., Gasca‐Salas, Carmen
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.10.2024; Wiley Subscription Services, Inc
• Subjects: Aged; Blindness; Cognition; Cognition & reasoning; Cognitive ability; Emotions - physiology; facial emotion recognition; Facial Expression; Facial Recognition - physiology; Female; FUS subthalamotomy; Humans; Male; Middle Aged; Movement disorders; Neurodegenerative diseases; Parkinson Disease - complications; Parkinson Disease - surgery; Parkinson's disease; Patients; Pattern recognition; Social Cognition; Social interactions; Theory of mind; Theory of Mind - physiology; Ultrasonic imaging; Ultrasound; facial emotion recognition; Parkinson's disease; social cognition; theory of mind; FUS subthalamotomy
• ISSN: 0885-3185; 1531-8257; 1531-8257
• DOI: 10.1002/mds.29945

Social cognition (SC) encompasses a set of cognitive functions that enable individuals to understand and respond appropriately to social interactions. Although focused ultrasound subthalamotomy (FUS‐STN) effectively treats Parkinson's disease (PD) clinical motor features, its impact and safety on cognitive‐behavioral interactions/interpersonal awareness are unknown. This study investigated the effects of unilateral FUS‐STN on facial emotion recognition (FER) and affective and cognitive theory of mind (ToM) in PD patients from a randomized sham‐controlled trial (NCT03454425). Subjects performed SC evaluation before and 4 months after the procedure while still under blind assessment conditions. The SC assessment included the Karolinska Directed Emotional Faces task for FER, the Reading the Mind in the Eyes (RME) test for affective ToM, and The Theory of Mind Picture Stories Task (ToM PST) (order, questions, and total score) for cognitive ToM. The active treatment group showed anecdotal‐to‐moderate evidence of no worsening in SC after FUS‐STN. Anecdotal evidence for an improvement was recognized in the SC score changes, from baseline to post‐treatment, for the active treatment group compared with sham for the RME, ToM PST order, ToM PST total, FER total, and recognition of fear, disgust, and anger. This study provides the first evidence that unilateral FUS‐STN does not impair social cognitive abilities, indicating that it can be considered a safe treatment approach for this domain in PD patients. Furthermore, the results suggest FUS‐STN may even lead to some improvement in social cognitive outcomes, which should be considered as a preliminary finding requiring further investigation with larger samples sizes. © 2024 International Parkinson and Movement Disorder Society.